Clinical trials: Severe Obesity
Obesity, Morbid, Bariatric Surgery Candidate
Exercise Following Bariatric Surgery for Severe/Morbid Obesity (EFIBAR)
Severe/morbid obesity is an international public health issue that importantly increases the risk of cardiovascular events and cardiovascular and all-cause mortality.
- Trial name
- EFIBAR (NCT03497546)
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Universidad de Almeria
Morbid Obesity, NAFLD
Sleeve Gastrectomy in Adolescents With Complicated Morbid Obesity and NAFLD
Pediatric obesity has become a critical health problem worldwide, increasing the premature onset of obesity-related morbidities.
- Trial name
- NCT02564679
- Testing
- Laparoscopic Sleeve gastrectomy (LSG), Lifestyle Intervention
- Volunteers
- 40 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Obesity, Insulin Resistance
Insulin Resistance in Severely Obese Patients
This study aims to understand the biological processes that link obesity to diseases including insulin resistance and diabetes. Our approach involves studying the health of patient undergoing weight loss either via weight…
- Conditions
- Obesity, Insulin Resistance, Diabetes
- Trial name
- NCT00275223
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Effects of Lipids on Gastric Emptying, Effects of Lipids on Satiety Hormones
Effects of Lipids on Gastric Emptying, Satiety Hormones, and Appetite in Severe Overweight
In lean subjects, free fatty acid (FFA) promotes gut hormone release, delays gastric emptying, and reduces appetite and energy intake more than an isocaloric load of triglyceride (TG).
- Conditions
- Effects of Lipids on Gastric Emptying, Effects of Lipids on Satiety Hormones, Effects of Lipids on Appetite
- Trial name
- NCT01681459
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Morbid Obesity
Bariatric Procedures and Changes in Incretins and Gastric Emptying
The study evaluates the gastric emptying by scintigraphy in patients that had bariatric surgery (RYGB of gastric sleeve) comparing patients with successful and unsuccessful weight loss and in patients before and after the…
- Trial name
- BIG (NCT02539641)
- Testing
- Gastric emptying scintigraphy, Determination of gut hormones
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Rijnstate Hospital
Obesity, Morbid
Safety and Effectiveness Study of The Swedish Adjustable Gastric Band (SAGB) in the Treatment of Morbid Obesity
The purpose of this study is to determine whether the Swedish Adjustable Gastric Band (SAGB) is safe, and effective in achieving weight loss in patients with Morbid Obesity.
- Trial name
- NCT00166205
- Testing
- Swedish Adjustable Gastric Band
- Where
- 12 sites in United States
- Volunteers
- 276 people
- Sponsor
- Ethicon Endo-Surgery
Metabolic Syndrome, Severe Obesity
Endoscopic Conversion of Sleeve Gastrectomy to Single Anastomosis Sleeve-ileal Bypass (SASI) for Gastroesophageal Reflux (GERD), Primary and Secondary Non-responder.
The aim of this study is to determine the feasibility and effectiveness of endoscopic anastomosis of sleeve gastrectomy to ileum with a lumen apposing metal stent (LAMS) after a failed sleeve gastrectomy.
- Conditions
- Metabolic Syndrome, Severe Obesity, Reflux, Gastroesophageal, Bariatric Surgery
- Trial name
- NCT06757296
- Testing
- Endoscopic SASI
- Where
- 3 sites in Singapore
- Volunteers
- 500 people
- Sponsor
- Singapore Health Services
Morbid Obesity
Evaluation of Endostapled Anastomoses for Laparoscopic Gastric Bypass (EEA-LGB)
Laparoscopic gastric bypass surgery is a common procedure being performed for the treatment of morbid obesity. The procedure consists of a creation of a small gastric pouch and rerouting the small bowel to bypass the stomach and…
- Trial name
- EEA-LGB (NCT00254072)
- Testing
- 3.5 mm vs 4.8 mm Stapler During Laparoscopic Gastric Bypass
- Where
- 6 sites in United States
- Volunteers
- 355 people
- Sponsor
- University of California, Irvine
Intra-Operative Injury - Other, Post Operative Hemorrhage
Preoperative Hexakapron Reduces Bleeding in Bariatric Surgery
Prophylactic use of tranexamic acid to reduce intra and postoperative bleeding in primary sleeve gastrectomy procedures will be studied.
- Conditions
- Intra-Operative Injury - Other, Post Operative Hemorrhage, Tranexamic Acid
- Trial name
- PHORBBS (NCT03085394)
- Testing
- tranexamic acid
- Where
- Israel
- Volunteers
- 152 people
- Sponsor
- Sheba Medical Center
Morbid Obesity, Vitamin D Deficiency
Effect of a Monthly High Dose of Vitamin D3 on Bariatric Surgery Patients
Bariatric surgery patients tend to have malabsorption of many micronutrients such as B12, Iron and vitamin D postoperative. So in this study, a monthly high dose of vitamin D3 is giving to patients with their routine supplements…
- Trial name
- NCT02477956
- Testing
- vitamin D3 (Replesta), vitamin D
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Texas Tech University
Morbid Obesity
The Efficacy of an Inpatient Program for Long-term Weight Maintenance in Children and Adolescents With Morbid Obesity
The major problem in the treatment of morbidly obese children is the long term maintenance of the reduced weight. Maintenance-focused interventions have not been studied enough in adolescents with morbid obesity, neither in…
- Trial name
- NCT01254266
- Testing
- inpatient hospitalization and follow up, inpatient treatment and follow up, bariatric surgery
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
Hypogonadism, Severe Obesity
Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot)
After the age of 40, there is a gradual decline in the production of testosterone. Among obese men, the decline in testosterone levels is exacerbated by the suppression of the hypothalamic-pituitary-gonadal axis by…
- Trial name
- NCT02959853
- Testing
- Anastrazole, weight loss
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Morbid Obesity
Effect of Liraglutide on Weight Loss in Patients Who Have Undergone Revisional Bariatric Surgeries.
Our primary objective is to assess the effect of Liraglutide on weight loss in patients who have undergone secondary bariatric surgeries.
- Trial name
- NCT05285397
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain
Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.
The goal of this randomized clinical trial is to find out whether giving an intravenous lidocaine + dexmedetomidine combination (LIDEX) during laparoscopic bariatric surgery can lower post-operative pain, inflammation, and…
- Conditions
- Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative Analgesia
- Trial name
- NCT07073846
- Testing
- Intravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia
- Where
- 2 sites in Mexico
- Volunteers
- 104 people
- Sponsor
- Instituto Mexicano del Seguro Social
Morbid Obesity, Obstructive Sleep Apnea
Laparoscopic Adjustable Gastric Banding With Truncal Vagotomy
Laparoscopic Adjustable Gastric Banding (LAGB) is a gold standard in the surgical treatment of morbid obesity. We hypothesize that the addition of truncal vagotomy (cutting of nerves to the stomach) will produce greater weight…
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea, Hypertension, Urinary Incontinence
- Trial name
- NCT00329862
- Testing
- Laparoscopic Truncal Vagotomy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Central Carolina Surgery, PA
Obesity and Overweight, Obese Adolescents
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3).
- Conditions
- Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
- Trial name
- MODERN (NCT06967389)
- Testing
- Ozempic®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Bauer
Obesity, Bariatric Surgery
Protein Need and Interest of " Quick Proteins " to the Obese Subject Operated by Bariatric Surgery (BIBOP)
The main objective of the study is to evaluate the protein requirement associated with postoperative weight loss caused by by-pass (shunt which leads to a certain degree of malabsorption) or sleeve gastrectomy (more technically…
- Trial name
- BIBOP (NCT01249326)
- Testing
- bariatric surgery
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypogonadism, Hypogonadotropic, Obesity
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism
The investigators have preliminary data suggesting that obese patients with hypogonadotropic hypogonadism (HHG) have minimal benefit from testosterone therapy likely because of its conversion to estradiol by the abundant…
- Trial name
- NCT03490513
- Testing
- anastrozole (1 mg/day)
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Baylor College of Medicine
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Body Weight Changes
Prediction of Response to Bariatric Surgery in Patients With Severe Obesity
This is an retrospective and prospective (ambispective) study with data collection from volunteer patients who passed an MMPI-2-RF (Minnesota Multiphasic Personality Inventory-2-Restructured form) questionnaire in the…
- Trial name
- PREDI-CHIRBA (NCT06426290)
- Testing
- post-surgery psychological evaluation
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier de Moulins Yzeure