Clinical trials: Severe Burns, active
Burn Scar
Microneedling for Burn Hypertrophic Scars
Approximately 33 to 91% of severe burn victims will develop hypertrophic scars. Hypertrophic scars are defined as erythematous (red), raised and rigid scars that can cause pain and itching, among other things.
- Trial name
- NCT05423613
- Testing
- Microneedling
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Severe Burns
Effect of Early Dexamethasone on Major Complications and All-cause Mortality in Severe Burns
Burns affect more than 11 million people worldwide each year. These injuries are responsible for severe morbidity resulting in a high societal burden and account for more than 180,000 yearly deaths especially in low- and…
- Trial name
- DEXA-BURN (NCT06968559)
- Testing
- Dexamethasone
- Where
- 10 sites in France
- Volunteers
- 478 people
- Sponsor
- Nantes University Hospital
Peer Bullying Intervention, Vodcast
Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn Patients
The purpose of this study is to evaluate the impact of an avatar-supported, teacher-student interactive, vodcast-based peer bullying prevention program-developed for adolescents-on students' ability to identify peer bullying…
- Conditions
- Peer Bullying Intervention, Vodcast, Students
- Trial name
- SIC-BURN-JAAM2 (NCT07905807)
- Testing
- Vodcast-Based Peer Bullying Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Burns
SASS 2 : Self Assembled Skin Substitute for the Autologous Treatment of Severe Burn Wounds in Acute Stage of Burn Trauma
This clinical trial is designed to assess the safety, effectiveness and benefits of Self Assembled Skin Substitute SASS grafts as a permanent skin replacement for the treatment of full-thickness burn wounds that require permanent…
- Trial name
- NCT02350205
- Testing
- Self assembled skin substitute (SASS)
- Where
- 8 sites in Canada
- Volunteers
- 52 people
- Sponsor
- CHU de Quebec-Universite Laval
Burn
Microbiota in Children With Severe Burn Injury
The research protocol consists of taking aliquots of biological specimens from skin swabs, nasopharyngeal swabs, and fecal swabs.
- Trial name
- MIBUS (NCT07098377)
- Testing
- nasopharyngeal swab for biological sample analysis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen in Major Burn Patients
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in major burn patients.
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 (NCT04534972)
- Testing
- Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Colorado, Denver
Burn Degree Second, Burn Degree Third
The Use of Cultured (Dermal) Epithelial Autografts in Severely Burned Patients
The Swisskera project is a multicenter follow-up study at the three Swiss burn centers evaluating long-term outcomes after burn wound coverage with lab-grown epithelial grafts, specifically cultured epithelial autograft (CEA)…
- Conditions
- Burn Degree Second, Burn Degree Third, Skin Transplantation, Full Thickness Skin Defects
- Trial name
- Swisskera (NCT07415577)
- Testing
- Standard of Care (SOC)
- Where
- 3 sites in Switzerland
- Volunteers
- 236 people
- Sponsor
- University Children's Hospital, Zurich
Resuscitation, Burn
Optimizing Fluid Resuscitation in Adults With Major Burns: A Randomized Trial of Burn Navigator™ Versus Parkland Formula
Burn injuries affecting ≥20% TBSA trigger major fluid shifts requiring aggressive fluid resuscitation to prevent burn shock. Traditional formulas such as the Parkland and Modified Brooke estimate initial 24-hour fluid needs, but…
- Trial name
- FLARE (NCT07307599)
- Testing
- Burn Navigator, Resuscitation (Voluven)
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Alnas Hospital
Burn, War-Related Injuries
ASV and Targeted Fluid Resuscitation in Severe Burns
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive…
- Conditions
- Burn, War-Related Injuries, Mechanical Ventilation, Infusion Fluid
- Trial name
- BURN-ASV/TFR (NCT07689097)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Sepsis, Burns
Presepsin Diagnostic Performance in Severe Burn Sepsis
This study enrolls approximately 270 adult patients with severe burns covering at least 20% of total body surface area to evaluate how well the blood biomarker presepsin diagnoses sepsis early in this high-risk population.
- Trial name
- PSEP-BURNS (NCT07060560)
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Dohern Kym
Burn Injury, Physical Injury
STAT: Standard Therapy Plus Active Therapy
The objective of the study is to assess the efficacy of STAT, an activity-based therapy protocol compared to standard therapy (ST) to improve functional outcome and reduce disability in patients recovering from burn injury.
- Conditions
- Burn Injury, Physical Injury, Thermal Burn
- Trial name
- STAT (NCT04368117)
- Testing
- Physical Therapy
- Where
- 7 sites in United States
- Volunteers
- 166 people
- Sponsor
- American Burn Association
Sepsis, Sepsis-induced Coagulopathy
Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn Patients
Sepsis is a major and life-threatening complication in patients with severe burn injuries, frequently progressing to sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC).
- Conditions
- Sepsis, Sepsis-induced Coagulopathy, Disseminated Intravascular Coagulation, Burns
- Trial name
- SIC-BURN-JAAM2 (NCT07914205)
- Testing
- Prospective calculation and kinetic monitoring of the revised Japanese Association for Acute Medicine (JAAM-2) score using biological parameters (platelet count/kinetics, PT/INR, D-dimer/FDP) measured
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Center for Traumatology and Major Burns, Ben Arous
Drug Clearance After Severe Burn Injury
Pharmacokinetic Analysis of Cefiderocol in Patients With Acute Burn Injuries
Cefiderocol is a powerful, broad spectrum antibiotic approved to treat hospital-acquired or ventilator associated pneumonia and urinary tract infections.
- Trial name
- NCT07465432
- Testing
- Cefiderocol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Tennessee
Burns, Intensive Care
Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults
This is a prospective, observational, monocentric, phase II (exploratory) cohort study aiming to describe the evolutionary profile of the initial volume of glucose distribution (IDVG) during the first four days of management of…
- Conditions
- Burns, Intensive Care, Emergencies
- Trial name
- INDICIA (NCT06469970)
- Testing
- Glucose 30% Intravenous Solution
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Severe Burn
Albumin and Prognosis of Severely Patients Burns
Hemodynamic management has long been identified as a key factor affecting burn prognosis. However, large amounts of crystalloid infusion have been associated with the development or aggravation of organ failure (acute respiratory…
- Trial name
- ALBUBURN (NCT04264065)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burns
Assessment of Safety and Effectiveness of NovoSorb® BTM in Severe Burns
This is a multi-center, pivotal study to assess the safety and effectiveness of a new method of treating severe burns using NovoSorb® Biodegradable Temporizing Matrix (BTM).
- Trial name
- NCT04090424
- Testing
- NovoSorb BTM, Standard of Care
- Where
- 26 sites in United States, India
- Volunteers
- 150 people
- Sponsor
- PolyNovo Biomaterials Pty Ltd.
Severely Burned Patients, Gut Microbiota Diversity and Composition
Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury
The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples.
- Conditions
- Severely Burned Patients, Gut Microbiota Diversity and Composition, Inflammatory Responses
- Trial name
- microbiome (NCT07329595)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Tamas Vegh, MD
Burn, Mechanical Ventilation
BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury
Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures.
- Conditions
- Burn, Mechanical Ventilation, Mechanical Ventilation Complication, ICU
- Trial name
- BURN-ASV (NCT07674563)
- Testing
- Adaptive Support Ventilation (ASV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Chemical Burns, Ocular Burns
Treatment of Severe Ocular Chemical Burns by Subconjunctival Injection of Allogeneic Mesenchymal Stem Cells: An Open-Label, Single-Arm, Multicenter Phase II Trial
Severe chemical burns of the eye are serious injuries that can cause intense inflammation of the ocular surface and destroy limbal epithelial stem cells, which are essential for corneal healing.
- Trial name
- SYMBOLCLINICAL (NCT07329569)
- Testing
- Subconjunctival injection of 1 mL with 5 million allogeneic BM-MSCs; one repeat within 21 days.
- Volunteers
- 21 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild