Clinical trials: Severe Obesity
Clinically Severe Obesity, Metabolic Complications After Jejunoileal Bypass
Laparoscopic Revision of Jejunoileal Bypass to Gastric Bypass
This study objectives are the following. To describe the updated clinical presentation, indications, and multidisciplinary medical management of patients with a failed and/or complicated jejunoileal bypass (JIB).
- Conditions
- Clinically Severe Obesity, Metabolic Complications After Jejunoileal Bypass, Nutritional Complications After Jejunoileal Bypass, Obesity Recidivism
- Trial name
- JIB-to-RYGB (NCT01040533)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Francisco
Morbid Obesity, Non Alcoholic Steatohepatitis
Non Invasive Measurements of Fibrosis, Inflammation and Steatohepatitis in Morbidly Obese Patients
Abstract: Fatty liver most frequently corresponds to a fat overload of the liver. It is usually classified as alcoholic steatosis or non-alcoholic steatosis.
- Trial name
- FIRM (NCT01695083)
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Diabetes
Epigenetic Mechanisms and Severe Obesity (Biological Tissue Collection)
The purpose of this study was to evaluate the role of vitamin status and epigenetic mechanisms on severe obesity related-complications.
- Conditions
- Obesity, Diabetes, Metabolic Diseases, Non-alcoholic Fatty Liver Disease
- Trial name
- OBESEPI (NCT02663388)
- Testing
- gastric bypass, sleeve, gastric banding
- Where
- France
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Lorraine
Morbid Obesity
Study to Determine Effective Dosing of Fondaparinux in Obese Persons
This is a prospective open-label study comparing two dosing regimens of fondaparinux, which is used to prevent deep vein thrombosis, in morbidly obese volunteers.
- Trial name
- NCT00346879
- Testing
- fondaparinux
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Morbid Obesity Requiring Bariatric Surgery
Relationship Between Serum Resistin Levels and Reduction in Visceral Fat in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity
This study aims to investigate whether a specific protein in the blood, called resistin, can help doctors predict how much dangerous internal fat a patient will lose following weight loss surgery.
- Trial name
- NCT07564986
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sercan YUKSEL, MD
Severe Obesity, Renal Failure
Obesity Surgery and Kidney Transplant for Patients With Obesity and Renal Failure
Gastric Bypass followed by renal transplantation is superior to medical management followed by renal transplant for patients with severe obesity and renal failure.
- Trial name
- NCT02128802
- Testing
- Gastric Bypass, Weight Loss Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Morbid, Gastroesophageal Reflux (GERD)
AJYR+GV vs RYGB for GERD
This study focuses on gastroesophageal reflux disease (GERD), a condition in which stomach acid flows back into the esophagus (the tube that carries food from the mouth to the stomach), causing heartburn and other symptoms.
- Trial name
- NCT07768202
- Testing
- sleeve gastrectomy with Roux-en-Y antrojejunal anastomosis, AJYR+SG, Roux-en-Y gastric bypass, RYGB
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Victor Dib Institute
Obesity
Diastolic Dysfunction During Conservative Lifestyle Treatment
The Purpose of this study is to 1) investigate prevalence of diastolic dysfunction in patients with morbid obesity attending a conservative lifestyle change program, 2) investigate effects on cardiac function, cardiorespiratory…
- Trial name
- NCT02826122
- Testing
- Pai APP, FitBit APP
- Where
- Norway
- Volunteers
- 57 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity, Obesity
Fondaparinux Population Pharmacokinetic to Morbid Obese Patients in Post-operatory Bariatric Surgery
After bariatric surgery , thromboembolics complications are major cause of mortality. However, in obese patients, thromboprophylaxia is a controversy.
- Conditions
- Morbid Obesity, Obesity, Surgery
- Trial name
- NCT01064596
- Testing
- blood samples
- Where
- 3 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Obesity, Morbid, Drug Use
Evaluation of the Implementation of Drug Prescription Recommendations Using Clinical Decision Support in Patients With Severe Obesity: Retrospective Study
No drug prescription guidelines for severe obesity (BMI>35 kg/m2) are available, leading to non-standardized and / or potentially inappropriate drug management.
- Trial name
- RECOB-MED (NCT06517303)
- Where
- 2 sites in France
- Volunteers
- 1,050 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 2, Bariatric Surgery Candidate
Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery
Bariatric operations such as the gastric bypass procedure provide a unique in vivo model of improvement of pathological beta cell function.
- Trial name
- NCT01271062
- Testing
- gastric bypass surgery, abdominal surgery, very low caloric diet
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 55 people
- Sponsor
- Cantonal Hospital of St. Gallen
Influenza, Obesity
Effectiveness and Tolerability of Influenza Vaccine in Patients at Risk for Severe and Complicated Influenza
The aim of the study is to evaluate simultaneously the immunological and clinical efficacy and tolerability of an influenza vaccine, inactivated, quadrivalent, with cleaved virus, in patients at risk for severe and complicated…
- Conditions
- Influenza, Obesity, Pregnancy; Infection, Elderly Infection
- Trial name
- NCT06286488
- Testing
- Vaxigrip
- Where
- Poland
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Psoriasis, Metabolic Syndrome
Comparison of Secukinumab 300 mg Combined With a Lifestyle Intervention to Secukinumab Alone for the Treatment of Moderate to Severe Psoriasis Patients With Concomitant Metabolic Syndrome
This study was a randomized, open-label, parallel-group, active comparator controlled study with two treatment arms designed to answer the question whether the combination of Secukinumab with lifestyle intervention could…
- Trial name
- METABOLYX (NCT03440736)
- Testing
- Secukinumab, Life-style intervention
- Where
- 75 sites in Germany
- Volunteers
- 781 people
- Sponsor
- Novartis Pharmaceuticals
Morbid Obesity, Exercise
Semi-supervised Exercise Program Before Bariatric Surgery
Background: Patients awaiting bariatric surgery, apart from suffering higher BMI, show a large number of comorbidities and a low physical fitness.
- Conditions
- Morbid Obesity, Exercise, Bariatric Surgery
- Trial name
- NCT03975244
- Testing
- Exercise program
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Cardiovascular Disease, High Cardiovascular Risk
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.
- Conditions
- Cardiovascular Disease, High Cardiovascular Risk, Obesity, Overweight
- Trial name
- CAMELLIA-TIMI (NCT02019264)
- Testing
- Lorcaserin hydrochloride
- Where
- 499 sites in United States, Australia and 6 more
- Volunteers
- 14,673 people
- Sponsor
- Eisai Inc.
Morbid Obesity
Gut Hormones After Roux-en-Y Gastric Bypass (RYGBP) Plus Gastric Fundus Resection
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is considered a combination of restriction-malabsorption procedure and one of the most common operative procedures implemented.
- Trial name
- NCT01341028
- Testing
- Roux-en-Y gastric bypass (LRYGBP), LRYGBP+gastric fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Morbid Obesity
Resolution of Comorbidities & Safety and Efficacy of Greater Curvature Plication in Obese Patients
The purpose of this study is to find out more about the safety and effectiveness of the Laparoscopic Greater Curvature Plication (LGCP) procedure in patients with obesity and related problems such as diabetes, hypertension, high…
- Trial name
- NCT02315105
- Testing
- Laparoscopic Greater Curvature Plication
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Singh, Kuldeep, M.D., P.A.
Morbid Obesity
Clinical and Economic Outcomes in Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass Surgery
Study objectives: 1. generate local clinical, health-related quality-of-life and health economic data to evaluate the benefits of two types of minimally invasive weight-loss surgery 2.
- Trial name
- OPTIMIZE (NCT01754194)
- Testing
- Gastric Sleeve Resection, Roux-en-Y Gastric Bypass
- Where
- 18 sites in Germany
- Volunteers
- 293 people
- Sponsor
- Medtronic - MITG
Obesity
Monitoring Patients With Severe Obesity Treated With Wegovy® Using Connected Device: Real-world Data
This study involves collecting real-world data on body weight, body composition, cardiovascular parameters, and neurovegetative parameters using a connected scale in patients with severe obesity treated with Wegovy®.
- Trial name
- TELE-SEMA (NCT06426446)
- Testing
- Withings Body Comp Pro
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity
Gastric Recalibration After Endoscopic Sleeve Gastroplasty
Endoscopic sleeve gastroplasty (ESG) is a technique used for bariatric surgery, with results comparable to conventional surgery, in order to treat morbid obesity.
- Trial name
- ESG-IRM (NCT04945473)
- Testing
- Endoscopic placement of additional sutures
- Where
- France
- Volunteers
- 100 people
- Sponsor
- IHU Strasbourg