Clinical trials: Severe Obesity
Obesity, Overweight
Interactive Obesity Treatment Approach for Obesity Prevention in Adults With Early Serious Mental Illness: iOTA-SMI
Using a design-for-dissemination approach, this application proposes to use combined methods to adapt and pilot test an interactive obesity treatment approach (iOTA) for obesity prevention in early serious mental illness (eSMI)…
- Conditions
- Obesity, Overweight, Severe Mental Disorder
- Trial name
- iOTA-eSMI (NCT03980743)
- Testing
- iOTA text messaging intervention, Health Education text messaging intervention
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Washington University School of Medicine
Severe Obesity, Psychological Distress
Trajectories of Resilience and Bariatric Surgery Outcomes
A high prevalence of psychological trauma on one hand and of psychiatric disorders, such as depression, anxiety, suicide attempts, addictions, and eating disorders on the other hand, has been reported in patients with severe…
- Conditions
- Severe Obesity, Psychological Distress, Bariatric Surgery Candidate
- Trial name
- ECLAIRCIE (NCT05341414)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Protein Malnutrition, Vitamin Deficiency
Evaluation of Protein Intake and Micronutrient Supplementation After Bariatric Surgery
Obesity is a chronic disease in which accumulation of excess body fat can result in impaired health. In cases of severe obesity, weight loss surgery can be necessary as a treatment.
- Conditions
- Protein Malnutrition, Vitamin Deficiency, Mineral Deficiency, Trace Element Deficiency
- Trial name
- BOP (NCT04587076)
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- University Medicine Greifswald
Morbid Obesity
A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects
This study will determine how morbid obesity affects the distribution and metabolism of the drug propofol. The investigators hypothesize that propofol will be distributed and metabolized differently in morbidly obese subjects as…
- Trial name
- NCT01591148
- Testing
- propofol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Binge Eating Disorder
An Open-Label Trial of Memantine in the Treatment of Binge Eating Disorder
We hypothesize that memantine may be a safe and effective treatment for moderate to severe binge eating disorder associated with obesity.
- Trial name
- NCT00330655
- Testing
- memantine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mclean Hospital
Obesity, Severe, Pediatric Obesity
Weight Loss With Meal-Replacement Therapy in Teens
This study seeks to examine whether meal-replacement therapy is able to enhance weight loss among teens with severe obesity. In addition, we are also interested in examining the degree of weight loss needed to improve important…
- Trial name
- NCT03137433
- Testing
- Meal-replacement Therapy
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Morbid Obesity
Chronobiological Determinants of Gut Microbiome
The aim of this study is to examine how the number of daily eating occasions and the timing of energy intake influence gut microbiome composition in both morbidly obese and non-obese individuals.
- Trial name
- ChronoNutr (NCT07303036)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Obesity
Vitamin D Intervention in Young Adults With Severe Childhood-onset Obesity
Obesity is associated with lower total serum 25-hydroxycholecalciferol (S-25OHD) concentration. However, the impact of obesity on free S-25OHD is inadequately studied. A direct assay for free 25OHD was introduced recently.
- Trial name
- NCT02549326
- Testing
- vitamin D
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Obesity, Morbid Obesity
The Effect of Cognitive Function Level in Morbidly Obese Patients
Obesity is a disease caused by many factors, such as lifestyle, eating habits, lack of physical activity, hormonal and genetic influences. These different factors make treatment planning difficult.
- Trial name
- NCT07032415
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Kocaeli City Hospital
Morbid Obesity, Bariatric Surgery Candidate
EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
The risk of complications associated with airway management in obese patients is significant. The results of pre-oxygenation allow a prolonged non-hypoxic apnea time for the clinician.
- Trial name
- EPO2-PV (NCT02121808)
- Testing
- NIPPV, Tidal volume
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity, Severe Obesity
Prospective Study of an Explainable AI Tool to Support Biliopancreatic Limb Selection in One-Anastomosis Gastric Bypass
This prospective observational cohort study will develop and externally validate a human-supervised, explainable artificial-intelligence decision-support model for analysing factors associated with biliopancreatic limb length…
- Conditions
- Obesity, Severe Obesity, Metabolic Disease
- Trial name
- JI-AI-OAGB (NCT07818317)
- Testing
- One-anastomosis gastric bypass with observed biliopancreatic limb length
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Type 2 Diabetes, Morbid Obesity
Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study
Glycaemia, insulin secretion and action in morbidly obes subjects with type 2 diabetes after sleeve gastrectomy ond Roux-en-Y gastric bypass: A randomised single centre study.
- Trial name
- OSEBERG (NCT01778738)
- Testing
- Bariatric surgery, either gastric bypass surgery or sleeve gastrectomy, Sleeve gastrecomy, Bastric bypass
- Where
- Norway
- Volunteers
- 125 people
- Sponsor
- Sykehuset i Vestfold HF
Remimazolam, Desflurane
Remimazolam vs Propofol as an Induction Agent for Morbid Obesity Patients
It is known that morbidly obese patients are often accompanied by cardiovascular complications such as hypertension, cardiac hypertrophy, and diastolic dysfunction, and are known to increase the risk of hypotension during…
- Conditions
- Remimazolam, Desflurane, Morbid Obesity, Sleeve Gastrectomy
- Trial name
- NCT05856617
- Testing
- Remimazolam besylate
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Seoul National University Bundang Hospital
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Morbid Obesity
Does Body Mass Index Impact the Outcome of Dural Puncture Epidural in Parturients Undergoing Normal Vaginal Delivery
Recently, the dural puncture epidural (DPE) technique has emerged as a novel method of labor analgesia. The DPE technique is a modification of the combined spinal epidural (CSE) technique, where a dural perforation is created…
- Trial name
- NCT04963452
- Testing
- Dural puncture epidural
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Morbid Obesity
Taste Perception Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery, gastric bypass lap banding, and sleeve gastrectomy. The surgery is not part of the clinical trial.
- Trial name
- RBtaste (NCT01536197)
- Testing
- Gastric bypass, Gastric banding, Sleeve gastrectomy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Polycystic Ovary Syndrome, Severe Obesity
Effect of Metabolic Surgery on Live Birth Rate of Offspring in Obesity Polycystic Ovarian Syndrome Patients
This is a experimental study, which subjects are obese PCOS patients requiring LSG surgery. Aim to investigate the effects of LSG surgery in PCOS patients whether increases the live birth rate of the offspring.
- Conditions
- Polycystic Ovary Syndrome, Severe Obesity, Laparoscopic Sleeve Gastrectomy
- Trial name
- NCT04151459
- Testing
- Metformin
- Where
- China
- Volunteers
- 18 people
- Sponsor
- RenJi Hospital
Coronary Heart Disease, Stroke
Hamburg City Health Study - a German Cohort Study
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several risk and prognostic factors in major…
- Conditions
- Coronary Heart Disease, Stroke, Dementia, Cancer
- Trial name
- HCHS (NCT03934957)
- Where
- Germany
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Psoriasis, Plaque Psoriasis
Metformin Combined With Secukinumab for Moderate-to-Severe Plaque Psoriasis in Overweight or Obese Chinese Patients
This is a randomized, double-blind, placebo-controlled, multicenter clinical trial conducted in China. The study aims to evaluate the efficacy and safety of metformin combined with secukinumab in the treatment of…
- Conditions
- Psoriasis, Plaque Psoriasis, Moderate-to-severe Plaque Psoriasis, Overweight , Obesity
- Trial name
- NCT07485764
- Testing
- Secukinumab 300mg s.c., Metformin
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Obesity, Morbid Obesity
Effects of RM-493 on Energy Expenditure in Obese Individuals
Background: RM-493 is a drug that stimulates parts of the brain that control eating and metabolism. It has helped to reduce body weight and improve insulin sensitivity in lab tests.
- Trial name
- NCT01867437
- Testing
- RM-493
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Rhythm Pharmaceuticals, Inc.