Clinical trials: Severe Brain Trauma
Depression
Antidepressant Maintenance in Traumatic Brain Injury
The purpose of the study is to explore to what extent continuing the antidepressant medication citalopram (Celexa), after depression has responded to treatment, helps prevent the return of depressive symptoms in patients with…
- Trial name
- NCT00162916
- Testing
- citalopram
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Ontario Neurotrauma Foundation
Swallowing Disorder, Traumatic Brain Injury
Swallowing Disorders in Minimally Consciousness Patients (MCS)
This study aimed to characterize swallowing disorders in minimally consciousness patients after brain traumatic injury.
- Trial name
- TC-DEG (NCT03562104)
- Testing
- videofluoroscopy, Wessex Head Injury Matrix scale
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Rouen
Traumatic Brain Injury, Cerebral Edema
Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain Injury
The purpose of this study is to investigate the clinical improvement measured by the Glasgow Outcome Scale Extended (GOS-E) with ABX-101 compared with Placebo intramuscular injection in participants with moderate to severe TBI.
- Trial name
- NCT06096415
- Testing
- ABX-101 1mg, ABX-101 2mg
- Volunteers
- 45 people
- Sponsor
- Abalonex, LLC
OCTA, Severe Brain Injury
Effect of the Stellate Ganglion Block on the Retinal Microcirculation
Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke.
- Conditions
- OCTA, Severe Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- NCT06797752
- Testing
- OCTA Scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Tracheostomy Complication, Acquired Brain Injury
Cough Assessment in Patients With Severe Acquired Brain Injury
The cough assessment is fundamental in the weaning process as it gives information on the possibility to expel food and secretion out from the airways.
- Conditions
- Tracheostomy Complication, Acquired Brain Injury, Brain Injury, Pneumonia
- Trial name
- NCT02495558
- Testing
- Reflex Cough Test
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Brain Injuries, Spasticity, Muscle
Focal Muscular Vibration in Patients with Severe Acquired Brain Injury
Severe acquired brain injury (sABI) is a group of disorders that cause long-term disability. Rehabilitation is essential to counteract bed immobilization, muscle failure, pain, and sensory deficits that can affect the clinical…
- Trial name
- NCT05464160
- Testing
- Focal Muscular Vibration using the EVM EVO medical device (Endomedica, Italy), Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
TBI (Traumatic Brain Injury)
Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics
Children are known to have devastating impact from traumatic brain injury (TBI). The focus of treatment of severe TBI is to limit secondary insult which can aggravate brain injury and worsen outcome and is supported by monitoring…
- Trial name
- STARSHIP (NCT05688462)
- Testing
- Data Collection
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Shruti Agrawal
Deglutition Disorders
Intensive Faciltiation of Swallowing in Patients With Severe Dysphagia After Acquired Brain Injury
This study is a randomized controlled trial (RCT). Patients after severe acquired brain injury (ABI) were randomised in addition to the individual daily rehabilitation program to intensive Facial Oral Tract Therapy (F.O.T.T.®)…
- Trial name
- NCT03145740
- Testing
- Intensive F.O.T.T.®, Unspecific Stimulation of face and mouth
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intensive Care Unit
Practice of Sedation and Analgesia in Patients With Severe Brain Injury in China
Sedation and analgesia is necessary management for patients in the intensive care units. The high-level studies of sedation and analgesia in China are still deficient, especially in patients with brain injuries who even have been…
- Trial name
- NCT03975751
- Testing
- The Glasgow Coma Scale (GCS)
- Where
- China
- Volunteers
- 387 people
- Sponsor
- Capital Medical University
Injury, Brain, Traumatic, Traumatic Brain Injury
Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The investigators will conduct an observational crossover study. The investigators aim to recruit 50 participants with severe Traumatic Brain Injury (TBI) requiring intracranial pressure (ICP) monitoring during their stay at the…
- Trial name
- NCT02507973
- Testing
- Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Maryland, Baltimore
Acute Ischemic Stroke, Acute Renal Injury
Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
The aim of this trial is to assess the safety and efficacy of conestat alfa (Ruconest®, Pharming Technologies B.V.) on renal and cerebral ischemic events in patients undergoing TAVI for severe symptomatic aortic stenosis (AS)…
- Trial name
- PAIR-TAVI (NCT05145283)
- Testing
- Conestat alfa (Ruconest®), NaCl 0.9%)
- Where
- 2 sites in Switzerland
- Volunteers
- 141 people
- Sponsor
- University Hospital, Basel, Switzerland
Traumatic Brain Injury, Cerebral Palsy
Walking Dynamic Among Children With Brain Damge
The goal of the present study was to look at the effect of changing walking parameters on the dynamic walking characteristics among children post severe traumatic brain injury, children with cerebral palsy and typically developed…
- Trial name
- NCT02839369
- Testing
- walking under varies conditions
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Aquired Brain Injury
Retrospective Evaluation of Autonomic Activity Through Electrodermal Activity Measurement During Rehabilitation
Severe acquired brain injury (sABI) is a clinical condition characterised by brain damage severe enough to result in coma, with a worst Glasgow Coma Scale (GCS) score of ≤ 8 during the acute phase and a duration of more than 24…
- Trial name
- EDA-sABI (NCT07835659)
- Testing
- EmbracePlus EDA device
- Volunteers
- 72 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Traumatic Brain Injury
Study of Oxycyte in Severe Closed Head Injury
Brain damage as a result of decreased oxygen to the brain is found in 80% of patients that die with severe head injuries. Laboratory studies in animals and clinical trials have shown that increasing oxygen in the brain results in…
- Trial name
- NCT00174980
- Testing
- Oxycyte
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Tenax Therapeutics, Inc.
Respiratory Failure, Traumatic Brain Injury
A Prospective, Randomized Trial of Early Versus Late Tracheostomy in Trauma Patients With Severe Brain Injury
The purpose of this study is to evaluate the efficacy of early conversion tracheostomy from endotracheal intubation (ET) to percutaneous, dilatational tracheostomy (PDT) in traumatic brain-injured patients requiring prolonged…
- Trial name
- NCT00292097
- Testing
- Early tracheostomy, Late tracheostomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Memorial Medical Center
Severe Traumatic Brain Injury, Trauma
Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation.
Severe brain injury (SBI) is one of the world's leading causes of death and disability in young adults, but its peripheral vascular consequences in humans are poorly understood.
- Trial name
- MicroTC (NCT04597879)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble