Clinical trials: Severe Obesity
Acute Kidney Injury, Arterial Hypertension
Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients
To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.
- Conditions
- Acute Kidney Injury, Arterial Hypertension, Obesity, Cardio Vascular Disease
- Trial name
- NCT02499185
- Testing
- Nephro Check Test, serum creatinine measurement
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Morbid Obesity
The Microbiology of Bariatric Surgery
Obesity and its associated diseases are increasing worldwide. However, the mechanisms behind the development of obesity is not fully understood.
- Trial name
- NCT03181347
- Testing
- RYGB, SG, Dietary and behavioral
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University of Alberta
Obesity, Childhood, Insulin Resistance
Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance
This is a 12-month, single center, three-arm parallel design, double-blind, randomized clinical trial, to compare the effects of supplemental dietary fiber and metformin (MET) alone and in combination over 12 months on glucose…
- Trial name
- NCT04578652
- Testing
- Metformin 850 mg oral tablet bid, Supplemental fiber mixture (35 g total) composed of 6g of Oligofructose + 12g of resistant maltodextrin + 12g of acacia gum + 5g of PGX.
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Alberta
Gastric Ulcer, Gastric Cancer
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients
Ciprofol is a new general anesthetic, which combine with γ- Aminobutyric acid-a (GABAA) receptor. Ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage.
- Conditions
- Gastric Ulcer, Gastric Cancer, Gastrointestinal Polyp
- Trial name
- SpO2 (NCT05518929)
- Testing
- Ciprofol, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,090 people
- Sponsor
- RenJi Hospital
Morbid Obesity
Laparoscopic Gastric Plication Compared With Laparoscopic Sleeve Gastrectomy
The study must be performed in 100 patients suffering from morbid obesity, the procedure will be performed under general anesthesia doing two or three layers of suture to achieves gastric imbrication until transform the stomach…
- Trial name
- LGP (NCT01293877)
- Testing
- Laparoscopy surgery for morbid obesity
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bikkur Holim Hospital
Obesity, Morbid Obesity
State of Obesity Care in Canada Evaluation Registry
The purpose of this study is to see whether care gap(s) exist in the management of obesity and its related conditions in obese patients seen by primary care physicians and specialists.
- Trial name
- NCT00328081
- Where
- Canada
- Volunteers
- 1,906 people
- Sponsor
- Hamilton Health Sciences Corporation
Obese Children and Adolescents
Topiramate and Severe Obesity
The purpose of this study is to evaluate the efficacy of Topiramate on the decrease of Body Mass Index compared to placebo at 9 months.
- Trial name
- TOBI (NCT02273804)
- Testing
- Topiramate
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diastolic Dysfunction, Morbid Obesity
Diastolic Dysfunction in Morbidly Obese Patients Undergo Bariatric Surgery
Morbidly obese patients are at risk for diastolic cardiac dysfunction, which can lead to adverse event, such as, diastolic heart failure postoperatively.
- Trial name
- NCT04128735
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Mahidol University
Morbid Obesity
Randomised Trial of Intensive Behavioral Lifestyle Intervention Versus Usual Preparation for Bariatric Surgery
Prospective randomized clinical trial aiming to compare a comprehensive, intensive behavioral lifestyle intervention and usual care during the preoperative preparation to bariatric surgery, with primary outcome on excess weight…
- Trial name
- PICO (NCT04282304)
- Testing
- Preoperative usual care, Preoperative intensive behavioral lifestyle intervention
- Where
- France
- Volunteers
- 17 people
- Sponsor
- IHU Strasbourg
Morbid Obesity
Bougie Sleeve Trial
Staple-line leak is the most frequent and incapacitating complication after laparoscopic sleeve gastrectomy (LSG). The aim of this prospective randomized trial is to compare the staple-line leak rate after LSG according to the…
- Trial name
- BOUST (NCT02937649)
- Testing
- Laparoscopic sleeve gastrectomy using 48-Fr bougie, Laparoscopic sleeve gastrectomy using standard care bougie
- Where
- 12 sites in France
- Volunteers
- 1,658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pain, Regional Anesthesia
EOIB for Laparoscopic Sleeve Gastrectomy
n obese patients, adequate pain relief in the postoperative period is a crucial parameter that affects patient comfort and hospital stay.
- Conditions
- Acute Pain, Regional Anesthesia, Morbid Obesity
- Trial name
- NCT07101835
- Testing
- Bilateral ultrasound guided external oblique intercostal block (EOIB), ıv morphine PCA
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ondokuz Mayıs University
Morbid Obesity, Metabolically Healthy Obesity
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Obesity
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with morbid obesity, metabolically healthy obesity and from healthy volunteers.
- Trial name
- BIOMIS-Endo (NCT04698135)
- Testing
- Biological samples collection, Questionnaire, Medical/laboratory examinations
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Obesity
Tolerance and Pharmacokinetic/Pharmacokinetic Study of IBI362 15mg in Patients With Moderate to Severe Obesity
This study is a multicenter, randomized, partially double-blind (double-blind in both the IBI362 group and the placebo group, with the tirbopeptide group open), placebo and active drug controlled design study
- Trial name
- NCT07000955
- Testing
- Tirzepatide, IBI362
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Diabetes Mellitus, Type 2, Gestational Diabetes
Mechanisms Behind Severe Insulin Resistance During Pregnancy in Women With Glucose Metabolic Disorders (SIR-MET)
The aim of this study is to describe the metabolic changes during pregnancy in women with type 2 diabetes or gestational diabetes in order to detect the pathophysiological mechanisms behind severe insulin resistance during…
- Conditions
- Diabetes Mellitus, Type 2, Gestational Diabetes, Overweight and Obesity, Pregnancy in Diabetic
- Trial name
- NCT04924504
- Testing
- No interventions
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Morbid Obesity
Efficiency of TISSEEL for Sleeve Gastrectomy Complications
Laparoscopic Sleeve Gastrectomy has emerged over the last 20 years as a treatment of choice in the surgical management of patients with morbid obesity.
- Trial name
- TISSEEL (NCT01613664)
- Testing
- tisseel, no tisseel
- Where
- 2 sites in France
- Volunteers
- 597 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Vitamin B12 Deficiency
Vitamin Deficiencies and Suppletion in Morbid Obesity
The purpose of this study is to evaluate the most effective treatment for patients who underwent a Roux-en-Y gastric bypass and developed postoperatively a vitamin B12 deficiency.
- Trial name
- NCT02270749
- Testing
- Hydroxocobalamin, FitForMe vitamin B12
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Rijnstate Hospital
Morbid Obesity, Anesthesia Complication
Low Flow Anesthesia in Morbid Obesity
In this study to planned to research the efficacy of low-flow anesthesia on patients undergoing sleeve gastrectomy due to morbid obesity on respiratory functions after surgery by examining FEV1 and FVC values and FEV1/FVC ratio.
- Conditions
- Morbid Obesity, Anesthesia Complication, Anesthesia; Functional
- Trial name
- NCT03913858
- Testing
- Obesity Surgery with Low-Flow Anesthesia, Obesity Surgery with High-Flow Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Type 2 Diabetes, Morbid Obesity
The Effect of a Gastric Bypass on Type 2 Diabetes in the Morbidly Obese Patient
Proof of concept, of RYGBP and its capabilities to cure type 2 diabetes (DM 2) and sleep apnea has already been recognized in the reports on weight loss surgery.
- Trial name
- NCT01086111
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Gasthuisberg
Morbid Obesity
Laryngeal Mask in Morbid Obesity
Investigators study the performance of both masks, Proseal Laryngeal Mask Airway (PLMA) and I-gel, as temporary ventilatory supraglottic airway devices (SGDs) before tracheal intubation in morbidly obese patients.
- Trial name
- NCT04243564
- Testing
- Supraglottic device (SGD)
- Where
- Italy
- Sponsor
- University of Padova