Clinical trials: Severe Obesity
Obesity, Severe Obesity
Energy Expenditure From ECAL Indirect Calorimeter in a Multicomponent Weight Management Service
Whether greater weight loss is as a result of a smaller reduction in energy expenditure with caloric restriction is not known. Resting energy expenditure and 24-hour energy expenditure vary substantially between individuals.
- Conditions
- Obesity, Severe Obesity, Sleep Apnoea
- Trial name
- ECAL (NCT03638895)
- Testing
- ECAL Indirect Calorimeter, Diet, exercise & behaviour modification therapy
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Adiposity, Morbid
Endoscopic Gastric Mucosal Ablation (GMA) of Class III Obesity
This study is intended to investigate safety and feasibility of a new weight loss technique called Gastric Mucosal Ablation (GMA) that does not require surgery, but can be achieved using an endoscopic procedure.
- Conditions
- Adiposity, Morbid, Obesity
- Trial name
- NCT05574777
- Testing
- Hybrid Argonplasma coagulation (HAPC)
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- Erbe Elektromedizin GmbH
Obesity, Mental Disorders, Severe
Adapted ACHIEVE Curriculum for Community Mental Health Settings
In light of the obesity epidemic in persons with serious mental illness (SMI), there is an urgent need to scale-up behavioral interventions that have demonstrated efficacy in the clinical trial setting such as the intervention in…
- Trial name
- NCT03999892
- Testing
- ACHIEVE
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Johns Hopkins University
Weight Loss, Metabolism and Nutrition Disorder
The Effect of High vs. Moderate Protein Consumption on Human Health
The study will be conducted as a parallel randomized controlled intervention trial, initiated by eight weeks rapid weight loss with one of two VLCDs, one week of reintroducing regular foods, and 12 weeks with one of two different…
- Conditions
- Weight Loss, Metabolism and Nutrition Disorder, Obesity
- Trial name
- BEEF (NCT04156165)
- Testing
- VLCD-Active, Maintenance-Active, VLCD-Control
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Morbid Obesity, Bariatric Surgery Candidate
Physical Activity in Bariatric Patients
The aim of the current study was to explore the effect of a 6-months motivational physical activity intervention (MPAI) on different psychosocial variables (e.g.
- Trial name
- NCT03666481
- Testing
- Motivational Physical Activity Intervention (MPAI)
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations
Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers
The purpose of this screening study is to identify people who have a rare genetic cause of obesity - specifically three genetic variants (a change in the DNA structure) of the POMC, PCSK1 and LepR genes that are currently known…
- Trial name
- NCT02849977
- Where
- 58 sites in United States, Canada and 5 more
- Volunteers
- 5,966 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Obesity
Pharmacokinetics of Dexmedetomidine in Morbid Obesity
Dexmedetomidine hydrochloride ,a relatively new drug in Chinais ,is a highly selective, potent a2-adrenoceptor agonist with significant analgesic, sedative and anxiolytic effects.
- Trial name
- NCT01864187
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Mental Illness Persistent, Chronic Disease
Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border
This study evaluated whether patients with severe and persistent mental illness (SPMI) who received coordinated co-located behavioral health and primary care services were more likely to improve health outcomes after 12 months…
- Conditions
- Mental Illness Persistent, Chronic Disease, Hypertension, Diabetes
- Trial name
- NCT03881657
- Testing
- Reverse Colocated Integrated Care, Usual Care
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Health Resources in Action, Inc.
Morbid Obesity
Preoperative PPI in Sleeve Gastrectomy
he purpose of this study is to study the effect of preoperative PPI in the early outcome of sleeve gastrectomy
- Trial name
- NCT03305432
- Testing
- sleeve + preoperative PPI
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Minia University
Morbid Obesity, Cesarean Section Complications
Anesthetic and Obstetric Outcomes in Morbidly Obese Pregnancy and Cesarean Delivery
Given that morbid obesity has been strongly associated with obstetric, neonatal and anesthetic complications, and that scarce reports have evaluated anesthetic and obstetric outcomes after cesarean delivery in morbidly obese…
- Conditions
- Morbid Obesity, Cesarean Section Complications, Pregnancy Related
- Trial name
- NCT03590951
- Testing
- Retrospective chart review
- Where
- United States
- Volunteers
- 771 people
- Sponsor
- Augusta University
Morbid Obesity, Surgery
Oxygen Reserve Index: Utility as Early Warning for Desaturation in Morbidly Obese Patients
The Oxygen Reserve Index (ORi) is a reference that could help clinicians with their assessments of normoxic and hyperoxic states by scaling the measured absorption information between 0.00 and 1.00.
- Trial name
- NCT03021551
- Testing
- Rainbow sensor
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Masimo Corporation
Severe Obesity, Bariatric Surgery
Study on Impact of Lifestyle Change and Weight Loss Before Bariatric Surgery
The purpose of the trial is to determine whether a preoperative lifestyle intervention (targeting diet, exercise, and preparation for surgery) will favorably impact obesity-related parameters prior to bariatric surgery and…
- Trial name
- PREP (NCT00623792)
- Testing
- Preoperative lifestyle Intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duquesne University
Morbid Obesity
Pharmacokinetics of Acetaminophen in Morbidly Obese Patients
This study will investigate the pharmacokinetics of acetaminophen in morbidly obese patients versus normal weight patients. Specifically the different metabolic pathways of acetaminophen in morbidly obese adults will be…
- Trial name
- APAP (NCT01764555)
- Testing
- acetaminophen 2 g
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Morbid Obesity
CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug
Before and during bariatric surgery patients are given oral and i.v. midazolam, respectively and blood samples are drawn to establish midazolam time-concentration profiles.
- Trial name
- MEMO (NCT01519726)
- Testing
- Midazolam
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- St. Antonius Hospital
Obstructive Sleep Apnea, Obesity
Lifestyle Program for Obstructive Sleep Apnea With Severe Obesity
The purpose of this study is to develop a data driven system for persons with severe obesity sleep apnea that utilizes remote monitoring with health coaching to create behavior changes aimed at improving health and quality of…
- Trial name
- NCT05343000
- Testing
- Home-based pulmonary rehabilitation (PR) system
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Morbid Obesity
Sugammadex Dosage Based on Ideal Body Weight for Profound Rocuronium-induced Neuromuscular Blockade Reversal in Morbidly Obese Patients
This randomized double blind clinical trial focuses on patients with Body Masse Index ≥ 40 kg/m2, undergoing scheduled surgery. Neuromuscular transmission monitoring at the adductor is performed using.
- Trial name
- NCT02545595
- Testing
- Sugammadex 1 mg/kg, Sugammadex 2 mg/kg, Sugammadex 4 mg/kg
- Where
- France
- Sponsor
- Poitiers University Hospital
Severe Obesity
Resting Metabolic Rate is a Predictor of Weight Regain?
he increasing prevalence of obesity in developed countries has also reached Brazil in the last two decades. Conventional treatments are not efficient to sustained weight loss and in some cases, weight reduction in individuals…
- Trial name
- NCT04118582
- Testing
- Body composition and resting metabolic rate analisys
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Bariatric Surgery Candidate, Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting After Bariatric Surgery
Postoperative nausea and vomiting are common occurrences following bariatric surgery, occurring in up to 80% of patients and contributing to increased healthcare utilization and delays in discharge.
- Conditions
- Bariatric Surgery Candidate, Postoperative Nausea and Vomiting, Morbid Obesity
- Trial name
- NCT04644445
- Testing
- Bariatric Full Liquid Diet
- Where
- 2 sites in United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Obesity, Morbid Obesity
Monitoring Obese Patients : Impact on the Frequency of Monitoring Weight
The literature data show that long-term monitoring has an effect on weight loss, comorbidity and on improving the quality of life.
- Conditions
- Obesity, Morbid Obesity, Quality of Life
- Trial name
- SUIVIOBESITE (NCT02374866)
- Testing
- closer monitoring
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Limoges
Morbid Obesity
Laparoscopic Adjustable Gastric Banding as a Treatment for Morbid Obesity in Adolescents
The purpose of this study is to determine whether the LAP-BAND system is safe and effective in morbidly obese adolescents.
- Trial name
- NCT00592202
- Testing
- Placement of an adjustable gastric band
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Illinois Chicago