Clinical trials: Severe Obesity
Morbid Obesity Requiring Bariatric Surgery
Relationship Between Serum Apolipoprotein Levels and Weight Loss in Patients Undergoing Sleeve Gastrectomy for Morbid Obesity
The study looks at whether a specific protein in the blood, called apolipoprotein, can predict how much weight a person might lose after sleeve gastrectomy, a surgery for people with severe obesity.
- Trial name
- NCT07325916
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Yigit DUZKOYLU
Morbid Obesity
Investigations on the Influence of Bariatric Surgery on the Metabolism and Absorption of Atorvastatin
Altered bioavailability of drugs will potentially affect both drug efficacy as well as safety. In patients subjected to bariatric surgery due to morbid obesity the gastro intestinal tract is considerably reconstructed and a…
- Trial name
- NCT00331565
- Testing
- Bariatric surgery
- Where
- Norway
- Volunteers
- 36 people
- Sponsor
- University of Oslo School of Pharmacy
Asthma
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics
Asthmatics who are significantly overweight tend to have more severe symptoms, more flare ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics.
- Trial name
- GLITZ Asthma (NCT00634036)
- Testing
- pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fernando Holguin
Morbid Obesity, Anesthesia Awareness
Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients
Obesity is a chronic disease that affects quality and duration of life negatively. It's not clearly known the effects of low flow anesthesia on cerebral oxygenation with high-risk morbidly obese patients.
- Conditions
- Morbid Obesity, Anesthesia Awareness, Anesthesia Complication
- Trial name
- CerOxygen (NCT03438734)
- Testing
- Regional cerebral oxygen saturation, Bispectral Index (BIS)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Inonu University
Morbid Obesity, Atherosclerosis
Use of Flaxseed(Alpha Linolenic Acid) Powder in Morbidly Obese Patients With Systemic Inflammation
Preliminary studies have shown that flaxseed powder, rich in the omega-3 alpha-linolenic acid,is beneficial for the general inflammation present in morbidly obese subjects by decreasing elevated serum markers.As omega-3 fatty…
- Conditions
- Morbid Obesity, Atherosclerosis, Systemic Inflammation
- Trial name
- NCT00502021
- Testing
- Alpha-linolenic acid/ALA, Alpha linolenic acid/ALA
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea (OSA)
Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Receiving Positive Airway Pressure (PAP) Therapy
The study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial to evaluate the efficacy and safety of GZR18 injection in Chinese adult obese patients with moderate-to-severe…
- Trial name
- NCT07501832
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Lysosomal Acid Lipase Deficiency, Obesity
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
The very low carbohydrates diet (VLCKD) induces liver steatosis amelioration. Lysosomal acid lipase (LAL) deficiency plays a role in fats accumulation in liver. To date, no studies have assessed LAL activity in morbid obesity.
- Conditions
- Lysosomal Acid Lipase Deficiency, Obesity, Ketogenic Dieting, Ketosis
- Trial name
- NCT03564002
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Morbid Obesity, Obstructive Sleep Apnea
Effect of Endoscopic Gastric Balloon Insertion on Obstructive Sleep Apnea in Patients With Morbid Obesity
To investigate the effect of weight loss by gastric balloon insertion on parameters of obstructive sleep apnea.
- Trial name
- NCT00305032
- Testing
- gastric balloon insertion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Morbid Obesity
Laryngeal Mask in Morbid Obesity
Investigators study the performance of both masks, Proseal Laryngeal Mask Airway (PLMA) and I-gel, as temporary ventilatory supraglottic airway devices (SGDs) before tracheal intubation in morbidly obese patients.
- Trial name
- NCT04243564
- Testing
- Supraglottic device (SGD)
- Where
- Italy
- Sponsor
- University of Padova
Morbid Obesity
Comparison of Gastric Bypass and Sleeve Gastrectomy in Metabolic and Cardiovascular Indices
Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery.
- Trial name
- NCT03851874
- Testing
- Bariatric surgery
- Volunteers
- 28 people
- Sponsor
- National and Kapodistrian University of Athens
Morbid Obesity
A Study of Clinical Outcomes of the REALIZE Adjustable Gastric Band-C
The purpose of this study is to evaluate the results patients are obtaining with the Realize™ Adjustable Gastric Band-C during the first 24 months after surgery.
- Trial name
- NCT00999661
- Where
- 7 sites in United States
- Volunteers
- 231 people
- Sponsor
- Ethicon Endo-Surgery
Obesity, Morbid Obesity
Activity Level Monitoring Study
The purpose of this study is to 1) evaluate the relationship of physical activity to quality of life and psychological functioning among adults with severe obesity (BMI>40) and 2) evaluate the effects of activity monitoring on…
- Trial name
- ALMS (NCT05379088)
- Testing
- Phone/zoom calls
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Morbid Obesity
Study to Determine Effective Dosing of Fondaparinux in Obese Persons
This is a prospective open-label study comparing two dosing regimens of fondaparinux, which is used to prevent deep vein thrombosis, in morbidly obese volunteers.
- Trial name
- NCT00346879
- Testing
- fondaparinux
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Obesity, Morbid
Outpatient Bariatric Surgery
This study first presents the organizational path and the health interventions included in the care episode for outpatient bariatric surgery, as compared to the health interventions usually performed in the care episode for…
- Trial name
- Bariatric Ambu (NCT04423575)
- Testing
- Outpatient health care pathway
- Where
- France
- Volunteers
- 60 people
- Sponsor
- IHU Strasbourg
Severe Obesity, Diabetes Mellitus, Type 2
Diabetes Remission and Hypoabsorptive Bariatric Surgery
Bariatric surgery is the most effective treatment to achieve type 2 Diabetes Mellitus (DM) remission in patients with severe obesity.
- Conditions
- Severe Obesity, Diabetes Mellitus, Type 2, Bariatric Surgery Candidate
- Trial name
- DIABAR-3 (NCT06043245)
- Testing
- Duodenal Switch, SADI-S, Minigastric Bypass
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Universitari de Bellvitge
Pulmonary Atelectasis, Respiratory Tract Diseases
Use of Positive Pressure in Morbidly Obese Patients Undergoing Reduction Stomach Surgery
The aim of this study was to investigate the effects of using positive pressure in the preoperative, intraoperative and postoperative morbidly obese individuals undergoing gastroplasty.
- Conditions
- Pulmonary Atelectasis, Respiratory Tract Diseases, Pathological Conditions, Signs and Symptoms
- Trial name
- NCT01786681
- Testing
- Positive pressure
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Morbid Obesity
Gastric Procedures for Obesity
This is a prospective case series study; all morbidly obese patients that need surgical management in Royal Alexandra Hospital will be provided 3 surgical options: Laparoscopic Sleeve Gastrectomy (LSG), laparoscopic Roux-en-Y…
- Trial name
- NCT01026181
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Hypotension, Anomaly; Venous Return
Perioperative Fluid Management in Morbidly Obese Patients
In bariatric surgery functional and feasible non- or mini-invasive modalities for monitoring, and ideal/lean body weight estimates are addressed to meet up individual variability in hydration needs, and to avoid hyperhydration.
- Conditions
- Hypotension, Anomaly; Venous Return, Dehydration
- Trial name
- NCT01873183
- Testing
- Goal directed fluid therapy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Umeå University
Morbid Obesity
Sedation of Morbidly Obese for Balloon Insertion
This prospective study will assess the value of different supplements to orpofol bases anesthesia in morbidly obes e patients scheduled for balloon insertion.
- Trial name
- SedBaloon (NCT03747094)
- Testing
- Fentanyl, Ketamine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Obesity, Morbid, Obesity
Topiramate in Adolescents With Severe Obesity
The prevalence of severe pediatric obesity is on the rise and youth with this condition are at elevated risk for developing chronic diseases such as cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM).
- Conditions
- Obesity, Morbid, Obesity, Weight Loss
- Trial name
- NCT01859013
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Minnesota