Clinical trials: Severe Obesity
Obesity, Gastric Reflux
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric…
- Conditions
- Obesity, Gastric Reflux, Ulcer, Gastric
- Trial name
- NCT05320796
- Testing
- upper endoscopy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Prof Urs Zingg
Adipose Tissue Inflammation, Morbid Obesity
n-3 Polyunsaturated Fatty Acids in Obesity
Inflammation in the adipose (fat) tissue is an important condition leading to metabolic derangements and cardiovascular disease in obese patients.
- Trial name
- PUFA-ATI (NCT00760760)
- Testing
- reesterified long-chain n-3 polyunsaturated fatty acids (EPA, DHA), control
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Medical University of Vienna
Anesthesia, Regional Anesthesia
Laparoscopic Sleeve Gastrectomy Surgery and External Oblique Intercostal Block
In obese patients, adequate pain relief in the postoperative period is an important parameter that affects patient comfort and hospital stay.
- Conditions
- Anesthesia, Regional Anesthesia, Morbid Obesity, Postoperative Pain
- Trial name
- NCT05822479
- Testing
- Bilateral ultrasound guided external oblique intercostal block (EOIB), Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Preeclampsia, Hypertensive Disorder of Pregnancy
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
This is a single site, single-blinded parallel randomized control trial that investigates a multi-level intervention to improve postpartum blood pressure in women with hypertensive disorder pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Toxemia, Pregnancy Complications
- Trial name
- HHD (NCT05655936)
- Testing
- Heart Health Doula Intervention Program, Usual Care
- Where
- United States
- Volunteers
- 454 people
- Sponsor
- University of Pittsburgh
Obesity, Morbid Obesity
Bariatric Surgery for Morbid Obesity
Despite progress in understanding the pathophysiology of obesity, current strategies for its medical management remain largely ineffective.
- Trial name
- NCT00675558
- Testing
- Initial Surgery, Second Bariatric Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Morbid Obesity, Metabolic Disease
Study Evaluating Metabolic Syndrome in Subjects Undergoing Gastric Bypass Bariatric Syndrome
Metabolic syndrome is rapidly emerging as an epidemic of global proportions and its definition is still evolving. Patients with this syndrome are at increased risk for cardiovascular disease, and at increased risk of mortality…
- Trial name
- NCT00283374
- Testing
- Laparoscopic Roux-en-Y Gastric Bypass
- Where
- 17 sites in United States, Italy and 1 more
- Volunteers
- 120 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Morbid Obesity
Prospective Case-Series of Ligasure Advance Pistol Grip and LigaSure Blunt Tip
The study is primarily to evaluate the safety and efficacy of the LigaSure Advance™ Pistol Grip and LigaSure™ Blunt Tip using the Force Triad™ Energy Platform during Roux-en-Y and gastric reduction procedures (sleeve gastrectomy…
- Trial name
- NCT01759550
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Duke University
Obesity, Morbid Obesity
Safety Evaluation of the LGL102 in Obese Subjects Treated With OMS102
The main objective of this study is to evaluate the LGL102 implant safety in obese to morbidly obese subjects treated with OMS102 system. The effect of the therapy on body weight changes will be also evaluated.
- Trial name
- NCT01539850
- Testing
- OMS102
- Where
- 3 sites in Germany
- Volunteers
- 34 people
- Sponsor
- IntraPace, Inc
Pain, Postoperative, Morbid Obesity
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
The purpose of this study is to determine if pre-incisional lidocaine injection, instilled liquid bupivacaine, intra-abdominal aerosolized bupivacaine, or post-operative bupivacaine injection is superior in post-operative pain…
- Trial name
- NCT00508976
- Testing
- Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pinnacle Health System
Steatohepatitis, Morbid Obesity
Transoral Endoscopic Liver Biopsy During Laparoscopic Gastric Bypass
This research is being done to evaluate the ability to obtain a liver sample using upper endoscopy rather than through a laparoscopic procedure.
- Trial name
- NCT00512512
- Testing
- Transoral Endoscopic Liver Biopsy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity
Study Examining The Effect Of Renal Impairment On Safety, Toleration And How The Body Processes An Experimental Drug
CP-945,598 is eliminated following extensive metabolism. For some drugs, decreased renal (kidney) function can affect their elimination from the body via metabolism.
- Trial name
- NCT00472836
- Testing
- CP-945,598
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
Morbid Obesity
Gastric Procedures for Obesity
This is a prospective case series study; all morbidly obese patients that need surgical management in Royal Alexandra Hospital will be provided 3 surgical options: Laparoscopic Sleeve Gastrectomy (LSG), laparoscopic Roux-en-Y…
- Trial name
- NCT01026181
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Morbid Obesity, Bariatric Surgery
LAGB Versus VBG: 7-Year Results
The study aims to investigate the long term results of a randomized clinical single-centre trial comparing two standard operative techniques in bariatric surgery; laparoscopic adjustable gastric banding and vertical banded…
- Conditions
- Morbid Obesity, Bariatric Surgery, Vertical Banded Gastroplasty, Laparoscopic Adjustable Gastric Banding
- Trial name
- NCT00840736
- Testing
- Laparoscopic adjustable gastric banding, vertical banded gastroplasty
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
POMC Deficiency Obesity, PCSK1 Deficiency Obesity
An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes
This is an observational study. There are no protocol-defined visits, although patients are expected to have routine office visits approximately every 6 months.
- Conditions
- POMC Deficiency Obesity, PCSK1 Deficiency Obesity, LEPR Deficiency Obesity
- Trial name
- NHS (NCT03621007)
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 8 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Morbid Obesity
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, and Activation of Central Reward System
Background: The investigators have found that obesity and insulin resistance result in significantly increased brain insulin-stimulated glucose uptake, whereas in every other tissue glucose uptake is lower in the obese compared…
- Trial name
- BARIBRAIN (NCT04343469)
- Testing
- Bariatric Surgery (RYGB or LSG)
- Where
- 2 sites in Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Obesity
Effects of Self-conditioning Techniques in Promoting Weight Loss in Patients With Obesity. A Randomized Controlled Trial
The investigators hypothesized that hypnosis is an alternative technique that could be applied to help patients with obesity to lose weight.
- Trial name
- NCT02978105
- Testing
- self-conditioning techniques, standard care (diet, exercise and behavioral therapy)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Turin, Italy
Morbid Obesity
Oseltamivir Pharmacokinetics in Morbid Obesity
This trial asks the question: do people of much greater than average body weight need more of a drug called oseltamivir than current recommendations suggest.
- Trial name
- OPTIMO (NCT01002729)
- Testing
- Patients with a BMI < 30 given Oseltamivir, Patients with a BMI > 40 given Oseltamivir
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Endometrial Cancer, Extreme Obesity
Transvaginal Natural Orifice Endoscopic Surgery for Extremely Obese Patients With Early-stage Endometrial Cancer
The aim of this study is to investigate the feasibility and efficacy of the v-NOTES approach for extremely obese patients with early-stage type 1 endometrial cancer.
- Trial name
- NCT04240730
- Testing
- Transvaginal natural orifice endoscopic surgery for endometrial cancer staging
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Bariatric Surgery Candidate, Severe Obesity
Single Anastomosis Duodenal Ileal Bypass (SADI) for Sleeve Revision
The goal of this study is two part: 1) to add to the literature which is still somewhat sparse with numbers of patients undergoing the Single Anastomosis Duodenal Ileal Bypass (SADI) as a revision for laparoscopic sleeve…
- Trial name
- SADI (NCT04165694)
- Testing
- Single Anastomosis Duodenal Ileal Bypass (SADI)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente