Clinical trials: Severe Mental Disorders
Dementia, Dysphagia
Family Caregiver Online Survey (Dementia and Swallowing Difficulties)
The Family Caregiver Survey is a one-time, 30-minute, online survey for people living with and caring for a family member with dementia.
- Conditions
- Dementia, Dysphagia, Dementia Alzheimers, Dementia, Vascular
- Trial name
- NCT06471660
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Tourette Syndrome, Deep Brain Stimulation
Deep Brain Stimulation in Tourette Syndrome
Op-TICS is a clinical investigation of the use of Deep Brain Stimulation (DBS), with a CE marked implantable device, to reduce severe motor and vocal tics in patients who suffer from Tourette Syndrome (TS).
- Trial name
- Op-TICS (NCT06388291)
- Testing
- Deep Brain Stimulation
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University College, London
Dementia
Compassion Pilot Intervention Study to Enhanced Integrated Care for People With Severe Memory Problems
The investigators developed the theory-driven 'Compassion Intervention', an integrated, interdisciplinary approach to address existing gaps in end-of-life care for people with advanced dementia.
- Trial name
- NCT02840318
- Testing
- Compassion Intervention
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- University College, London
Insomnia
Group Cognitive Behavioral Therapy (CBT I) Vs. Quetiapine for Residual Insomnia Impairing Recovery Among Elderly With Stable Major Affective Disorders
The purpose of this pilot study is to assess feasibility and patient accessibility in order to design an adequately powered study to compare group cognitive behavioral therapy for insomnia (CBT-I) to quetiapine in non-demented…
- Trial name
- NCT00462618
- Testing
- Quetiapine, Cogntive behavioral therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Major Depressive Disorder
Improving Therapeutic Learning in Depression: Proof of Concept
Despite advances in both pharmacotherapy and psychotherapy for major depression, non-response and partial-response remain relatively common outcomes, motivating the search for new treatments.
- Trial name
- NCT02376257
- Testing
- 250 mg DCS, 100 mg Modafinil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Boston University Charles River Campus
Major Depression
Assessment of Hedonic and Motivational States in Major Depression ( MOODDIS)
Major depression is a frequent psychiatric disorder with an estimated lifetime prevalence of 16-17% in the general population. Although its pathophysiology is not completely understood, a large body of literature pleads for a…
- Trial name
- MOODDIS (NCT03060967)
- Testing
- Computer-based tasks
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Depression
Comparison of Two Psychotherapy Treatments for Depressed Women With a History of Sexual Abuse
This study will compare the effectiveness of individual versus interpersonal psychotherapy in treating depressed women with a history of sexual abuse.
- Trial name
- NCT00257400
- Testing
- Interpersonal Psychotherapy (IPT), Individual Psychotherapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Rochester
Major Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) in the Treatment of Major Depressive Disorder
The primary purpose of this study is to compare the antidepressant efficacy and safety of two doses of DVS SR (25 and 50 mg/day) in the treatment of adults with Major Depressive Disorder.
- Trial name
- NCT00798707
- Testing
- Desvenlafaxine Succinate Sustained-Release (DVS SR)
- Where
- 78 sites in United States, Japan
- Volunteers
- 709 people
- Sponsor
- Pfizer
Bipolar II Disorder, Major Depressive Episode
Open-Label Study of Geodon in Non-Rapid Cycling Bipolar II Patients With Major Depression
The purpose of this study is to evaluate the antidepressant effectiveness of Geodon for the treatment of patients diagnosed with Bipolar II disorder who are currently experiencing a major depressive episode.
- Trial name
- NCT00237666
- Testing
- Ziprasidone
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Medical Research Network
Depression, Major Depressive Disorder
Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression
Researchers hope to see if the data smartphones collect continuously can be used to predict if patient's depression symptoms will return.
- Trial name
- NCT07174557
- Testing
- MoodTriggers Application
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Major Depressive Disorder
Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
There is strong evidence that patients with major depressive disorder (MDD) have an increased risk of developing coronary heart disease (CHD).
- Trial name
- MDD (NCT01568307)
- Testing
- Participants will be prescribed an approved selective serotonin re-uptake inhibitor (SSRI) antidepressant.
- Where
- 4 sites in Australia
- Volunteers
- 80 people
- Sponsor
- Baker Heart and Diabetes Institute
Erectile Dysfunction
Low-intensity Shockwaves Therapy + Tadalafil 5mg for the Treatment of Severe Erectile Dysfunction
This is a randomized, double-blind, sham-controlled, 3 parallel arms, clinical trial. All patients will be PDE5I users or ex-users.
- Trial name
- NCT03642366
- Testing
- Dornier Aries2 LiST Device + 5mg Tadalafil (1), Dornier Aries2 LiST Device + 5mg Tadalafil (2)
- Where
- Greece
- Volunteers
- 51 people
- Sponsor
- Institute for the Study of Urological Diseases, Greece
Major Depressive Disorder
Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder
Double-Blind, Placebo-Controlled, Multicenter Study of Efficacy and Safety
- Trial name
- NCT02129751
- Testing
- bupropion hydrobromide
- Volunteers
- 246 people
- Sponsor
- Bausch Health Americas, Inc.
Mental Health, Oral Health Care
The Mouth Matters in Mental Health Trial -2
This clinical trial will evaluate the effectiveness and cost-effectiveness of a link work intervention for supporting people with severe mental health difficulties to attend a routine dental appointment.
- Conditions
- Mental Health, Oral Health Care, Psychosis
- Trial name
- NCT07470437
- Testing
- Link work intervention
- Where
- 5 sites in United Kingdom
- Volunteers
- 480 people
- Sponsor
- Lancashire and South Cumbria NHS Foundation Trust
Alzheimer's Disease
A 36-Week Safety Extension Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
To evaluate the safety and tolerability of ELND005 treatment with up to 36 weeks exposure, in Moderate to Severe AD patients with agitation and aggression.
- Trial name
- NCT01766336
- Testing
- Group 1 ELND005, Group 2 ELND005
- Where
- 46 sites in United States, Canada and 2 more
- Volunteers
- 296 people
- Sponsor
- OPKO Health, Inc.
Severe Mental Illness, Nicotine Dependence
Electronic Decision Support Systems for Smokers With Severe Mental Illness
This randomized clinical trial among SMI smokers assessed whether the EDSS with carbon monoxide monitor and health-checklist feedback lead to higher rates of initiation of smoking cessation treatment, days of smoking abstinence…
- Conditions
- Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
- Trial name
- NCT01412866
- Testing
- EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alzheimer's Type Dementia
A Study Versus E2020 10mg Followed by an Open-label Extension Phase to Explore the Safety of E2020 SR 23 mg in Japanese Subjects With Severe Alzheimer's Type Dementia
The purpose of this study is to compare 23 mg donepezil sustained release (SR) to the currently marketed formulation of 10 mg donepezil immediate release (IR) in patients with severe Alzheimer's disease.
- Trial name
- NCT01276353
- Testing
- E2020
- Where
- 11 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Eisai Inc.
Treatment Resistant Depression
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic…
- Trial name
- TRANSCEND (NCT06423430)
- Testing
- Active-stimulation
- Where
- 26 sites in United States
- Volunteers
- 100 people
- Sponsor
- Abbott Medical Devices
Depressive Disorder
Omega-3 Fatty Acids for Major Depressive Disorder During Pregnancy
Whether high-dose omega-3 fatty acids supplement would be an effective treatment in patients with major depressive disorder during pregnancy and breast-feeding.
- Trial name
- NCT00618865
- Testing
- Omega-3 fatty acids
- Volunteers
- 36 people
- Sponsor
- National Science and Technology Council, Taiwan
Emotional Disturbances, Behavior Disorders
The Safety-Net Approach
The Safety-Net project, is intended to disrupt disparities in mental health treatment access for children at-risk for childhood trauma (ACEs) and/or serious emotional disturbance (SED).
- Conditions
- Emotional Disturbances, Behavior Disorders, Mental Disorders, Severe
- Trial name
- Safety-Net (NCT04675567)
- Testing
- Safety-Net Care Team Model
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Cambridge Health Alliance
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