Clinical trials: Severe Periodontitis, active
Periodontitis Stage II, Periodontitis Stage III
Development and Validation of the Periodontal Map Derived From IOS and CBCT Registration for Diagnosis and Treatment Planning in Moderate-to-severe Periodontitis
This prospective diagnostic study aims to validate the clinical utility of a "Periodontal Panoramic Map" generated by the PerioAI V2.0 system, an artificial intelligence-based platform that integrates intraoral scans and…
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis Stage IV
- Trial name
- NCT07505251
- Testing
- Perio AI V2.0 System
- Volunteers
- 80 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Acute Myocardial Infarction, Severe Periodontitis
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental…
- Conditions
- Acute Myocardial Infarction, Severe Periodontitis, Carotid Atherosclerosis
- Trial name
- PAROCARD (NCT04046237)
- Testing
- Periodontal treatment
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontitis
Efficacy and Safety of LP-005 Injection in Patients With Moderate-to-Severe Periodontitis
This is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical study designed to evaluate the clinical efficacy, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of multiple local injections…
- Trial name
- NCT07603713
- Testing
- LP-005 Injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Longbio Pharma (Suzhou) Co., Ltd.
Severe Periodontitis, Ischemic Stroke
Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke
Cardiovascular disease is the world's leading cause of death. Atherothrombosis is a common cause of ischemic stroke. A strong epidemiological link has been established between periodontitis and the risk of stroke.
- Trial name
- PerioStroke (NCT06484036)
- Testing
- periodontal treatment strategy
- Volunteers
- 157 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontitis Stage II, Periodontitis Stage III
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease.
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), Periodontitis
- Trial name
- NCT07293962
- Testing
- Normal saline irrigation, Platelet rich fibrin
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Periodontitis
Clinical Effectiveness of Oxygen-Releasing Oral Gel as an Adjunct to Scaling and Root Debridement in Patients With Severe Periodontal Pockets: A Randomized Clinical Trial
The goal of this clinical trial is to learn if adding an oxygen-releasing gel to a deep dental cleaning treatment can improve gum health more than deep cleaning alone, in adults with severe gum disease.
- Trial name
- NCT07840859
- Testing
- Topical oxygen-releasing oral gel, No intervention
- Where
- Malaysia
- Volunteers
- 38 people
- Sponsor
- Universiti Sains Malaysia
Periodontitis (Stage 3), Periodontitis Stage IV
Characterization of Small Intestinal Bacterial Overgrowth and Intestinal Barrier-Related Biomarkers in Patients With Severe Periodontitis
Periodontitis is a chronic inflammatory disease characterized by dysbiotic subgingival biofilms, inflammation, and progressive destruction of the tooth-supporting tissues.
- Conditions
- Periodontitis (Stage 3), Periodontitis Stage IV, SIBO
- Trial name
- MIRA (NCT07907224)
- Where
- Romania
- Volunteers
- 20 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Periodontitis, Periodontitis Stage II
Comparative Effects of Two Oral Antiseptics Used as an Adjuvant in the Treatment of Periodontitis
The focus of this study is on two types of mouthwashes - one containing a chlorhexidine (CHX) at 0.2% (CHX), and the other one containing CHX at a lower concentration of 0.12% with cetylpyridinium chloride (CPC).
- Conditions
- Periodontitis, Periodontitis Stage II, Periodontitis Stage III
- Trial name
- NCT06967402
- Testing
- Experimental (chlorhexidine), Control (chlorhexidine with cetylpyridinium chloride)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong