Clinical trials: Severe Obesity
Obesity, Morbid
FAECAL MICROBIOTA TRANSPLANTATION IN OBESITY
40 patients meeting the criteria for obesity surgery are enrolled. Fecal microbiota transplantation (FMT) will be administered in gastroscopy 6 months before obesity surgery.
- Trial name
- NCT03391817
- Testing
- Fecal microbiota transplantation
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Hyperglycemia
The Association Between Peri-Operative Hyperglycemia and Major Morbidity and Mortality
Surgery induces a stress effect on the body partially through a catabolic energy state. In turn, glucose levels may rise to levels which have been associated with major morbidity (Golden, 1999) and mortality (Ouattara, 2005).
- Trial name
- NCT00487162
- Testing
- intensive glycemic control, conventional glycemic control
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Severe Obesity
Mazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe Obesity
The SMART study is a 96-week, multicenter, randomized, double-blind, placebo-controlled superiority clinical trial. A total of 256 severe obesity patients are randomized 1:1 to either receive the bariatric surgery plus GCG/GLP-1…
- Trial name
- SMART (NCT07135141)
- Testing
- Sleeve gastrectomy plus early mazdutide initiation
- Where
- 14 sites in China
- Volunteers
- 256 people
- Sponsor
- Beijing Friendship Hospital
Morbid Obesity
Bariatric Procedures and Changes in Incretins and Gastric Emptying
The study evaluates the gastric emptying by scintigraphy in patients that had bariatric surgery (RYGB of gastric sleeve) comparing patients with successful and unsuccessful weight loss and in patients before and after the…
- Trial name
- BIG (NCT02539641)
- Testing
- Gastric emptying scintigraphy, Determination of gut hormones
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Rijnstate Hospital
Morbid Obesity
Resolution of Comorbidities & Safety and Efficacy of Greater Curvature Plication in Obese Patients
The purpose of this study is to find out more about the safety and effectiveness of the Laparoscopic Greater Curvature Plication (LGCP) procedure in patients with obesity and related problems such as diabetes, hypertension, high…
- Trial name
- NCT02315105
- Testing
- Laparoscopic Greater Curvature Plication
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Singh, Kuldeep, M.D., P.A.
Morbid Obesity
Study to Determine Effective Dosing of Fondaparinux in Obese Persons
This is a prospective open-label study comparing two dosing regimens of fondaparinux, which is used to prevent deep vein thrombosis, in morbidly obese volunteers.
- Trial name
- NCT00346879
- Testing
- fondaparinux
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Patients After Metabolic-bariatric Surgery, Obesity, Morbid
Adipositas Care & Health Therapy
ACHT - Adipositas Care and Health Therapy - is a structured, digitally-supported, cross-sectoral and close to home program developed for the postoperative care of patients following obesity surgery.
- Trial name
- ACHT (NCT04768127)
- Testing
- early aftercare, mid-term to late aftercare
- Where
- 7 sites in Germany
- Volunteers
- 586 people
- Sponsor
- Wuerzburg University Hospital
Morbid Obesity, Overweight
Pharmacokinetics in Morbid Obesity After Bariatric Surgery
Morbid obesity (MO) is associated with several disorders such as hypertension, type 2 diabetes, dyslipemia and degenerative arthropathy that require pharmacological treatment.
- Trial name
- FAROBE/1 (NCT01086722)
- Testing
- "karolinska cocktail"
- Where
- 2 sites in Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fundacion IMIM
Severe Mental Disorder, Metabolic Complication
Effectiveness of a Pragmatic, Metabolic Care Clinic for Patients With Severe Mental Illness - The Meta Care Clinic
This study will examine the effectiveness of a Pragmatic, Metabolic Care Clinic for Patients With Severe Mental Illness
- Conditions
- Severe Mental Disorder, Metabolic Complication, Side-Effect;Medication, Schizophrenia Spectrum and Other Psychotic Disorders
- Trial name
- NCT06624462
- Testing
- Treatment in the Meta Care Clinic, Standard care with general practitioner and/or outpatient clinics
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Bjorn H. Ebdrup
Obesity, Weight Loss
Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
Obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05055154
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 26 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Obesity
Comparison of a Technology-based System and an In-person Behavioral Weight Loss Intervention in the Severely Obese
The purpose of this study is to examine the effect of an enhanced technology-based system, that involves a wearable device to measure calories burned combined with a website, in comparison to previous versions of similar…
- Trial name
- NCT01537796
- Testing
- In-Person weight loss, FIT weight loss, FIT-BT weight loss
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity, Severe, Surgery
Connected Scales to Optimize the Maintenance of Weight Lost After Bariatric Surgery and Limit Failures and Reoperations
In this research, we hypothesize that post-operative monitoring implemented with a connected scale after the 1st year (weight nadir period) post obesity surgery (i.e.
- Trial name
- COMPA (NCT06133413)
- Testing
- Body Comp Pro connected scale (Withings manufacturer), Alert generation by remote plateform
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity
The Role of the Omentum in the Treatment of Morbid Obesity
The purpose of this research is to determine some of the reasons that blood sugar and insulin levels improve after bariatric surgery but before weight loss begins, as well as why people respond differently to weight loss surgery.
- Trial name
- NCT00212160
- Testing
- omentectomy
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Morbid Obesity, Obstructive Sleep Apnea
Laparoscopic Adjustable Gastric Banding With Truncal Vagotomy
Laparoscopic Adjustable Gastric Banding (LAGB) is a gold standard in the surgical treatment of morbid obesity. We hypothesize that the addition of truncal vagotomy (cutting of nerves to the stomach) will produce greater weight…
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea, Hypertension, Urinary Incontinence
- Trial name
- NCT00329862
- Testing
- Laparoscopic Truncal Vagotomy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Central Carolina Surgery, PA
Obesity, Morbid
Biliary Limb as a Percentage From the Small Intestine Rather Than Fixed Length in Loop Bypass Surgery for Morbid Obesity
in all loop bypass bariatric procedure (mini gastric bypass \& single anastomosis sleeve jejunal bypass), biliary limb is fixed length. we do it as a percentage from total small intestine length rather than fixed length
- Trial name
- NCT04826055
- Testing
- biliary limb as fixed length, biliary limb as a percentage from small intestine length
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Minia University
Severe Obesity Scheduled for Bariatric Surgery
Cardiometabolic Risk Factor Management and Adherence to Antihypertensive Therapy in Patients With Severe Obesity Prior to Bariatric Surgery: a Prospective Longitudinal Cohort Study
Patients with severe obesity frequently exhibit elevated cardiovascular risk. Contributing factors could be inadequate recognition and subsequent management of cardiovascular risk factors, and non-adherence to cardiovascular…
- Trial name
- NCT07441304
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Universität des Saarlandes
Morbid Obesity, Insulin Resistance
Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery
The purpose of this research is to further study the effect weight loss after gastric bypass surgery has on the heart and blood pressure and on how the body uses or metabolizes the sugars, fats and proteins we eat.
- Conditions
- Morbid Obesity, Insulin Resistance, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT01007955
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Massachusetts, Worcester
Obesity and Overweight, Obese Adolescents
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3).
- Conditions
- Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
- Trial name
- MODERN (NCT06967389)
- Testing
- Ozempic®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Bauer
Morbid Obesity, Obstructive Sleep Apnea Syndrome
LAGB as a Treatment for Morbid Obesity in Adolescents
Laparoscopic adjustable gastric banding (LAGB) has been used worldwide to help selected morbidly obese adults to lose weight. The FDA has approved LAGB only for patients 18 years or older.
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea Syndrome, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01045499
- Testing
- Laparoscopic adjustable gastric banding (Allergan Lap Band)
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Jeffrey L Zitsman, MD
Morbid Obesity
Creating a Laparoscopic Banded Sleeve Gastrectomy
A Sleeve Gastrectomy (SG) is on the long term not always successful in every patient because weight regain can occur. An intervention to prevent weight regain in the future is to place a silicone band (non-adjustable) around the…
- Trial name
- RING (NCT04610099)
- Testing
- Banded Sleeve Gastrectomy, Standard SG
- Where
- 3 sites in Netherlands
- Volunteers
- 211 people
- Sponsor
- Rijnstate Hospital