Clinical trials: Severe Obesity
Bariatric Surgery
Energy Expenditure Pre and Post Bariatric Surgery
Obese patients are going to be submitted to indirect calorimetry pre-operatively and we are going to repeat the same exam 6 months after bariatric surgery (post Roux-en-Y gastric Bypass surgery).
- Trial name
- NCT01231087
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Gastrocirurgia, Brazil
Morbid Obesity, Obesity
Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients
Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse.
- Conditions
- Morbid Obesity, Obesity, Respiratory Failure, Atelectasis
- Trial name
- NCT07542093
- Volunteers
- 45 people
- Sponsor
- Assiut University
Obesity
Metabolomic Fingerprint After Bariatric Surgery
Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity.
- Trial name
- NCT02480322
- Testing
- bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- eSwiss Medical & Surgical Center
Bariatric Surgery Candidate, Cholelithiases
Multicenter Cohort of 768 High-risk Patients With Symptomatic Gallstones, Adding Cholecystectomy Did Not Increase Length of Stay or Perioperative Morbidity, Supporting it as a Safe Single-stage Option
Despite numerous single-center reports and meta-analyses, few studies have directly compared outcomes of LSG with versus without concomitant cholecystectomy exclusively in a high-risk cohort as defined above.
- Trial name
- NCT07772440
- Volunteers
- 2,512 people
- Sponsor
- Zagazig University
Morbid Obesity
Pharmacokinetics of Acetaminophen in Morbidly Obese Patients
This study will investigate the pharmacokinetics of acetaminophen in morbidly obese patients versus normal weight patients. Specifically the different metabolic pathways of acetaminophen in morbidly obese adults will be…
- Trial name
- APAP (NCT01764555)
- Testing
- acetaminophen 2 g
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Severe Obesity Design as BMI > 35kg/m2
Preoxygenation Optimisation in Obese Patients
Oro-tracheal intubation in operating room in obese patients with BMI > 35kg/m2 remains a critical event. The aim of this study is to determine whether Nasal High Flow Therapy by nasal cannula Optiflow® is more efficient than the…
- Trial name
- PREOPTI-POOP (NCT03106441)
- Testing
- High flow oxygen therapy by nasal cannula. Optiflow®, Facial mask oxygenation in BIPAP ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Surgery, Obesity
A Randomized Controlled Study Evaluating Bariatric Surgery as a Treatment for Severe NASH With Advanced Liver Fibrosis in Non-severe Obese Patients
The aim of the study is to demonstrate the superiority of bariatric surgery on the disappearance of NASH without worsening of fibrosis in comparison to medical standard treatment in obese patients (35 kg/m² > BMI ≥ 30 kg/m²) with…
- Conditions
- Surgery, Obesity, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
- Trial name
- NASHSURG (NCT03472157)
- Testing
- Lifestyle therapy, Bariatric surgery
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Obesity, Morbid Obesity
Ultrasound-Guided Axillary Brachial Plexus Block: Influence of Obesity
Axillary brachial plexus block (freezing the nerves in armpit) is commonly performed as a primary anesthetic technique for the elbow/ forearm or hand surgery.
- Trial name
- NCT02033265
- Testing
- Brachial plexus block
- Where
- Canada
- Volunteers
- 249 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Morbid Obesity
Effect of Oxalidine Combined with Reduced-opioid Anesthesia on Multimodal Analgesia in Morbidly Obese Patients Undergoing Bariatric Surgery
The goal of this study is to elucidate the efficacy and safety of oxelidine combined with oligopiate anesthesia for multi-modal analgesia in weight-loss surgery in morbidly obese patients, and to discover a new strategy for…
- Trial name
- NCT06712199
- Testing
- oxalidine
- Where
- China
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Yongtao Sun
Bariatric Surgery Candidate, Obesity, Morbid
Korean OBEsity Surgical Treatment Study
This trial is a multi-center, single-arm, prospective, observational cohort study of patients undergoing primary bariatric surgical procedures in Korea.
- Trial name
- KOBESS (NCT03100292)
- Testing
- Sleeve gastrectomy or Roux-en-Y gastric bypass
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Preeclampsia With Severe Features
Acute Labetalol Use in Preeclampsia
The purpose of this study is to understand if administration of a personalized dose of the anti-hypertensive medication, labetalol, based on patient's body-mass index, will be more effective at controlling severe hypertension…
- Trial name
- ALERT (NCT03872336)
- Testing
- Experimental labetalol dose, Current standard of care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Albany Medical College
Obesity, Morbid, Bariatric Surgery Candidate
Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery
Morbid obesity leads to non-alcoholic fatty liver disease (NAFLD), and not all NAFLD cases benefit from weight loss e.g. after bariatric surgery.
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, NAFLD, Microbiome
- Trial name
- NCT03391401
- Testing
- Bariatric surgery
- Where
- 2 sites in Germany
- Volunteers
- 204 people
- Sponsor
- St. Franziskus Hospital
Lumbar Spinal Stenosis, Lumbar Degenerative Disease
Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery
Obesity is prevalent among patients with lumbar degenerative disease and is a known risk factor for perioperative complications in spinal surgery.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Degenerative Disease, Obesity, Intraabdominal Hypertension
- Trial name
- OBESPINE (NCT07688265)
- Testing
- Intraabdominal Pressure Measurement via Urinary Bladder Catheter, Total Intravenous Anesthesia (TIVA)
- Volunteers
- 90 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Obesity, Morbid
Impact of Size of Gastric Sleeve on the Weight Loss. Correlation With Gastric Function and Endocrine-metabolic Changes.
Morbid Obesity (MO) is considered the most important epidemic in the developed world in the twenty-first century. After initial assessment of morbidly obese patients and the exclusion of potentially correctable causes, management…
- Trial name
- NCT02144545
- Testing
- Bougie Size 33 Fr, Bougie Size 42 Fr, Distance pylorus 2 cm
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Bariatric Surgery, Obesity
Ovarian Reserve and Bariatric Surgery
The expansion of the obesity epidemic is accompanied with an increase in bariatric procedures, in particular in women of reproductive age.
- Conditions
- Bariatric Surgery, Obesity, Reproductive Health, Fertility
- Trial name
- BARIAOVO (NCT04583150)
- Testing
- Bariatric surgery
- Where
- 14 sites in France
- Volunteers
- 238 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Obesity
Garcinia Mangostana Extracts in the Management of Weight Loss
Obesity is one of the greatest public health challenges of the 21st century. Its prevalence has tripled in many countries of the European Region since the 1980s, and the numbers of those affected continue to rise at an alarming…
- Trial name
- NCT02823561
- Testing
- Garcinia mangostana, Control group
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Influenza, Obesity
Effectiveness and Tolerability of Influenza Vaccine in Patients at Risk for Severe and Complicated Influenza
The aim of the study is to evaluate simultaneously the immunological and clinical efficacy and tolerability of an influenza vaccine, inactivated, quadrivalent, with cleaved virus, in patients at risk for severe and complicated…
- Conditions
- Influenza, Obesity, Pregnancy; Infection, Elderly Infection
- Trial name
- NCT06286488
- Testing
- Vaxigrip
- Where
- Poland
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Obesity, Morbid, Drug Use
Evaluation of the Implementation of Drug Prescription Recommendations Using Clinical Decision Support in Patients With Severe Obesity: Retrospective Study
No drug prescription guidelines for severe obesity (BMI>35 kg/m2) are available, leading to non-standardized and / or potentially inappropriate drug management.
- Trial name
- RECOB-MED (NCT06517303)
- Where
- 2 sites in France
- Volunteers
- 1,050 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Surgery
Gastric Bypass, Gastric Band or Sleeve Gastrectomy to Treat Obesity
Obesity is an increasing health problem in the United Kingdom (UK) and is predicted to worsen. In the UK and worldwide the three most commonly performed operations are laparoscopic adjustable gastric banding ('BAND surgery')…
- Conditions
- Obesity, Surgery, Quality of Life, Weight Loss
- Trial name
- ByBandSleeve (NCT02841527)
- Testing
- Gastric Band, Gastric Bypass, Sleeve Gastrectomy
- Where
- 12 sites in United Kingdom
- Volunteers
- 1,351 people
- Sponsor
- University of Bristol
Morbid Obesity
Sleeve Gastrectomy Outcomes With Different Stapling Devices
Sleeve gastrectomy is now the most commonly performed bariatric surgery. While many studies have evaluated factors that may minimize post-operative hemorrhage and staple-line leak, the investigators are unaware of any studies…
- Trial name
- NCT02731079
- Testing
- Covidien iDrive, Ethicon Echilon
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Edna Rath