Clinical trials: Severe Obesity
Morbid Obesity
The Effects of Exenatide After Gastric Restriction
The purpose of this study is to describe change in body weight in non-diabetic morbidly obese patients after laparoscopic adjustable gastric banding (LAGB) with twice daily exenatide or placebo injections.
- Trial name
- AGREE (NCT00872378)
- Testing
- Exenatide
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Advanced Specialty Care
Obesity
Influence of Plantago Major on Mineral Metabolism and Selected Biochemical Parameters in Obese Women
Effect of oral supplementation with Plantago major on cardiometabolic risk factors and mineral content and lifestyle in obese women: double-blind, randomized clinical trial.
- Trial name
- Plantago (NCT03439540)
- Testing
- Plantago major
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Periodontal Diseases, Obesity, Morbid
Gingival Crevicular Fluid of Adiponectin and Resistin As Predictable Implement in Staging and Grading System of Periodontitis
The goal of this clinical trial is to evaluate the relationship between obesity and gingival crevicular fluid resistin and adiponectin in periodontitis patients as well as assess the effect of non-surgical periodontal therapy on…
- Trial name
- NCT06604013
- Testing
- non-surgical full-mouth periodontal therapy without using adjunct disinfectants, GCF level of adiponectin and resistin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Morbid Obesity, Type 2 Diabetes Mellitus
Caloric Restriction and Insulin Secretion
Caloric restriction in obese diabetic patients quickly improves glucose control, independently from weight loss. However, the early effects of a very-low calorie diet (VLCD) on insulin sensitivity and insulin secretion in…
- Trial name
- NCT01447524
- Testing
- Very Low Calorie Diet
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Rome Tor Vergata
Morbid Obesity, Weight Loss
Intraoperative Measuring of Small Bowel Length Compared to Measuring by Magnetic Resonance Imaging (MRI) in Morbid Obese Patients
An important step during a gastric bypass operation for the treatment of morbid obesity is the measuring of the small bowel length.
- Trial name
- NCT00740662
- Testing
- Distal gastric bypass
- Where
- 2 sites in Switzerland
- Volunteers
- 7 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Morbid Obesity
Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function
Gastric bypass surgery is the gold standard in bariatric surgery and is a successful method to reduce weight in morbidly obese subjects.
- Trial name
- OLIVIER (NCT02206256)
- Testing
- Omega-3 fatty acid capsules, Low calorie diet
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Medical Center Alkmaar
Iron Deficiency Anemia, Obesity
Iron Supplementation and Anemia After Sleeve Gastrectomy
The goal of this observational study is to learn if taking extra iron pills after weight loss surgery helps prevent low iron and anemia compared to just taking a standard multivitamin.
- Conditions
- Iron Deficiency Anemia, Obesity, Sleeve Gastrectomy
- Trial name
- NCT07397572
- Testing
- Elemental Iron, Multivitamin with Minerals
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Obesity & Overweight, Hair Loss
Scalp Hair Metabolomics in Severe Obesity
The purpose of this research study is to investigate how body weight and weight-loss surgery affect the natural chemicals found in scalp hair over time.
- Conditions
- Obesity & Overweight, Hair Loss, Metabolomics, Bariatric Surgery
- Trial name
- NCT07368842
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Obesity, Morbid Obesity
Comparing Dumping Symptoms and Quality of Life 6 Months After Sleeve Gastrectomy With or Without Transit Bipartition in Adults With Obesity
This clinical study aims to compare two types of bariatric (weight loss) surgery used to treat obesity: sleeve gastrectomy alone and sleeve gastrectomy with transit bipartition.
- Conditions
- Obesity, Morbid Obesity, Dumping Syndrome, Postgastrectomy Syndrome
- Trial name
- STuD-QoL (NCT07263269)
- Testing
- Sleeve Gastrectomy, Sleeve Gastrectomy with Transit Bipartition
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mina Kamal Gergis Erian
Obesity
Monitoring Patients With Severe Obesity Treated With Wegovy® Using Connected Device: Real-world Data
This study involves collecting real-world data on body weight, body composition, cardiovascular parameters, and neurovegetative parameters using a connected scale in patients with severe obesity treated with Wegovy®.
- Trial name
- TELE-SEMA (NCT06426446)
- Testing
- Withings Body Comp Pro
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, Antibody COVID-19
The Role of Obesity in Severe COVID-19 Pathophysiology
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide.
- Trial name
- SAMO (NCT06968442)
- Testing
- Venipuncture
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Franciscus Gasthuis
Obesity, Morbid, Obesity and Overweight
The Effect of Laparoscopic Sleeve Gastrectomy on Blood Phoenixin-14 Levels
Obesity is a major global health concern with a rising prevalence and numerous associated comorbidities. For the treatment of severe obesity, bariatric surgery stands as the most effective procedure.
- Trial name
- Morbid Obesity (NCT07004556)
- Testing
- Preoperative blood sampling for determining Phoenixin 14 levels, Postoperative blood sampling for determining Phoenixin 14 levels
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Morbid Obesity
SAS-J Compared to OAGB and LSG as a Treatment for Morbid Obesity
150 morbidly obese patients divided into to equal groups, group A underwent single anastomosis sleeve jejunal bypass and group B underwent mini gastric bypass, group C underwent sleeve gastrectomy.
- Trial name
- NCT03821688
- Testing
- SAS-JB, OAGB, LSG
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Minia University
Obesity, Morbid Obesity
Studies of Biological Changes Related to Weight Loss After Gastric Bypass Surgery
Weight loss achieved by dieting induces multiple changes. These changes include a decrease in metabolic rate (the rate in which the body burns its calories), an increase in appetite and other physiological and hormonal changes…
- Conditions
- Obesity, Morbid Obesity, Weight Loss
- Trial name
- NCT00120562
- Testing
- Gastric Bypass Surgery
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Rockefeller University
Severe Adolescent Obesity, Adolescent Obesity
Comparison of Day Hospitalization Versus Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity
This multicenter prospective quasi-experimental study aims to compare the effectiveness of day hospitalization versus full-time hospitalization for adolescents with severe obesity.
- Conditions
- Severe Adolescent Obesity, Adolescent Obesity, Pediatric Obesity
- Trial name
- MAROSA (NCT07652190)
- Testing
- Day Hospital Multidisciplinary Care, Full-Time Inpatient Multidisciplinary Care
- Volunteers
- 126 people
- Sponsor
- Fondation Santé des Étudiants de France
Morbid Obesity
Intake of Omega 3 in Morbidly Obese Patients
Ingestion of capsules of omega 3 EPA and DHA, with 1.8 g of EPA and 1.2 g DHA for morbidly obese patients, will improve the inflammatory status? C-reactive protein? Weight?
- Trial name
- NCT02113696
- Testing
- Omega 3 intake, morbid obesity
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Obesity, Childhood
Vyvanse in Children Aged 6 to 12 Years
This study will randomize children who have difficulty maintaining a healthy weight to one of two treatment groups: lifestyle therapy plus lisdexamfetamine or lifestyle therapy plus placebo.
- Trial name
- NCT05416125
- Testing
- Lisdexamfetamine Dimesylate, Lifestyle therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Morbid Obesity
Taste Perception Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery, gastric bypass lap banding, and sleeve gastrectomy. The surgery is not part of the clinical trial.
- Trial name
- RBtaste (NCT01536197)
- Testing
- Gastric bypass, Gastric banding, Sleeve gastrectomy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine