Clinical trials: Severe Obesity
Sleep Apnea, Obstructive
A Study of IBI362 in Chinese Subjects With Obstructive Sleep Apnea and BMI≥28 kg/m2
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study to evaluate the efficacy and safety of IBI362 in subjects with moderate-to-severe obstructive sleep apnea (OSA) and a body mass index…
- Conditions
- Sleep Apnea, Obstructive, Obesity
- Trial name
- NCT06931028
- Testing
- IBI362
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Obesity
Deep Transcranial Magnetic Stimulation (TMS) With Paired Associative Stimulation (PAS) for the Treatment of Food Addiction in Obesity
The neurobiological underpinnings of obesity point to brain asymmetry in cortical and deeper brain regions. Furthermore, chemical, structural and functional imbalance in cortical and sub-cortical brain regions alters reward…
- Trial name
- FAOB (NCT02761369)
- Testing
- A multi-channel deep TMS device with an H-coil (Brainsway Ltd)
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Morbid Obesity
Lifestyle vs.Surgery for Morbid Obesity Treatment
The purpose of the current study is to determine whether an intensive lifestyle intervention was as effective as surgery to treat morbid obesity nine years post-intervention.
- Trial name
- NCT02122029
- Testing
- Lifestyle counselling, Bariatric Surgery
- Where
- Greece
- Volunteers
- 29 people
- Sponsor
- Harokopio University
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-NPAP)
The objective of this clinical trial is to evaluate the efficacy of investigational drug UBT251 in the treatment of moderate-to-severe obstructive sleep apnea (OSA) with obesity, as well as to assess its safety.
- Trial name
- UNISHAPE-OSA-1 (NCT07767942)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Childhood Obesity
Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity
The aim of the present study is to identify new obesity-related genetic defects and determine their association with clinical manifestations in families with childhood-onset severe obesity.
- Trial name
- PeLi (NCT02645422)
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Morbid Obesity
Preventive Therapy With Ursodiol to Reduce the Incidence of Gallstones Formation in Patients After Bariatric Surgery
Risk factor of cholelithiasis is rapid weight loss after bariatric surgery and change in the gallbladder function which is secondary to surgery.
- Trial name
- NCT02319629
- Testing
- URSODIOL
- Where
- Israel
- Volunteers
- 266 people
- Sponsor
- HaEmek Medical Center, Israel
Morbid Obesity, Ventilation Therapy; Complications
Intubation of Obese Patients in the Operating Room With or Without Face Mask Ventilation
The aim of the study is to answer a daily question in the operating room: what is the safest technique for intubation of severe/morbid obese patients (BMI 35 or more).
- Trial name
- VENT OR NOT (NCT05930678)
- Testing
- No ventilation with face mask, Ventilation with face mask
- Where
- 13 sites in France
- Volunteers
- 725 people
- Sponsor
- Nantes University Hospital
Adolescent Obesity
SMART Use of Medication for the Treatment of Adolescent Severe Obesity
This study will examine the timing and sequence of using adjunct obesity pharmacotherapy for adolescents with severe obesity who do not respond to lifestyle modification therapy alone.
- Trial name
- SMART (NCT04007393)
- Testing
- Lifestyle Modification Therapy (LSMT), Phentermine Pill, Topiramate Pill
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Morbid Obesity
Banded Versus Non-banded Roux-en-y Gastric Bypass
A Roux-en-Y Gastric Bypass (RYGB) is on the long term not always successful in every patient because weight regain can occur. An intervention to prevent weight regain in the future is to place a silicone band (non-adjustable)…
- Trial name
- Bandolera (NCT02545647)
- Testing
- BRYGB
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Rijnstate Hospital
Pulmonary Atelectasis, Respiratory Tract Diseases
Influence of Different Physical Therapy Resources Application After Reduction Stomach Surgery
The aim of this study will be to investigate the effects of using physical therapy resources in the postoperative morbidly obese individuals undergoing gastroplasty.
- Conditions
- Pulmonary Atelectasis, Respiratory Tract Diseases, Pathological Conditions, Signs and Symptoms
- Trial name
- NCT01872663
- Testing
- Continuous positive airway pressure, Incentive spirometry, Breath Stacking
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Obesity, Critical Illness
Levofloxacin Pharmacokinetics (PK) in the Severely Obese
Obesity is known to affect the concentrations of certain medications in the body. Levofloxacin is a commonly used antibiotic. Based on what the investigators know about levofloxacin and how it moves through the body, obesity may…
- Trial name
- NCT00176306
- Testing
- Levofloxacin 750 mg IV
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joel Thompson, PhD
The Prevalence of Surgery for Small Bowel Obstruction After LGBP Procedure.
Internal Hernia After Laparoscopic Gastric Bypass
To see if closing the mesenteric defects created at a Laparoscopic Gastric Bypass is better than leaving them open.
- Trial name
- NCT01137201
- Testing
- Suturing of mesenteric defects
- Where
- Sweden
- Volunteers
- 2,507 people
- Sponsor
- Region Örebro County
Anorexia Nervosa, Bariatric Surgery
Comparison of the Effects of Weight Changes on Serum Adipokines in Patients Diagnosed With Anorexia Nervosa and Morbid Obesity
In this study, when patients diagnosed with AN started treatment and their weight increased by 10%; On the other hand, it was aimed to compare the changes in serum adipokine levels observed in morbidly obese patients before…
- Conditions
- Anorexia Nervosa, Bariatric Surgery, Weight Change, Body
- Trial name
- NCT04663919
- Testing
- Bariatric surgery-RYGB, Dietary intervention
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Morbid Obesity
Extending and Banding the Roux-en-Y Gastric Bypass
The Roux-en-Y gastric bypass (RYGB) has proven to be an effective treatment for morbid obesity by reducing weight and comorbidities. Extending the pouch may improve weightloss without the increase of complications.
- Trial name
- UPGRADE (NCT05357807)
- Testing
- Standard RYGB, Extended Pouch RYGB, Banded extended pouch RYGB
- Where
- 3 sites in Netherlands
- Volunteers
- 375 people
- Sponsor
- Rijnstate Hospital
Obesity, Morbid Obesity
Effectiveness and Tolerability of Phentermine in Patients Under Bariatric Surgery
Surgical management of Morbid Obesity is increasingly frequent. A low-calorie diet is recommended with the main goal of reducing intrahepatic fat infiltration, fat tissue and making easier the surgery.
- Conditions
- Obesity, Morbid Obesity, Bariatric Surgery, Non-alcoholic Fatty Liver
- Trial name
- NCT03849729
- Testing
- Phentermine
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Hospital Juarez de Mexico
Severe Obesity, Renal Failure
Obesity Surgery and Kidney Transplant for Patients With Obesity and Renal Failure
Gastric Bypass followed by renal transplantation is superior to medical management followed by renal transplant for patients with severe obesity and renal failure.
- Trial name
- NCT02128802
- Testing
- Gastric Bypass, Weight Loss Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Binge Eating Disorder Associated With Obesity, Binge Eating Disorder
Behavioral Therapy and GLP-1 Analogue Effects on Binge Eating, Weight, and Coping in Obesity
This study is a clinical, longitudinal, non-randomized, prospective observational study that seeks to compare the treatment effects and safety of using GLP-1 analogues versus not using appetite suppressants during a lifestyle…
- Conditions
- Binge Eating Disorder Associated With Obesity, Binge Eating Disorder, Eating Disorder Binge, Eating Disorders
- Trial name
- BETTER-GLP1 (NCT07042672)
- Testing
- GLP-1, CBTe Group Therapy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Haukeland University Hospital
Morbid Obesity
Prospective, Randomised Study: Metabolic and Functional Effects of Bariatric Surgery Accessed Using PET and MRI.
The objectives of this study are to measure effect of obesity on brain structure and molecular pathways, food-stimuli mediated brain activation response, on hormones affecting both feeding and energy balance as well as on bone…
- Trial name
- Sleevepet2 (NCT01373892)
- Testing
- Bariatric surgery
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity, Morbid, Insulin Resistance
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, Insulin Resistance and Central Reward System
Background: Morbid obesity is associated with decreased brain µ-opioid receptor availability, possibly resulting in higher food intake needed to gain pleasure from eating.
- Trial name
- BariBrainPET (NCT05080205)
- Testing
- Bariatric surgery
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Morbid Obesity
Laparoscopic Sleeve Gastrectomy With and Without Omentectomy
The investigators aim to determine the clinical and metabolic effects of sleeve gastrectomy with or without omentectomy in the treatment of morbid obesity.
- Trial name
- NCT00434525
- Testing
- Laparoscopic restrictive procedure, Sleeve gastrectomy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- North Texas Veterans Healthcare System