Clinical trials: Severe Obesity
Dexmedetomidine, Fentanyl
Dexmedetomidine vs Fentanyl on Time to Extubation in Patients Undergoing Laparoscopic Sleeve Gastrectomy
This study aims to compare the efficacy of dexmedetomidine versus fentanyl during general anesthesia for patients with morbid obesity undergoing laparoscopic sleeve gastrectomy.
- Conditions
- Dexmedetomidine, Fentanyl, Time to Extubation, Morbid Obesity
- Trial name
- NCT06052111
- Testing
- Group F (fentanyl group), Group D (dexmedetomidine group)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Helwan University
Morbid Obesity
Bariatric Surgery and HDL-cholesterol
Objective: to assess the effect of gastric bypass on HDL-cholesterol concentration and its Apolipoprotein A4 content at 1 year following bariatric surgery in comparison with a hypocaloric diet.
- Trial name
- NCT01707771
- Testing
- Roux-en-Y gastric bypass, diet and lifestyle modifications
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Severe Obesity, Psychological Distress
Trajectories of Resilience and Bariatric Surgery Outcomes
A high prevalence of psychological trauma on one hand and of psychiatric disorders, such as depression, anxiety, suicide attempts, addictions, and eating disorders on the other hand, has been reported in patients with severe…
- Conditions
- Severe Obesity, Psychological Distress, Bariatric Surgery Candidate
- Trial name
- ECLAIRCIE (NCT05341414)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Obesity, Number of Steps Per Day < 7000
Study of Neuromuscular Electrical Stimulation to Increase Spontaneous Physical Activity in Obesity Patient
The study was designed to test the following hypotheses: Main Objective: To compare the level of spontaneous physical activity at 3 months after re-entrainment by multi-site electrical stimulation (m-ES), measured by actigraphy…
- Trial name
- STIMOBIII (NCT02210585)
- Testing
- Rehabilitation
- Where
- 3 sites in France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Grenoble
Severe Obesity, Type 2 Diabetes Mellitus in Obese
L-Cell Activity in Small Intestine as Biliopancreatic Loop in Obese Patients With DM2 Submitted to RYGBP
Prevalence of Obesity and its association with Diabetes Mellitus 2 (DM2) affect a significant percentage of the world's population with great socioeconomic impact, especially for developing countries.
- Trial name
- NCT05446415
- Testing
- Analyze basal expression incretin for immunolabeling and mRNA expression glucagon-like secretion peptide-1 (GLP-1) and peptide YY (PYY 3-36) incretins by L cells.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obesity
Study of VI-0521 Compared to Placebo in Treatment of Obesity in Adults
The purpose of this study is to evaluate the efficacy and safety of two doses of VI-0521 compared to placebo in treatment of obesity in an adult population with BMI ≥ 35.
- Trial name
- NCT00554216
- Testing
- VI-0521
- Where
- 5 sites in United States
- Volunteers
- 1,267 people
- Sponsor
- VIVUS LLC
Anastomotic Stricture, Morbid Obesity
Study of Proton Pump Inhibitors (PPI) to Prevent Strictures After Gastric Bypass Surgery
The purpose of this study is to determine whether suppressing acid production by administration of daily proton pump inhibitors in the early post-operative period will reduce the gastrojejunal anastomosis stricture rate in…
- Trial name
- NCT00361985
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Morbid Obesity
Liposomal Amphotericin B (AmBisome) Pharmacokinetics Given as a Single Intravenous Dose to Obese Patients (ASPEN)
Dosing guidelines for liposomal amphotericin B (AmBisome) in (morbidly) obese patients are not available. Subsequently, the pharmacokinetic profile of AmBisome in this specific patient population is still largely unknown.
- Trial name
- NCT02320604
- Testing
- Administration of study drug
- Where
- 2 sites in Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Morbid Obesity
Laparoscopic Sleeve Gastrectomy With Endoscopic Visualization
The main objective of this trial is to evaluate endoscopic visualization during a laparoscopic sleeve gastrectomy (LSG) procedure using an endoscope inserted transvaginally through a new device called a Steerable Flex Trocar…
- Trial name
- NCT00911989
- Testing
- NOTES toolbox
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ethicon Endo-Surgery
Obesity, Morbid
Randomized Controlled Trial of Fecal Microbiota Transplantation in Severe Obesity
This is a randomized, double-blinded and placebo controlled prospective trial with sixty patients to investigate the effect of fecal microbiota transplantation (FMT) on body weight in patients with severe obesity.
- Trial name
- RCTFMTOb (NCT03273855)
- Testing
- Fecal microbiota transplantation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Oxidative Stress, Morbid Obesity
A Comparison of the Effects of Desflurane and TIVA on Antioxidant System in Morbidly Obese Patients
With the development of technology, the safety of anesthesia devices and the progression of monitoring techniques affect the anesthetic management.
- Trial name
- OxSys (NCT03814577)
- Testing
- Total Antioxidant Status, Total Oxidant Status, Bispectral Index
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Inonu University
Steatohepatitis, Morbid Obesity
Transoral Endoscopic Liver Biopsy During Laparoscopic Gastric Bypass
This research is being done to evaluate the ability to obtain a liver sample using upper endoscopy rather than through a laparoscopic procedure.
- Trial name
- NCT00512512
- Testing
- Transoral Endoscopic Liver Biopsy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Morbid Obesity, Bariatric Surgery
Exercise to Fight Obesity
This clinical trial aims to determinate whether a structured exercise program, supported by telerehabilitation, can help individuals with severe obesity who are going to undergo bariatric surgery.
- Conditions
- Morbid Obesity, Bariatric Surgery, Telerehabilitation
- Trial name
- ExFO (NCT06934681)
- Testing
- Usual Care Group, Controlled exercise with telerehabilitation
- Where
- 2 sites in Spain
- Volunteers
- 72 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Morbid Obesity, PCA
Dual-chamber Patient-controlled Analgesia for Postoperative Recovery
Postoperative nausea and vomiting (PONV) are the most common complications that can occur after general anesthesia. Postoperative use of opioids and morbid obesity have been reported as risk factors of PONV.
- Conditions
- Morbid Obesity, PCA, Analgesia, PONV
- Trial name
- NCT07051109
- Testing
- multimodal analgesia via dual-chamber PCA, single regimen (only fentanyl)
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Seoul National University Bundang Hospital
Obstructive Sleep Apnea (OSA)
Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Receiving Positive Airway Pressure (PAP) Therapy
The study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial to evaluate the efficacy and safety of GZR18 injection in Chinese adult obese patients with moderate-to-severe…
- Trial name
- NCT07501832
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Morbid Obesity
Identification of Biomarkers of Response After Bariatric Surgery in Morbidly Obese Patients
The prevalence of obesity in Spain is about 21.6%. The discouraging results provided by dietary treatment, together with the lack of funding for pharmacological treatment, have led to the progressive use of bariatric surgery…
- Trial name
- PREDI-BAR (NCT03784508)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Obesity
Psychological and Psychopathological Characteristics of Patients With Obesity Candidates for Bariatric Surgery
Patients with obesity who are candidates for bariatric surgery may exhibit high rates of psychological symptoms, mostly anxiety and depression, and even full-blown mental disorders.
- Trial name
- PSICOBAR (NCT06556459)
- Testing
- Bariatric Surgery
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity
Frequency of ICAM-1 Polymorphisms in Obese Subjects
The genetic contribution to the development of obesity is now well recognized. However obesity is a polygenic disease and thus many genes are likely to be involved.
- Trial name
- NCT00436488
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Morbid Obesity Requiring Bariatric Surgery
Relationship Between Serum Resistin Levels and Reduction in Visceral Fat in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity
This study aims to investigate whether a specific protein in the blood, called resistin, can help doctors predict how much dangerous internal fat a patient will lose following weight loss surgery.
- Trial name
- NCT07564986
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sercan YUKSEL, MD