Clinical trials: Severe Obesity
Severe Obesity
Comorbidity After Gastric Bypass
To evaluate effect on comorbid disease and weight loss in the long-term (>five years) after Roux-en-Y gastric bypass (RYGB) surgery for severe obesity.
- Trial name
- NCT02710786
- Testing
- Gastric bypass
- Where
- Sweden
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
Obesity & Overweight, Hair Loss
Scalp Hair Metabolomics in Severe Obesity
The purpose of this research study is to investigate how body weight and weight-loss surgery affect the natural chemicals found in scalp hair over time.
- Conditions
- Obesity & Overweight, Hair Loss, Metabolomics, Bariatric Surgery
- Trial name
- NCT07368842
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Morbid Obesity, Bariatric Surgery
Randomized Trial of Preoperative Diets Before Bariatric Surgery
Randomized clinical trial of two preoperative diets before bariatric surgery (gastric bypass)comparing standard diet and Prodimed (VLCD) in 100 morbidly obese patients selected for a gastric bypass procedure
- Conditions
- Morbid Obesity, Bariatric Surgery, Gastric Bypass
- Trial name
- NCT01652105
- Testing
- Standard diet versus standard VLCD (Prodimed)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Lievensberg Ziekenhuis
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-NPAP)
The objective of this clinical trial is to evaluate the efficacy of investigational drug UBT251 in the treatment of moderate-to-severe obstructive sleep apnea (OSA) with obesity, as well as to assess its safety.
- Trial name
- UNISHAPE-OSA-1 (NCT07767942)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Ulcerative Colitis, Obesity or Overweight
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disappearance of UC symptoms, and…
- Trial name
- COMMIT-UC (NCT06937086)
- Testing
- Mirikizumab, Tirzepatide
- Where
- 186 sites in United States, Austria and 21 more
- Volunteers
- 350 people
- Sponsor
- Eli Lilly and Company
Morbid Obesity, Metabolically Healthy Obesity
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Obesity
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with morbid obesity, metabolically healthy obesity and from healthy volunteers.
- Trial name
- BIOMIS-Endo (NCT04698135)
- Testing
- Biological samples collection, Questionnaire, Medical/laboratory examinations
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Obesity, Metabolic Syndrome
Prospective Cohort Study of the Effect of Bariatric/Metabolic Surgery on Morbid Obesity Patients With Metabolic Syndrome
The purpose of this study is to determine the change in kidney function and blood pressure after gastric bypass versus conventional medical therapy in morbid obesity.
- Trial name
- NCT02271568
- Testing
- Bariatric surgery, Intensive medical therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Hanyang University
Severe Obesity
Effect of Nutritional Intervention and Olive Oil in Severe Obesity
Obesity is a worldwide epidemic with increasing prevalence, specially severe obesity (Body Mass Index (BMI) ≥ 35 kg/m2). It is a multifactorial disease that involves genetic and environmental factors that lead to increased…
- Trial name
- NCT02463435
- Testing
- Nutritional intervention, Nutritional intervention plus olive oil, Olive oil
- Where
- Brazil
- Volunteers
- 229 people
- Sponsor
- Universidade Federal de Goias
Obstructive Sleep Apnea
Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
The purpose of this study is to test the effectiveness of two different weight loss diets on obstructive sleep apnea (OSA) severity.
- Trial name
- NCT02251574
- Testing
- Low Calorie Diet, Very Low Calorie Diet, Standard Care
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Obesity
Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population.
MAIN OBJECTIVE To compare the effects of the placement of an adjustable gastric band with "conventional" treatment of obesity. SECONDARY OBJECTIVES Compare the effects of the placement of a gastric band with "conventional"…
- Trial name
- CHADO (NCT01700738)
- Testing
- gastric ring surgery, nutritional help
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Diabetes
Personalised Medicine for Morbid Obesity
The prevalence of morbid obesity (BMI > 40 kg/m2) is increasing rapidly in the UK, but the investigators lack a coherent strategy for detailed assessment and treatment of the individuals affected, who are at high risk of…
- Trial name
- NCT01365416
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Morbid Obesity
Energy Balance and Inflammation in Obese Adults Bariatric Surgery Follow-up
The prevalence of obesity is steadily growing in many parts of the world in order to reach epidemic proportions. Changes in signaling pathways state of hunger and satiety contribute to the increase in obesity and metabolic…
- Conditions
- Obesity, Morbid Obesity, Metabolic Syndrome, Inflammation
- Trial name
- NCT02101814
- Testing
- Roux-en-Y gastric bypass (bariatric surgery)
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Federal University of São Paulo
Obesity, Morbid Obesity
Safety and Efficacy of Lean Body Weight-based IV Heparin Dosing in Obese/Morbidly Obese Patients
Standard weight-based IV heparin for normal weight patients is based on actual body weight (ABW). However, no well-defined guidelines have been established for patients considered to be obese or morbidly obese.
- Conditions
- Obesity, Morbid Obesity, Venous Thromboembolism, Atrial Fibrillation
- Trial name
- NCT01363193
- Testing
- Lean Body Weight-based heparin dose
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nazareth Hospital
Vitamin B12 Deficiency
Vitamin Deficiencies and Suppletion in Morbid Obesity
The purpose of this study is to evaluate the most effective treatment for patients who underwent a Roux-en-Y gastric bypass and developed postoperatively a vitamin B12 deficiency.
- Trial name
- NCT02270749
- Testing
- Hydroxocobalamin, FitForMe vitamin B12
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Rijnstate Hospital
Morbid Obesity, Bariatric Surgery Candidate
Intravenous Lidocaine in Bariatric Surgery.
Although peroperative intravenous lidocaine has been shown to be useful in early recovery after colorectal surgery, its beneficial effect on the specific population of obese patients scheduled for bariatric surgery remained…
- Trial name
- XYLOBAR (NCT03211455)
- Testing
- Lidocaine, isotonic saline
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Anomaly; Venous Return
Volume-challenge in Morbid Obesity
Preoperative venous return stability and euvolemia is essential in management of morbidly obese patients. Fluid therapy regimes for patients with high BMI, especially with focus on preoperative management, are rare and not in…
- Trial name
- NCT01748513
- Testing
- preoperative venous return optimizing
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Umeå University
Nebulization, Dexmedetomidine
Efficacy of Nebulized Dexmedetomidine on Blunting Hemodynamic Changes During Intubation and Pneumoperitoneum in Morbid Obese Patients During Laparoscopic Bariatric Surgery
This study aims to evaluate the effect of preoperative dexmedetomidine nebulization on blunting hemodynamic response for laryngoscope, intubation, pneumoperitoneum, and opioid consumption in morbidly obese patients undergoing…
- Conditions
- Nebulization, Dexmedetomidine, Hemodynamic Changes, Intubation
- Trial name
- NCT07054138
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Obesity Postoperative Pain, Obesity Morbid Obesity Postoperative Pain
Comparison of Paragastric Nerve Block and Erector Spinae Plane Block on Postoperative Pain After Sleeve Gastrectomy
Background: Laparoscopic sleeve gastrectomy is one of the most commonly performed bariatric procedures for the treatment of obesity.
- Trial name
- PGB-ESP (NCT07811206)
- Testing
- Paragastric Nerve Block (PGNB), ESPB, Active Comparator
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Atlas University
Obesity With Complications, Morbid Obesity
Bariatric Surgery and Reactive Hypoglycemia
Bariatric surgery has long been recognized as an effective treatment for grade 3 or grade 2 obesity associated with complications.
- Conditions
- Obesity With Complications, Morbid Obesity, Reactive Hypoglycemia, Bariatric Surgery
- Trial name
- NCT01581801
- Testing
- Gastric Bypass, Sleeve Gastrectomy
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Catholic University of the Sacred Heart
Morbid Obesity
Effect of Gastric Balloon in Morbid Obesity: Prospective Study
The aim of this study is to compare the efficacy of gastric balloon in weight reduction among two different categories of morbidly obese people.
- Trial name
- NCT02128165
- Testing
- BMI more than 45 BMI, BMI less than 45 BMI
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mansoura University