Clinical trials: Severe Obesity
Obesity
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss…
- Trial name
- LightWAY (NCT06321458)
- Testing
- Intensive weight loss intervention, Usual care
- Where
- 14 sites in Denmark, United Kingdom
- Volunteers
- 605 people
- Sponsor
- Carsten Dirksen
Severe Obesity
Effect of Nutritional Intervention and Olive Oil in Severe Obesity
Obesity is a worldwide epidemic with increasing prevalence, specially severe obesity (Body Mass Index (BMI) ≥ 35 kg/m2). It is a multifactorial disease that involves genetic and environmental factors that lead to increased…
- Trial name
- NCT02463435
- Testing
- Nutritional intervention, Nutritional intervention plus olive oil, Olive oil
- Where
- Brazil
- Volunteers
- 229 people
- Sponsor
- Universidade Federal de Goias
Obesity, Insulin Resistance
Insulin Resistance in Severely Obese Patients
This study aims to understand the biological processes that link obesity to diseases including insulin resistance and diabetes. Our approach involves studying the health of patient undergoing weight loss either via weight…
- Conditions
- Obesity, Insulin Resistance, Diabetes
- Trial name
- NCT00275223
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Morbid
Intragastric Injections of Botox for the Treatment of Obesity
One possible angle for treating obesity could be slowing down the gastric emptying time. By prolonging the gastric emptying time, the person would ideally experience increased sensation of satiety, and in the long run reduce food…
- Trial name
- NCT02035397
- Testing
- Botulinum Toxin Type A, Saline solution
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity
Comparison of Laparoscopic Sleeve Gastrectomy and Roux-Y-gastric Bypass in the Treatment of Morbid Obesity
The laparoscopic sleeve-gastrectomy (SG) compared to laparoscopic proximal Roux-Y-gastric bypass (PGB) is as successful in the treatment of morbid obesity in the majority of patients.
- Trial name
- NCT00356213
- Testing
- sleeve gastrectomy, Roux-Y-gastric bypass
- Volunteers
- 217 people
- Sponsor
- University Hospital, Basel, Switzerland
Morbid Obesity
Weight Loss & Comorbidity Resolution With LAGB Alone vs. LAGB With Gastric Plication
The purpose of this research study is to evaluate whether combining laparoscopic adjustable gastric band (AKA: lap-band surgery, LAGB) and laparoscopic gastric plication (making tucks in the large curve of the stomach with…
- Trial name
- NCT01703546
- Testing
- LAGB & LGCP
- Where
- 2 sites in United States
- Volunteers
- 420 people
- Sponsor
- Northwell Health
Obesity, Diabetes
Residual Gastric Volume in Morbidly Obesa Diabetics. A Comparison of 3 Hour Versus Hour Fasting.
To reduce the risk of aspiration for elective procedures, residual gastric volumes (RGV) have traditionally been minimized with overnight fasting.
- Conditions
- Obesity, Diabetes, Fasting
- Trial name
- NCT02114008
- Testing
- Endoscopic examinations
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- Cuiaba University
Morbid Obesity
Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass
The goal of this observational study is to learn whether routine stool tests can detect changes in gut function 6 months after two common types of weight loss surgery: sleeve gastrectomy and gastric bypass (including mini gastric…
- Trial name
- NCT07461610
- Testing
- Laparoscopic Sleeve Gastrectomy, Mini Gastric Bypass, Roux-en-Y Gastric Bypass
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Atelectasis, Pulmonary Infection
Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
The effect of biphasic positive airway pressure (Bi-PAP) at individualized pressures on the postoperative pulmonary recovery of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) and possible placebo…
- Conditions
- Atelectasis, Pulmonary Infection, Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Disease
- Trial name
- NCT03438383
- Testing
- Bi-PAP
- Volunteers
- 48 people
- Sponsor
- Evangelismos Hospital
Morbid Obesity
Conventional Laparoscopic Sleeve Gastrectomy Versus Endograb-assisted Single-port Sleeve Gastrectomy
Bariatric surgery has been established as the best treatment for morbid obesity, compared with diet or medical treatment. Laparoscopic approach have improved the results of this surgery in terms of postoperative pain, reduction…
- Trial name
- GTLEND (NCT02023294)
- Testing
- Convetional laparoscopic Sleeve Gastrectomy, SILS Sleeve gastrectomy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Morbid Obesity, Cesarean Section Complications
Anesthetic and Obstetric Outcomes in Morbidly Obese Pregnancy and Cesarean Delivery
Given that morbid obesity has been strongly associated with obstetric, neonatal and anesthetic complications, and that scarce reports have evaluated anesthetic and obstetric outcomes after cesarean delivery in morbidly obese…
- Conditions
- Morbid Obesity, Cesarean Section Complications, Pregnancy Related
- Trial name
- NCT03590951
- Testing
- Retrospective chart review
- Where
- United States
- Volunteers
- 771 people
- Sponsor
- Augusta University
Type 2 Diabetes, Morbid Obesity
Diabetes Remission After RYGBP and RYGBP With Fundus Resection
The goal of this randomized clinical trial is to evaluate glycemic control in patients with morbid obesity and type 2 diabetes after Roux-en-Y gastric bypass (RYGBP) and RYGBP with fundus resection.
- Conditions
- Type 2 Diabetes, Morbid Obesity, Bariatric Surgery
- Trial name
- NCT05854875
- Testing
- Laparoscopic Roux en Y gastric bypass, Laparoscopic Roux en Y gastric bypass with fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Morbid Obesity, Metabolic Syndrome
Impact GLP-1 Agonists Following Bariatric
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic…
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension
- Trial name
- NCT06132477
- Testing
- GLP-1 receptor agonist
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Missouri-Columbia
Obesity
Exercise Training and Fitness in Severe Obesity
Obesity is commonly associated with insulin resistance and hyperinsulinemia, which seem to be linked with an impaired ability to oxidize lipids, particularly in class III obese individuals [Body Mass Index (BMI): > 40 kg*m-2].
- Trial name
- INTFMOBE (NCT02254200)
- Testing
- Fatmax group, HIIT group
- Where
- Italy
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Weight Loss, Metabolism and Nutrition Disorder
The Effect of High vs. Moderate Protein Consumption on Human Health
The study will be conducted as a parallel randomized controlled intervention trial, initiated by eight weeks rapid weight loss with one of two VLCDs, one week of reintroducing regular foods, and 12 weeks with one of two different…
- Conditions
- Weight Loss, Metabolism and Nutrition Disorder, Obesity
- Trial name
- BEEF (NCT04156165)
- Testing
- VLCD-Active, Maintenance-Active, VLCD-Control
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Morbid Obesity
Extending and Banding the Roux-en-Y Gastric Bypass
The Roux-en-Y gastric bypass (RYGB) has proven to be an effective treatment for morbid obesity by reducing weight and comorbidities. Extending the pouch may improve weightloss without the increase of complications.
- Trial name
- UPGRADE (NCT05357807)
- Testing
- Standard RYGB, Extended Pouch RYGB, Banded extended pouch RYGB
- Where
- 3 sites in Netherlands
- Volunteers
- 375 people
- Sponsor
- Rijnstate Hospital
Depressive Disorder, Major, Obesity
Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression
Major depressive disorder (MDD) and obesity are major contributors to impaired health worldwide. Statins are among the most prescribed medications with well-established safety and efficacy.
- Trial name
- SIMCODE (NCT04301271)
- Testing
- Simvastatin 40mg
- Where
- 9 sites in Germany
- Volunteers
- 161 people
- Sponsor
- Charite University, Berlin, Germany
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-PAP)
UBT251 will be compared with placebo (an inactive substance identical in appearance) to evaluate its therapeutic effect in participants with moderate-to-severe obstructive sleep apnea maintained on positive airway pressure…
- Trial name
- UNISHAPE-OSA-2 (NCT07806851)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Exercise
Effect of Exercise Intervention on Body Composition and Quality of Life in Post-bariatric Surgery Patients
This study will investigate the effectiveness of a rehabilitation program in improving body composition, and quality of life in patients with bariatric surgery in Taiwan. Hypothesis: 1.
- Trial name
- NCT04151836
- Testing
- Exercise education
- Where
- Taiwan
- Volunteers
- 85 people
- Sponsor
- Chang Gung Memorial Hospital
Morbid Obesity, Vertical Sleeve Gastrectomy
Metabolic Syndrome, Bile Acids, Hepatocellular Carcinoma and Cholangiocarcinoma
Increasing rates of highly malignant hepatocellular carcinoma (HCC) and biliary tract cancers (GBTC) observed in Western populations may be related to obesogenic lifestyle factors and their metabolic consequences, such as…
- Conditions
- Morbid Obesity, Vertical Sleeve Gastrectomy, Metabolic Syndrome, Hepatocellular Carcinoma
- Trial name
- METSLIVER (NCT02730611)
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris