Clinical trials: Severe Mental Disorder
Major Depressive Disorder
Badalona Major Depressive Disorder Database Study
A retrospective study using a data base of anonymized medical records. The purpose of the study is to examine the different therapeutic strategies for the management of patients with major depressive disorder (MDD) and suboptimal…
- Trial name
- NCT01446692
- Where
- Spain
- Volunteers
- 2,260 people
- Sponsor
- AstraZeneca
Depression
Omacor for Perimenopausal Depression
Recently, antidepressants and other similar acting agents have been explored as a class of medications to treat major depressive disorder (MDD) in the context of perimenopause, as well as the somatic symptoms of perimenopause…
- Trial name
- NCT00517972
- Testing
- Omacor (omega-3-acid ethyl esters)
- Where
- United States
- Sponsor
- University of Arizona
Major Depressive Disorder, Insulin Resistance
Pioglitazone in Patients With Mood Disorders
The purpose of this study is to see how an insulin sensitizing medication, Pioglitazone, can cause changes in mood in some depressed patients. Study participants receive assessment of their cognitive and metabolic functioning.
- Trial name
- NCT01559857
- Testing
- Pioglitazone, Sugar Pill
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Stanford University
Major Depressive Disorder, Mobile Health
A Trial of Enhanced Versus Standard Measurement-Based Care Implementation for Depression
Measurement-based care (MBC) is an evidence-based practice that incorporates routine outcome assessment using validated rating scales to guide collaborative clinical decision-making.
- Trial name
- NCT05577494
- Testing
- Questionnaire online
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of Depression
Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can augment the effects of a single session of behavioral activation in participants with major depressive disorder.
- Trial name
- ABBA (NCT05693922)
- Testing
- Delta-beta cross-frequency transcranial alternating current stimulation via the NeuroConn DC-STIMULATOR MC, Single-session behavioral activation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia, Bipolar Disorder
A Biological Signature for the Early Differential Diagnosis of Psychosis
Schizophrenia (SZ) and mood disorders (BD, MDD) are among the most disabling disorders worldwide, with a relevant social, functional, and economic burden.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT06515522
- Testing
- differential diagnosis
- Volunteers
- 1,850 people
- Sponsor
- IRCCS San Raffaele
Major Depression, Generalized Anxiety Disorder
Study of the Changes in Metabolic Parameters in Patients Treated With Escitalopram for Six Months
The purpose of this study is to explore the changes in metabolic parameters in patients treated with escitalopram for six months for major depression, generalized anxiety disorder or panic disorder, with or without agoraphobia.
- Conditions
- Major Depression, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT00711737
- Where
- Singapore
- Volunteers
- 27 people
- Sponsor
- Changi General Hospital
Opioid Addiction
PINS Stimulator System for Deep Brain Stimulation of the Nucleus Accumbens to Treat Severe Opioid Addiction
The purpose of this study is to verify efficacy and safety of a bilateral deep brain stimulation (DBS) of the Nucleus accumbens (NAc) as a treatment option for severe opioid addiction.
- Trial name
- NCT02282072
- Testing
- Deep brain stimulation：PINS Stimulation System
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Major Depressive Disorder
Riluzole Augmentation Pilot in Depression (RAPID) Trial
The investigators are doing a research study to find out if riluzole, when taken along with a standard antidepressant (sertraline) can help people with major depression.
- Trial name
- RAPID (NCT01703039)
- Testing
- Riluzole, Sertraline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Major Depressive Disorder
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
Primary Objective: To compare the efficacy and safety of DVS-233 SR versus placebo treatment in reducing the relapse rate of depressive symptoms in subjects with major depressive disorder (MDD), and to compare the percentages of…
- Trial name
- NCT00075257
- Testing
- DVS-233 SR
- Volunteers
- 603 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Schizophrenia, HIV Infections
The Quality of Life of Patients With Severe Illnesses
Lately researchers and clinicians have emphasized the health related quality of life. Several reasons account for this trend. First of all, the advanced medical practices have contributed to the increased life expectancy.
- Trial name
- NCT00173329
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Major Depressive Disorder
Neuroimaging Study of Bupropion Treatment in Patients With Major Depressive Disorder
The current study is being conducted in patients with major depression. The study aims to 1) investigate the combined effects of selective serotonin reuptake inhibitor (SSRI) and bupropion compared to SSRI alone on the…
- Trial name
- NCT01541475
- Testing
- Bupropion, Escitalopram, Escitalopram
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ewha Womans University
Bipolar Disorder, Major Depressive Disorder
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide
- Trial name
- NCT05317481
- Testing
- BE-SMART-DR, psychoeducational control comparator condition (CC)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Major Depression, Dysthymia
Are Two Antidepressants a Good Initial Treatment for Depression?
Relatively drug naive patients will receive two antidepressant medications as initial treatment.
- Conditions
- Major Depression, Dysthymia, Depression NOS
- Trial name
- NCT00296712
- Testing
- escitalopram + bupropion
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Severe Mental Illness, Severe Mental Disorder
Outcome of Patients With Severe Mental Illness in the Intensive Care Unit
Severe mental illnesses (SMIs), such as major depression, schizophrenia, and bipolar disorder, carry a significant prevalence among patients admitted to the intensive care unit (ICU), estimated at an average of 19%.
- Trial name
- REPSYRE (NCT07705802)
- Testing
- Observational follow-up
- Where
- 30 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Major Depressive Disorder
Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder
This study will examine whether semaglutide may improve cognitive function in individuals with major depressive disorder (MDD).
- Trial name
- NCT04466345
- Testing
- Semaglutide
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University Health Network, Toronto
Depression
Effectiveness of Culturally Based Congruent Care in Treating Hispanics With Major Depressive Disorder
This study will develop and evaluate the effectiveness of a culturally based program that aims to facilitate entry, retention, and successful treatment in specialized mental health services for Hispanics with major depressive…
- Trial name
- NCT00247195
- Testing
- Culturally Congruent Assessment and Treatment
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer's Disease, Dementia
Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients
The primary aim is to determine whether Divalproex ER or one of the atypical antipsychotics is more effective improving dementia related behavioral symptoms in patients with dementia, and evaluate the impact of such improvements…
- Conditions
- Alzheimer's Disease, Dementia, Behavioral Symptoms
- Trial name
- NCT00375557
- Testing
- Divalproex ER, Quetiapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Major Depressive Disorder (MDD)
Efficacy and Safety of Transcranial Temporal Interference Stimulation for Depression
The goal of this clinical trial is to learn whether transcranial temporal interference stimulation (tTIS) can help treat major depressive disorder (MDD) in adults.
- Trial name
- NCT07612501
- Testing
- Active Transcranial Temporal Interference Stimulation Targeting Left ALIC, Active Transcranial Temporal Interference Stimulation Targeting Left sgACC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yonggui Yuan
Bipolar Disorder, Major Depression
Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness
The overall aim of this program of research is to improve the continuity of care for patients with serious mental illness (SMI) by supporting a safer and more efficient bridge from hospital to outpatient care using a mobile…
- Conditions
- Bipolar Disorder, Major Depression, Schizophrenia
- Trial name
- tFOCUS (NCT05703412)
- Testing
- Transition-FOCUS mHealth Intervention, Check-In
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Butler Hospital