Clinical trials: Severe Obesity
Obesity
Signature Diagnostic of Non-alcoholic Steatohepatitis (NASH) by Infrared Light Spectroscopy
Evaluation of the diagnostic performance of an algorithm developed to detect metabolic profiles specific of non-alcoholic steatohepatitis NASH and based on the reading of a blood sample's infrared spectra
- Trial name
- SIGNALS (NCT03978247)
- Testing
- NASHMIR
- Where
- Belgium
- Volunteers
- 382 people
- Sponsor
- Diafir
Obesity, Metabolic Syndrome
Prospective Cohort Study of the Effect of Bariatric/Metabolic Surgery on Morbid Obesity Patients With Metabolic Syndrome
The purpose of this study is to determine the change in kidney function and blood pressure after gastric bypass versus conventional medical therapy in morbid obesity.
- Trial name
- NCT02271568
- Testing
- Bariatric surgery, Intensive medical therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Hanyang University
Morbid Obesity
McGrath Videolaryngoscopy and Direct Laryngoscopy in Morbidly Obese Patients
Our goal is to compare conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for endotracheal intubation in very morbidly obese patients undergoing non-cardiac surgery.
- Trial name
- NCT03467048
- Testing
- McGrath videolaryngoscopy, Direct laryngoscopy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- The Cleveland Clinic
Obesity, Morbid Obesity
Lifestyle Intervention Feasibility for Arrhythmia and Symptoms With Intermittent Fasting (LIFE AS IF)
BACKGROUND AND RATIONALE Two out of three Americans are overweight and obesity is associated with hypertension, sleep apnea, atrial fibrillation.
- Conditions
- Obesity, Morbid Obesity, Diabetes Mellitus, Type 2, Atrial Fibrillation
- Trial name
- LIFE AS IF (NCT04090840)
- Testing
- Intermittent Fasting
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Chicago
Obesity
Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population.
MAIN OBJECTIVE To compare the effects of the placement of an adjustable gastric band with "conventional" treatment of obesity. SECONDARY OBJECTIVES Compare the effects of the placement of a gastric band with "conventional"…
- Trial name
- CHADO (NCT01700738)
- Testing
- gastric ring surgery, nutritional help
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Mechanical Ventilation Complication, Respiratory Insufficiency
Transpulmonary Pressures in Mechanical Ventilated Patients With Morbid Obesity
The study consists in determine the transpulmonary pressure in morbidly obesity patients that require mechanical ventilation. both gender only adults Medical intensive care patients.
- Trial name
- NCT02309190
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity, Nonalcoholic Steatohepatitis
Controlled Trial of WLS vs. CLI for Severely Obese Adolescents With NASH
The goal of this study is to determine effective treatment and identify diagnostic biomarkers for Nonalcoholic steatohepatitis (NASH).
- Conditions
- Obesity, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease
- Trial name
- NCT02412540
- Testing
- Comprehensive Lifestyle Intervention
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Metabolic Syndrome, Morbid Obesity
Omentectomy and Metabolic Syndrome
The aim of the present study was to evaluate the additional effect of sudden visceral fat reduction by omentectomy on Metabolic Syndrome, acute phase reactants and inflammatory mediators in patients with morbid obesity undergoing…
- Trial name
- NCT00923260
- Testing
- Laparoscopic Roux-en-Y Gastric Bypass, Omentectomy
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Endoscopic Sleeve Gastroplasty
Endoscopic Sleeve Gastroplasty for Morbid Obesity
Obesity and its related metabolic disorders are increasingly a heavy health burden to many parts of the world. Weight control is a well-known important step in avoiding type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03124485
- Testing
- Endoscopic Sleeve Gastroplasty, Laparoscopic Sleeve Gastrectomy
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Chinese University of Hong Kong
Bariatric Surgery Candidate
Study to Compare the Bioavailability of Omeprazole 20 mg Before and After Undergoing Surgery for Morbid Obesity
The principal aim was to evaluate whether gastric bypass surgery modifies the bioavailability of omeprazole 20 mg at one month and six months after surgery.
- Trial name
- OBS-2011/001 (NCT03378960)
- Testing
- Omeprazole 20mg
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Emilio Vargas Castrillón
Morbid Obesity, Neuromuscular Blockade
Comparative Study of Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Morbidly Obese Patients
Postoperative residual curarization in the post anaesthesia unit has been associated to complications involving respiratory function and impaired laryngeal and pharyngeal muscles' function.
- Trial name
- NCT01629394
- Testing
- Sugammadex, Neostigmine
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Patras
Respiratory Complication, Morbid Obesity
Does Residual Muscular Weakness Lead to an Increase in Respiratory Complications in Bariatric Patients?
The purpose of this study is to determine if residual weakness after weight loss surgery leads to an increased risk of respiratory complications in the postoperative period.
- Trial name
- NCT02037516
- Testing
- Accelomyography, Neostigmine, Qualitative Monitor
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Coastal Anesthesiology Consultants
Osteoarthritis of Knee, Arthroplasties, Knee Replacement
Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?
The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery.
- Conditions
- Osteoarthritis of Knee, Arthroplasties, Knee Replacement, Sleeve Gastrectomy
- Trial name
- NCT06767787
- Testing
- laparoscopic sleeve gastrectomy, total knee arthroplasty
- Where
- 2 sites in Canada
- Volunteers
- 142 people
- Sponsor
- Memorial University of Newfoundland
Morbid Obesity, Bariatric Surgery Candidate
Analgesia Management in Bariatric Surgery
Following laparoscopic bariatric surgery, multimodal analgesia is recommended to avoid the adverse effects of opioids by reducing their use.
- Conditions
- Morbid Obesity, Bariatric Surgery Candidate, Pain, Postoperative
- Trial name
- NCT04836819
- Testing
- Lidocain, Ketamine, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Ondokuz Mayıs University
Severely Obese Patients
Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function
Growing evidence suggests that bariatric surgery is a relevant treatment for severely obese patients, especially those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic…
- Trial name
- NCT01284816
- Testing
- bariatric surgery
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Morbid Obesity
Usefulness and Safeness Of Intra-Gastric Balloon Before Bariatric Surgery In Morbid Obesity
Introduction: bariatric surgery shows an important morbidity and there are some reports that have used preoperative intragastric-balloons (IGB-BIB®) to decrease surgical morbidity.
- Trial name
- NCT01998243
- Testing
- Intragastric Balloon (IGB), group A, diet, control group B
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Hospital Severo Ochoa
Morbid Obesity
Micafungin Pharmacokinetics in Obese Patients
Because micafungin is generally well tolerated and appears to have limited interaction with other drugs, it is a potential important agent in the treatment of invasive fungal infections.
- Trial name
- MICADO (NCT03102658)
- Testing
- Micafungin
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Morbid Obesity
Hunger/Satiety's Physiopathologic Study in Morbidly Obese Patients
The mechanisms that regulate appetite in the morbidly obese are multifactorial and not well-known. Different peripheral signals (such as ghrelin or cholecystokinin) play an important role in the central regulation of appetite and…
- Trial name
- NCT02414893
- Testing
- Sleeve gastrectomy
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari del Maresme
Morbid Obesity
Treatment of Low Metabolic Rate Following Bariatric Surgery
Purpose is to determine the effect of ephedrine and caffeine, on metabolic rate and weight loss after bariatric surgery. Approximately 40% of patients struggle with their weight loss rate, or metabolic rate, after bariatric…
- Trial name
- NCT01596907
- Testing
- Ephedrine sulfate with caffeine, cellulose
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Oregon Weight Loss Surgery, LLC
Postoperative Complications, Gastric Bypass
Perioperative Nutrition in Gastric Bypass Surgery
The aim of this study is to demonstrate the influence of peri-operative nutrition on the preservation of lean body mass after gastric bypass, as well as it's influence on postoperative complications.
- Trial name
- NCT00549237
- Testing
- Glucose load (Nutricia), Post operative early enteral feeding
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva