Clinical trials: Severe Obesity
Morbid Obesity
Sleeve Gastrectomy: Outcome, Morbidity and Mortality. A Multicentric Retrospective Trial
Laparoscopic sleeve gastrectomy (LSG) is currently the most frequent primary bariatric procedure performed worldwide. LSG is a safe and effective technique in terms of excess weight loss and it is, moreover, a powerful metabolic…
- Trial name
- PSICHE (NCT04643262)
- Testing
- Sleeve Gastrectomy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Sleep Apnea Syndromes, Overweight and Obesity
A Single Centre, Prospective Feasibility Study to Evaluate the Efficacy of an Endoluminal-suturing Device (Endomina) on Severe Obstructive Sleep Apnea Syndrome
This study aims to evaluate the efficacy of an endoluminal gastric plication using an endoluminal-suturing device to improve severe OSAS in patients with a BMI above or equal to 28 kg/m² until 34.9kg/m².
- Trial name
- EndoSAS (NCT04979234)
- Testing
- Endomina- Endoscopic Sleeve Gastroplasty, Diet
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Erasme University Hospital
Morbid Obesity
Utilization of Very Low Calorie Diet in Obese General Surgery Patients
The investigators are studying the use of a two-week very low calorie diet (VLCD) in obese general surgery patients in a randomized single-blinded trial.
- Trial name
- NCT03553849
- Testing
- Very low calorie diet
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Opioid Use, Unspecified, Bariatric Surgery Candidate
Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids
The goal of this clinical trial is to compare Opioid Free and Opioid Based Anaesthesia in patients undergoing sleeve gastrectomy.
- Trial name
- NCT05752799
- Testing
- Opioid Free Anaesthesia, Opioid based anesthesia
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- G.Gennimatas General Hospital
Obesity, Diabetes Mellitus Type 2
Effect of the Omentectomy on the Hyperglycemia and the Resistance to the Insulin in Patients With Morbid Obesity
To determine if the omentectomy diminishes hyperglycemia and improves the resistance to the insulin in patients with morbid obesity and propensity to develop to Diabetes Mellitus type 2.
- Trial name
- omentectomy (NCT00454597)
- Testing
- omentectomy
- Where
- Mexico
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Glycine Metabolism Disturbances, Insulin Resistance
Obesity-Related Glycine Deficiency: Investigating a Long-standing Metabolic Paradox Using Bedside and Bench Approaches
Obesity, in addition to causing abnormal glucose and lipid metabolism, is also associated with altered plasma concentrations of multiple amino acids, including increased levels of branched-chain amino acids and decreased levels…
- Conditions
- Glycine Metabolism Disturbances, Insulin Resistance, Morbid Obesity, Oxidative Stress
- Trial name
- NCT04660513
- Testing
- Bariatric surgery
- Where
- Singapore
- Volunteers
- 42 people
- Sponsor
- Singapore General Hospital
Morbid Obesity
Laparoscopic Revision of an Enlarged Gastric Outlet After Gastric Bypass
The purpose of this study is to determine if laparoscopic plication of a gastrojejunostomy is an effective surgical option for the Roux-en-Y gastric bypass patient who has regained weight due to a dilated gastric stoma.
- Trial name
- NCT01116284
- Testing
- Revision of gastric bypass
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Baystate Medical Center
Morbid Obesity, Vertical Sleeve Gastrectomy
Metabolic Syndrome, Bile Acids, Hepatocellular Carcinoma and Cholangiocarcinoma
Increasing rates of highly malignant hepatocellular carcinoma (HCC) and biliary tract cancers (GBTC) observed in Western populations may be related to obesogenic lifestyle factors and their metabolic consequences, such as…
- Conditions
- Morbid Obesity, Vertical Sleeve Gastrectomy, Metabolic Syndrome, Hepatocellular Carcinoma
- Trial name
- METSLIVER (NCT02730611)
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplantation, Obesity
Sleeve Gastrectomy for Morbid-Obesity Sequelae After Transplantation
Complications associated with excess weight (hypertension, coronary artery disease and diabetes) have become major causes of morbidity and mortality after liver transplantation (LT).
- Trial name
- SG-4MOST (NCT03617744)
- Testing
- Sleeve gastrectomy
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Morbid Obesity
Preoperative PPI in Sleeve Gastrectomy
he purpose of this study is to study the effect of preoperative PPI in the early outcome of sleeve gastrectomy
- Trial name
- NCT03305432
- Testing
- sleeve + preoperative PPI
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Minia University
Severe Obesity
Resting Metabolic Rate is a Predictor of Weight Regain?
he increasing prevalence of obesity in developed countries has also reached Brazil in the last two decades. Conventional treatments are not efficient to sustained weight loss and in some cases, weight reduction in individuals…
- Trial name
- NCT04118582
- Testing
- Body composition and resting metabolic rate analisys
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Bariatric Surgery, Bone Health
Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
Background: Bariatric surgery is gaining in popularity. While it's health benefits are undisputed, the older malabsorptive bariatric procedures (Roux-in-Y gastric bypass - RYGB and biliopancreatic diversion - BPD) are associated…
- Conditions
- Bariatric Surgery, Bone Health, Severe Obesity, Muscle Health
- Trial name
- BONUS (NCT06547515)
- Testing
- Bariatric surgery
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- CHU de Quebec-Universite Laval
Severe Adolescent Obesity, Adolescent Obesity
Comparison of Day Hospitalization Versus Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity
This multicenter prospective quasi-experimental study aims to compare the effectiveness of day hospitalization versus full-time hospitalization for adolescents with severe obesity.
- Conditions
- Severe Adolescent Obesity, Adolescent Obesity, Pediatric Obesity
- Trial name
- MAROSA (NCT07652190)
- Testing
- Day Hospital Multidisciplinary Care, Full-Time Inpatient Multidisciplinary Care
- Volunteers
- 126 people
- Sponsor
- Fondation Santé des Étudiants de France
Obesity, Morbid
Home-based Resistance Training for Adults With Severe Obesity
This study evaluates whether adding home-based resistance training to a multidisciplinary specialist weight management service can promote weight loss and improve physical function, strength, power and quality of life in adults…
- Trial name
- NCT03900962
- Testing
- Home-based resistance training, Walking intervention
- Volunteers
- 38 people
- Sponsor
- University of Hull
Diabetes Mellitus, Non-Insulin-Dependent
Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Non-severe Obesity With Type 2 Diabetes Mellitus
The effect of roux-en-Y gastric bypass(RYGB) on patients with type 2 diabetes mellitus(T2DM) and a body mass index(BMI)>35kg/m2 is clear.
- Trial name
- NCT02091323
- Testing
- gastric bypass surgery
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Morbid Obesity
OnQ Pain Pump Effectiveness in Post Operative Pain Control in Bariatric Patients
This study will assess the efficacy of OnQ pain catheters in pain reduction in the bariatric surgical population and seeks to identify if a quantifiable improved post-operative course occurs in patients receiving a catheter…
- Trial name
- NCT03159130
- Where
- United States
- Sponsor
- William Beaumont Army Medical Center
Clinically Severe Obesity
Very Long Term Results After Laparoscopic Retrocolic Antegastric Gastric Bypass
The main aim of this study is to analyze and report the very long-term outcomes after primary laparoscopic proximal Roux-en-Y gastric bypass surgery for clinically severe obesity.
- Trial name
- >10yrsRYGB (NCT01040507)
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- University of California, San Francisco
Intubation;Difficult, Obesity, Morbid
Pre-Operative Airway Assessment of Patients With Morbid Obesity
Backround:The incidence of difficulty in laryngoscopy and endotracheal intubation is more common in obese patients. There are conflicting data on factors predicting difficult intubation.
- Trial name
- NCT04542187
- Where
- Turkey (Türkiye)
- Volunteers
- 121 people
- Sponsor
- Bagcilar Training and Research Hospital
Coronavirus Infection, Diabetes Mellitus, Type 2
Canakinumab in Patients With COVID-19 and Type 2 Diabetes
The purpose of this study is to evaluate whether Canakinumab has beneficial effects on patients with Type 2 diabetes mellitus and coronavirus disease 19 (COVID19).
- Trial name
- CanCovDia (NCT04510493)
- Testing
- Canakinumab
- Where
- 9 sites in Switzerland
- Volunteers
- 116 people
- Sponsor
- University Hospital, Basel, Switzerland