Clinical trials: Severe Insulin Resistance
Surgery, Postoperative Complications
Carbohydrates and Proteins 3h Before Surgery
Prolonged pre-operative fasting increases postoperative hospital stay and current evidence recommends carbohydrate (CHO) drinks 2 hours before surgery.
- Conditions
- Surgery, Postoperative Complications, Inflammation
- Trial name
- NCT01563965
- Testing
- Carbohydrate plus hydrolyzed protein beverage, Preoperative fasting of 8h
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Mato Grosso
Thyroid Associated Ophthalmopathies
The Safety and Efficacy of Sequential Hormone Therapy and IBI311 Therapy in Patients With Active Moderate to Severe TAO in the Initial Treatment.
Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause of diffuse toxic goiter…
- Trial name
- NCT07152340
- Testing
- IBI311, Glucocorticoids
- Where
- 2 sites in China
- Volunteers
- 64 people
- Sponsor
- Shanghai Changzheng Hospital
Metabolic Syndrome, Insulin Resistance
Impact of Obstructive Sleep Apnea Syndrome on Metabolic Syndrome in Severe Obesity
The aim of this project is to study the relationship between obstructive sleep apnea (OSA) and metabolic syndrome (MS) in a population of obese patients who are candidates for bariatric surgery.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Adipokines, Cytokines
- Trial name
- SYBILA (NCT01029561)
- Testing
- CPAP, Diet
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Hospital Universitari de Bellvitge
Metabolic Syndrome, Mental Disorders
Impact of Aerobic Exercise on Metabolic Syndrome, Neurocognition and Empowerment in Individuals With Mental Disorders
This study aims to develop a program of systematic physical exercise maintained for at least 12 weeks to normalize biomarkers of metabolic syndrome; improve neurocognition and social functioning; increase empowerment, self-esteem…
- Trial name
- EXERTMG (NCT02858102)
- Testing
- Physical activity program
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundación Marques de Valdecilla
Morbid Obesity, Metabolic Syndrome
The S.L.I.M.M.S. Procedure for Severe Clinical Obesity
Assessment of Gastric Bypass combined with Vertical Sleeve Gastrectomy as primary treatment for patients with severe clinical obesity.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Type2 Diabetes, Insulin Resistance
- Trial name
- SLIMMS (NCT04592601)
- Testing
- S.L.I.M.M.S. Procedure
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The N.E.W. Program
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Insulin Receptor Mutation, Partial Lipodystrophy
Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance
Background: Lipodystrophy (LD) syndromes are a group of rare disorders that affect how a person s body can store and use fat tissue. Many people with LDs become severely insulin resistant.
- Trial name
- NCT05470504
- Testing
- Pegvisomant
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Schizophrenia
Early and Short Psycho-educational Lifestyle Intervention
People with severe mental illness have an increased risk of somatic comorbidities such as metabolic syndrome, obesity, hypertension, dyslipidemia and diabetes mellitus, which induce an increased risk of early mortality, mainly…
- Trial name
- HYVIE (NCT02657941)
- Testing
- Motivational group, educational group
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hôpital le Vinatier
Psychotic Disorders
Improving Heart and Metabolic Health in People With Severe Mental Illness Through a Long-term Clinical Trial
Background Cardiometabolic conditions-including cardiovascular disease, type 2 diabetes, and obesity-are highly prevalent among individuals with psychotic disorders.
- Trial name
- LAGOM (NCT06781801)
- Testing
- Intervention
- Where
- 6 sites in Sweden
- Volunteers
- 650 people
- Sponsor
- Vastra Gotaland Region
Growth Hormone Deficiency, Cardiovascular Diseases
GH and Cardiovascular Risk Factors
Rationale: Abnormally low and high levels of insulin-like growth factor-I (IGF-I) are both associated with increased metabolic risk.
- Conditions
- Growth Hormone Deficiency, Cardiovascular Diseases, Metabolic Syndrome, Cognition
- Trial name
- NCT01877512
- Testing
- Change in daily dosage of Growth Hormone
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Amsterdam UMC, location VUmc
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Second or Third Degree Burns
Acute and Long-Term Outcome Investigations of Fenofibrate on Severely Burned Patients
The purpose of this study is to learn the following: whether long-term treatment (6 months) with fenofibrate will decrease burn related sugar and fat increased in the blood and help prevent muscle loss and improve wound healing.
- Trial name
- NCT01574131
- Testing
- Fenofibrate, Sugar Pill
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Psoriasis, Inflammation
A Proof-of-Activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors
The primary purpose of this proof-of-activity, phase 2 trial is to evaluate the safety and activity of orticumab in subjects with moderate to severe psoriasis and cardiometabolic risk factors.
- Conditions
- Psoriasis, Inflammation, Coronary Artery Disease, Cardiometabolic Syndrome
- Trial name
- NCT04776629
- Testing
- Orticumab
- Where
- 13 sites in United States
- Volunteers
- 77 people
- Sponsor
- Abcentra
Sleep Apnea, Obstructive, Metabolic Syndrome
Rehabilitation Program as an Alternative Therapy for Moderate to Severe Obstructive Sleep Apnea Syndrome
The obstructive sleep apnea/hypopnea syndrome (OSAS) is a common disease (2-4% of the general population) that generates intermittent hypoxemia and sleep fragmentation.
- Trial name
- Rehsolvas (NCT01362777)
- Testing
- In-patient rehabilitation, Educational activities alone
- Where
- France
- Volunteers
- 26 people
- Sponsor
- 5 Santé
Type 2 Diabetes, Insulin Resistance
U-500R Insulin In Type 2 Diabetes With Severe Insulin Resistance Via Omnipod
Patients with Type 2 diabetes and severe insulin resistance with very large insulin requirements who have failed all previous insulin regimens using non-concentrated forms of insulin (U100 insulin formulations) will receive 5X…
- Trial name
- NCT00606034
- Testing
- U-500 Insulin delivered by Omnipod (disposable insulin pump)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mountain Diabetes and Endocrine Center
Obesity
Exercise Training and Fitness in Severe Obesity
Obesity is commonly associated with insulin resistance and hyperinsulinemia, which seem to be linked with an impaired ability to oxidize lipids, particularly in class III obese individuals [Body Mass Index (BMI): > 40 kg*m-2].
- Trial name
- INTFMOBE (NCT02254200)
- Testing
- Fatmax group, HIIT group
- Where
- Italy
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Burns
Insulin on Post Burn Hypermetabolism
The purpose of this study is to examine the effects of insulin on helping burn patients recover faster from their burns.
- Trial name
- NCT00137254
- Testing
- Insulin, Stable Isotopes, Indocyanine Green
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- United States Army Institute of Surgical Research
Psoriasis, Metabolic Syndrome
Effect of Vitamin D Supplementation on Metabolic Parameters of Patients With Psoriasis
The purpose of this study is to determine whether supplementation with oral vitamin D (cholecalciferol) improves metabolic parameters in patients with moderate to severe psoriasis.
- Conditions
- Psoriasis, Metabolic Syndrome, Vitamin D Deficiency
- Trial name
- NCT02271971
- Testing
- Vitamin D3
- Where
- Chile
- Volunteers
- 39 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Severe Mental Disorder, Metabolic Syndrome
Evaluating the Effectiveness of the GILL eHealth Intervention to Improve Physical Health and Lifestyle Behaviours in Patients With Severe Mental Illness
The aim of this study is to evaluate the effectiveness of the nurse-led GILL (Gezondheid in Lichaam en Leefstijl) eHealth intervention in patients with serious mental illness (SMI), compared to usual care.
- Conditions
- Severe Mental Disorder, Metabolic Syndrome, Lifestyle, Somatic Screening
- Trial name
- GILL (NCT05533749)
- Testing
- GILL eHealth
- Where
- Netherlands
- Volunteers
- 258 people
- Sponsor
- Amsterdam UMC, location VUmc
Insulin Resistance, Hyperglycemia
Study of Recombinant Human Insulin-Like Growth Factor I in Patients With Severe Insulin Resistance
OBJECTIVES: I. Determine the efficacy and toxic effects of recombinant human insulin-like growth factor I (rhIGF-I) on carbohydrate tolerance, insulin action, insulin secretion, hyperandrogenism, and hyperlipidemia in patients…
- Trial name
- NCT00004419
- Testing
- insulin-like growth factor I
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Beth Israel Deaconess Medical Center