Clinical trials: Severe Mental Disorders
Severe Mental Illness
Use of AI Chatbots for Mental Health
The goal of this observational study is to learn how patients with mental disorders use, perceive, and evaluate generative artificial intelligence (AI) chatbots for mental health-related purposes.
- Trial name
- NUKI-PSY (NCT07658547)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Nicotine Dependence, Major Depressive Disorder
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers
Persons who struggle with depression smoke at high rates and experience low quit rates in treatment. The best way to improve cessation treatment for this underserved population remains unknown.
- Trial name
- NCT02378714
- Testing
- Varenicline, BASC, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Northwestern University
Disorder, Major Depressive
Smartphone-enabled Health Coaching Intervention for Youth Diagnosed With Major Depressive Disorders
Randomized controlled trial (RCT) comparing youth diagnosed with major depressive disorder treated with online mindfulness-based cognitive behavioural therapy vs. standard psychiatric care (as wait-list controls).
- Trial name
- NCT03406052
- Testing
- Smartphone-Assisted MB-CBT
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- York University
Depression, Opioid-use Disorder
Ketamine for the Treatment of Opioid Use Disorder and Depression
The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for concurrent opioid addiction and depression when used in conjunction with buprenorphine…
- Conditions
- Depression, Opioid-use Disorder, Opioid Abuse
- Trial name
- NCT04177706
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
HIV, AIDS
HIV/AIDS, Severe Mental Illness and Homelessness
This is a two-arm randomized controlled trial (RCT) for 308 seriously mentally ill adults (SMI) engaging in risky sexual and/or drug use behavior, comparing a brief HIV primary and secondary prevention intervention [Skills…
- Trial name
- NCT01172704
- Testing
- Skills Building - Motivational Interviewing
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Depressive Disorder, Major
Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA
Prospective observational cohort study to determine cost-effectiveness of ECT compared to medication in the treatment of major depressive disorder (MDD) in the Netherlands.
- Trial name
- PROSPECT (NCT05306184)
- Testing
- Electroconvulsive therapy (ECT)
- Where
- 2 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Radboud University Medical Center
Depression
Safety and Efficacy of EVT 101 in Treatment-Resistant Depression
This study is a 4-week, randomized, double-blind, parallel-group, placebo-controlled monotherapy study in patients with treatment-resistant major depression.
- Trial name
- NCT01128452
- Testing
- EVT 101
- Where
- 14 sites in United States
- Volunteers
- 8 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder
tVNS Effects on Motivation in Depression
Attaining goals or rewards commonly entails response costs. In light of cost and benefits, how do participants decide what effort should be put in to give it a shot? Figuratively, you may "go with your gut", but the literal…
- Trial name
- NCT05120336
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
D-cycloserine for Major Depressive Disorder
For many depression patients treatment changes are required, including switching to another antidepressant and addition of a second antidepressant or a non-antidepressant agent ("augmentation").
- Trial name
- NCT00408031
- Testing
- D-cycloserine
- Where
- 2 sites in Israel
- Volunteers
- 26 people
- Sponsor
- Herzog Hospital
Depression, Major Depressive Disorder
The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression
Many people with depression are treated with a serotonin-specific reuptake inhibitor anti-depressant (SSRI) and feel 'better'. Although many people feel 'better', they do not feel completely 'well'.
- Conditions
- Depression, Major Depressive Disorder, Unipolar Depression
- Trial name
- NCT00125957
- Testing
- Wellbutrin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mclean Hospital
Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder
Symptoms and Mechanisms of Child Psychiatric Disorders
In this study the investigators will examine psychiatric symptoms, central neurocognitive functions, parental stress and attachment styles, and biological factors that can give new knowledge about some of the mechanisms present…
- Conditions
- Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder, Severe Irritability
- Trial name
- NCT05049356
- Where
- 2 sites in Norway
- Volunteers
- 218 people
- Sponsor
- Oslo University Hospital
Major Depressive Disorder
Intradermal Acupuncture as an Adjunct to SSRI Tapering in Major Depressive Disorder
This randomized controlled trial aims to evaluate the clinical efficacy of intradermal acupuncture as an adjunctive intervention to assist selective serotonin reuptake inhibitor (SSRI) dose reduction or discontinuation in adult…
- Trial name
- NCT07390981
- Testing
- Selective Serotonin Reuptake Inhibitors (SSRIs), Intradermal Acupuncture
- Volunteers
- 114 people
- Sponsor
- First People's Hospital of Hangzhou
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Major Depressive Disorder
Pharmacogenomic Testing in Major Depressive Disorder
This is a two-arm double-blind prospective randomized controlled trial (RCT) to evaluate clinical impact of pharmacogenomic testing on the treatment of major depressive disorder.
- Trial name
- NCT03228953
- Testing
- Pharmacogenomic testing
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Columbia University
Acute Disseminated Encephalomyelitis, Devic's Syndrome
Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone
OBJECTIVES: I. Evaluate the effectiveness of plasma exchange in the treatment of acute severe attacks of inflammatory demyelinating disease in patients who have failed intravenous steroid therapy.
- Conditions
- Acute Disseminated Encephalomyelitis, Devic's Syndrome, Marburg's Variant of Multiple Sclerosis, Balo's Concentric Sclerosis
- Trial name
- NCT00004645
- Testing
- Plasma exchange
- Volunteers
- 22 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Major Depressive Disorder, Depression
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder
The purpose of this study is to determine if TC-5214 or placebo (a tablet that looks like medicine tablet or capsule, but contains no active medicine) is safe and effective when taken together with another antidepressant.
- Trial name
- NCT01180400
- Testing
- TC-5214
- Where
- 66 sites in Czechia, Estonia and 8 more
- Volunteers
- 295 people
- Sponsor
- AstraZeneca
Major Depressive Disorder, Sleep Disturbance
A Transdiagnostic Sleep and Circadian Treatment for Major Depressive Disorder
This study will examine the use of a transdiagnostic Sleep and Circadian Treatment (TranS-C) in treating Major Depressive Disorder (MDD) in Chinese adults.
- Trial name
- NCT03786731
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Major Depressive Disorder
Individual MBCT vs. CBT in Major Depression: A Pilot Study.
Background: Depression is a highly recurrent disorder, which often requires lifelong treatment. Psychotherapy has an important role in the treatment of depression, both in the treatment of the acute phase and in prevention of…
- Trial name
- NCT05108701
- Testing
- Individual Psychotherapy
- Volunteers
- 27 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Severe Postpartum Depression
A Study of BRII-296 in Adults With Severe Postpartum Depression (PPD)
The primary purpose of this study is to evaluate the safety and tolerability of BRII-296 administered by 2 intramuscular injections, administered with Depo Medrol as assessed by the incidence of adverse events, changes from…
- Trial name
- NCT06057012
- Testing
- BRII-296, Depo Medrol
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brii Biosciences Limited
Major Depressive Disorder
Exercise-priming of CBT for Depression: the CBT+ Trial
This study investigates the effects of intentionally sequencing aerobic exercise immediately prior to cognitive behavioral therapy (CBT) to determine its effects on mechanisms of CBT (i.e., working alliance, behavioral…
- Trial name
- NCT07221929
- Testing
- Rest, Aerobic Activity
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
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