Clinical trials: Severe Insomnia
Colorectal Neoplasm, Circadian Rhythm Sleep Disorder
Sleep and Survival in Colorectal Cancer
Objective The objective of the current trial is to investigate the effect of perioperative sleep and circadian rhythm on the natural course of survival among patient diagnosed with colorectal cancer.
- Conditions
- Colorectal Neoplasm, Circadian Rhythm Sleep Disorder, Depression, Quality of Life
- Trial name
- NCT03254836
- Testing
- Standard of care
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Zealand University Hospital
Psychiatric Disorder, Depression
Investigating Neural Response Variability as a Single-patient Predictor of Successful CBT in Clinical Psychiatry
Many psychiatric patients are not sufficiently improved by current interventions. Functional magnetic imaging brain imaging (fMRI) has proven to be a promising method for predicting treatment outcomes in psychiatric treatment.
- Conditions
- Psychiatric Disorder, Depression, Anxiety Disorders, Insomnia
- Trial name
- TreVar (NCT04191811)
- Testing
- Internet-delivered cognitive behavioral therapy for major depressive disorder, Internet-delivered cognitive behavioral therapy for insomnia, Internet-delivered cognitive behavioral therapy for social anxiety disorder
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Major Depressive Disorder
Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder
The primary objective of the study was to determine the effects of 10-week adjunctive supplementation with 2 doses of LCn-3 fatty acids (fish oil) on cortical functional activity and biochemistry in adolescents with MDD.
- Trial name
- NCT00511810
- Testing
- Low Dose Fish Oil, High Dose Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Sleep Deprivation
Effects of Sleep Quality on Melatonin Levels and Inflammatory Response After Major Abdominal Surgery
Endogenous melatonin is produced by the pineal gland at night under normal conditions and regulates the sleep-wake cycle. Artificial light administered at night suppresses melatonin production and sleep disturbances are…
- Trial name
- NCT02824770
- Testing
- Dimming of lights and decreasing noise level, Bupivacaine (Bustesin®) via Pain Buster ® system, Tramadol HCl (Tramosel®) via PCA system (Gemstar®)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Eskisehir Osmangazi University
Anxiety Disorders, Major Depression
CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary Care
Background: Common mental illness, such as anxiety disorders and depression, is the main cause for sick leave in Sweden. Cognitive behavior therapy (CBT) has been shown to be effective in alleviating target symptoms of these…
- Conditions
- Anxiety Disorders, Major Depression, Stress Disorders, Primary Insomnia
- Trial name
- NCT01667809
- Testing
- Cognitive behavior therapy, Return to work
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Karolinska Institutet
Alzheimer Disease, Dementia
Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer's Disease
This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of THC-free cannabidiol (CBD oil) in reducing the severity of agitation among participants and 2) determine whether…
- Conditions
- Alzheimer Disease, Dementia, Major Neurocognitive Disorder With Aggressive Behavior
- Trial name
- NCT04436081
- Testing
- THC-free CBD Oil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eastern Virginia Medical School
Systolic Blood Pressure, Blood Pressure
IMST for Dementia Risk Reduction
Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and…
- Conditions
- Systolic Blood Pressure, Blood Pressure, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07349706
- Testing
- Inspiratory Muscle Strength Training High-Resistance, Inspiratory Muscle Strength Training Low-Resistance
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Florida State University
Chronic Obstructive Pulmonary Disease (COPD)
A Double-blind, Placebo-controlled, Crossover Study to Assess the Effect of Aclidinium Bromide 400 μg Bid on COPD Symptoms and Sleep Quality After 3 Weeks of Treatment in Patients With Stable Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to assess the effect of aclidinium bromide compared with placebo in improving dilatation of the airways (bronchodilation), symptoms of chronic obstructive pulmonary disease (COPD), sleep quality and…
- Trial name
- NCT02153489
- Testing
- Aclidinium bromide
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Chronic Insomnia
Efficacy and Safety of Ramelteon in Subjects With Mild to Moderate Alzheimer's Disease
The purpose of this study is to determine the efficacy of ramelteon, once daily (QD), in subjects with mild to moderate Alzheimer's Disease and sleep disturbance
- Trial name
- NCT00325728
- Testing
- Ramelteon
- Where
- 72 sites in United States
- Volunteers
- 74 people
- Sponsor
- Takeda
Major Depressive Disorder, Insomnia
A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and Insomnia
This study is a randomized, double-blind, placebo-controlled study of the safety, tolerability, and efficacy of SAGE-217 compared to placebo in adult participants with comorbid major depressive disorder (MDD) and insomnia.
- Trial name
- NCT03771664
- Testing
- SAGE-217
- Where
- 28 sites in United States
- Volunteers
- 87 people
- Sponsor
- Biogen
Moderate to Severe Insomnia
HALO Clarity™ Cranial Alternating Current Stimulation Therapy for Adults With Moderate-to-Severe Insomnia
A prospective, decentralized, individually-randomized, triple-blind* sham-controlled, superiority trial to evaluate the safety and efficacy of HALO Clarity™ device in reducing insomnia severity.
- Trial name
- NCT07659366
- Testing
- Transcranial alternating current stimulator
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Nexalin Technology
Insomnia
Group Cognitive Behavioral Therapy (CBT I) Vs. Quetiapine for Residual Insomnia Impairing Recovery Among Elderly With Stable Major Affective Disorders
The purpose of this pilot study is to assess feasibility and patient accessibility in order to design an adequately powered study to compare group cognitive behavioral therapy for insomnia (CBT-I) to quetiapine in non-demented…
- Trial name
- NCT00462618
- Testing
- Quetiapine, Cogntive behavioral therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Major Depressive Disorder, Insomnia
A Study of Eszopiclone Co-administered With Venlafaxine in Subjects With Major Depressive Disorder and Insomnia
To evaluate the antidepressant effect of adjunctive treatment with Eszopiclone in subjects receiving venlafaxine for the treatment of Major Depressive Disorder (MDD).
- Trial name
- NCT00435279
- Testing
- Eszopiclone, Venlafaxine
- Where
- 69 sites in Austria, Croatia and 8 more
- Volunteers
- 678 people
- Sponsor
- Sumitomo Pharma America, Inc.
Major Depressive Disorder With Insomnia
Efficacy of Mirtazapine in Major Depressive Disorder With Insomnia
This will be a single center, prospective, open label, quasi-experimental pre-post intervention trial in major depressive disorder (MDD) patients with insomnia. The main objectives are i.
- Trial name
- NCT05978219
- Testing
- Mirtazapine Tablets
- Where
- Bangladesh
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Dhaka
Major Depressive Disorder, Insomnia
Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon
Hypothesis I: Patients in the SSRI + ramelteon treatment group will achieve remission (defined as an IDS-C30 score of 11 or less) more quickly than those in the SSRI + placebo group.
- Trial name
- TAKEDA (NCT00642694)
- Testing
- Escitalopram, Ramelteon
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Texas Southwestern Medical Center
Elderly, Surgery
Impact of Dexmedetomidine on Sleep Quality
Sleep disturbances frequently occur in elderly patients after major surgery; and their occurrence are associated with worse outcomes including increased incidence of delirium.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03117790
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Peking University First Hospital
Major Depressive Disorder Co-Occurrent With Anxiety, Adult Patients
First choIce Antidepressants: General Practitioner's Treatment Approach in the Czech Republic
According to the local guidelines (Recommendation for General Practitioners), the first choice Anti-Depressant (AD) in Major Depressive Disorder (MDD) in primary care should be selective serotonin reuptake inhibitors (SSRI), e.g.
- Conditions
- Major Depressive Disorder Co-Occurrent With Anxiety, Adult Patients, Newly Diagnosed Depression
- Trial name
- FIAT (NCT05291897)
- Where
- 6 sites in Czechia
- Volunteers
- 28 people
- Sponsor
- Angelini Pharma Česká republika s.r.o.
Insomnia, Depression
Acupuncture for Residual Insomnia Associated With Major Depressive Disorder
The purpose of this study is to evaluate the clinical effectiveness of acupuncture treatment on residual insomnia in major depressive patients.
- Trial name
- NCT00838994
- Testing
- Acupuncture
- Where
- Hong Kong
- Volunteers
- 78 people
- Sponsor
- The University of Hong Kong
Depression
Cognitive Behavioral Therapy for the Treatment of Depression-Related Insomnia
This study will determine the effectiveness of cognitive behavioral therapy (CBT) in treating insomnia symptoms that are secondary to depression.
- Trial name
- NCT00255905
- Testing
- Cognitive behavioral therapy (CBT) for insomnia, Clinician monitoring
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Rochester
Chronic Obstructive Pulmonary Disease
Safety of Ramelteon in Subjects With Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine if ramelteon has respiratory depressant effects in subjects with moderate to severe chronic obstructive pulmonary disease.
- Trial name
- NCT00316992
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- Takeda