Clinical trials: Severe Pain Syndromes
Neutropenia
A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
The purpose of this study is to demonstrate the efficacy and evaluate the safety and tolerability of mavorixafor in participants with congenital or acquired primary autoimmune and idiopathic chronic neutropenic disorders who are…
- Trial name
- NCT06056297
- Testing
- Mavorixafor
- Where
- 114 sites in United States, Argentina and 23 more
- Volunteers
- 176 people
- Sponsor
- X4 Pharmaceuticals
Severe Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria
Unrelated Donor Stem Cell Transplantation
The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells…
- Conditions
- Severe Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- NCT01364363
- Testing
- Allogeneic transplantation
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Scripps Health
Bowel Perforation, Abscess
Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis
Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction In previous…
- Conditions
- Bowel Perforation, Abscess, Leakage, Peritonitis
- Trial name
- NCT01784458
- Volunteers
- 46 people
- Sponsor
- University of Ulsan
Dry Eye
Study of OT202 in Treating Moderate to Severe Dry Eye
This is a phase II study to explore the optimal dosage of OT202 in treating dry eye.
- Trial name
- NCT06435182
- Testing
- OT202 conc 0.5%, OT202 conc 0.1%
- Where
- 10 sites in China
- Volunteers
- 213 people
- Sponsor
- Ocumension Therapeutics (Shanghai) Co., Ltd
Primary Immune-Deficiency (PID) Common Variable Immune Deficiency (CVID)
Severe PID With Lymphoproliferation and Neutropenia
The purpose of this study is to analyse the phenotype in a sub-population of adults with severe primary immunodeficiency with lymphoproliferation and neutropenia and to decipher the possible pathways involved, especially under…
- Trial name
- DICEP (NCT03427593)
- Testing
- FACS analyses, Target Sequencing by NGS ( Next-generation sequencing), Whole Exome Sequencing
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Obstructive Sleep Apnea
Fentanyl Test and A Short OSAS Screening Scale for Severe Obstructive Sleep Apnea
The aim of this study was to estimate and compare the value of the preoperative fentanyl test and the short OSAS screening scale to diagnose severe obstructive sleep apnea；and to observe the required amount of hydromorphone and…
- Trial name
- NCT03705780
- Testing
- the short OSAS scale, fentanyl test
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Dry Eye Syndromes
Efficacy and Safety of AJU-S56 5% in Dry Eye Syndrome Patients
This study is planned to Evaluate the Efficacy and Safety of test drug (AJU-S56 5%) compared to control drug(vehicle) in Patients with Dry Eye Disease.
- Trial name
- NCT06291194
- Testing
- AJU-S56 5%
- Where
- South Korea
- Volunteers
- 396 people
- Sponsor
- AJU Pharm Co., Ltd.
Abacterial Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Use of Silodosin to Treat Moderate to Severe Abacterial Chronic Prostatitis/Chronic Pelvic Pain Syndrome.
The primary objective is to compare the efficacy of silodosin 4 and 8 mg once daily with placebo in the treatment of subjects with moderate to severe abacterial chronic prostatitis/chronic pelvic pain syndrome during a 12 week…
- Trial name
- NCT00740779
- Testing
- Silodosin 8 mg, Silodosin 4 mg
- Where
- 22 sites in United States
- Volunteers
- 153 people
- Sponsor
- Watson Pharmaceuticals
Dry Eye Syndrome (DES), Dry Eye
Study of Proteomic Factors in Patients With Severe Dry Eye Syndrome Treated With Autologous Serum Eye Drops.
Dry eye syndrome is a multifactorial pathology of the ocular surface. Epidemiological studies report a prevalence of 15% in adults aged between 50 and 95.
- Trial name
- Prot-CSA (NCT07632534)
- Testing
- Autologous serum eye drops, Collecting data from the medical record
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Adenosine Deaminase Deficiency, Autosomal Recessive Disorder
Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant
This pilot clinical trial studies total-body irradiation followed by cyclosporine and mycophenolate mofetil in treating patients with severe combined immunodeficiency (SCID) undergoing donor bone marrow transplant.
- Conditions
- Adenosine Deaminase Deficiency, Autosomal Recessive Disorder, Immune System Disorder, Purine-Nucleoside Phosphorylase Deficiency
- Trial name
- NCT00008450
- Testing
- Allogeneic Bone Marrow Transplantation, Cyclosporine, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Fred Hutchinson Cancer Center
Long COVID
Exercise for Health in Patients With Post-acute Sequelae of COVID-19
Background: Many patients with COVID-19 present the so-called post-acute sequelae of COVID-19 such as fatigue, post-stress discomfort, dyspnea, headache, pain mental impairment, incapacity to perform daily physical tasks ant…
- Trial name
- EJerSA-COVID (NCT05848518)
- Testing
- Rehabilitation program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona
Conjunctival Diseases, Dry Eye Syndromes
Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)
Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers…
- Trial name
- ALTESSE (NCT03358979)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Safety and Efficacy of Combined B Cell Depleting theRapy And Daratumumab In Autoimmune Encephalitis
Autoimmune encephalitis is an autoimmune disease of the central nervous system that targets neuronal autoantigens. Anti-neuronal autoantibodies are produced in patients, with anti-NMDAR antibody being the most common.Anti-NMDAR…
- Trial name
- RADIA (NCT06867991)
- Testing
- Ofatumumab combined with daratumumab, Ofatumumab, Repeated intravenous immunoglobulin/plasma exchange therapy
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- The First People's Hospital of Changzhou
Dry Eye Disease
Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).
This is a Phase 2, multi-site, double-masked, randomized, vehicle-controlled, study designed to evaluate the safety, tolerability, and efficacy in adult participants with DED.
- Trial name
- NCT07264517
- Testing
- GRF312 5%
- Where
- 10 sites in United States
- Volunteers
- 103 people
- Sponsor
- Instituto Grifols, S.A.
Obstructive Sleep Apnea
Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
The purpose of this study is to test the effectiveness of two different weight loss diets on obstructive sleep apnea (OSA) severity.
- Trial name
- NCT02251574
- Testing
- Low Calorie Diet, Very Low Calorie Diet, Standard Care
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Obstructive Sleep Apnea (OSA)
Telemonitoring With CPAP in Severe Obstructive Sleep Apnea in Primary Health Care
Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with cardiovascular, metabolic, cognitive, and psychological complications.
- Trial name
- CPAP-APS (NCT07464262)
- Testing
- CPAP Telemonitoring, CPAP Therapy
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Federal University of São Paulo
Severe Dry Eye Syndromes, Dry Eye Syndromes
Efficacy of Platelet-Rich Plasma Injection in Dry Eye Syndrome
The investigatror wants to show the efficacy of Platelet-Rich Plasma injection in lacrimal gland to restore the lacrimal secretion in patients presenting aqueous deficiency reponsible for severe dry eye syndrome.
- Trial name
- ReLIPSSO (NCT06831253)
- Testing
- injections of Platelet-Rich Plasma in lacrimal gland
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID)
Evaluation of Patients With Immune Function Abnormalities
This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.
- Conditions
- Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID), Leukocyte Adhesion Deficiency 1 (LAD), Graft Versus Host Disease (cGvHD)
- Trial name
- NCT00128973
- Where
- United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sleep Apnea, Dyslipidemias
CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea
Clinical Trial Phase IV Indication: Moderate-severe obstructive sleep apnea and dyslipidemia. Objectives: Main objective: To test whether 12 months of CPAP treatment associated with conventional pharmacological treatment improves…
- Conditions
- Sleep Apnea, Dyslipidemias, Hyperuricemia
- Trial name
- CPAPLIP (NCT06463561)
- Testing
- Continuous positive airway pressure, Hygienic-dietary recommendations and daily physical activity promotion
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Hospital Universitario La Paz
Myasthenia Gravis
Safety and Efficacy Study of Eculizumab in Patients With Refractory Generalized Myasthenia Gravis
The purpose of this study is to determine whether eculizumab is safe and effective in the treatment of patients with generalized myasthenia gravis despite treatment with various immunosuppressants, such as prednisone…
- Trial name
- NCT00727194
- Testing
- eculizumab
- Where
- 25 sites in United States, Canada and 1 more
- Volunteers
- 14 people
- Sponsor
- Alexion Pharmaceuticals, Inc.