Clinical trials: Severe Pneumonia
SARS-CoV Infection, Respiratory Viral Infection
COVID-19 Testing Sample Acquisition Throughput and Efficiency
This QI project seeks to evaluate the relative test sample acquisition throughput, personal protective equipment utilization, and relative operational costs of provider-administered COVID-19 (SARS-CoV-2) nasal samples with and…
- Conditions
- SARS-CoV Infection, Respiratory Viral Infection, Personal Protective Equipment, Covid19
- Trial name
- HexapodBooth (NCT04532411)
- Testing
- Personal Protective Testing Booth
- Where
- United States
- Volunteers
- 28,948 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Covid-19, Critical Illness
MIcrovascular Dysfunction in CRitically Ill cOVID-19 Patients
Microcirculatory dysfunction appears to play a key role in the development of organ failure leading to the death of patients with coronavirus disease 2019 (Covid-19).
- Conditions
- Covid-19, Critical Illness, Hemodynamics, SARS-CoV Infection
- Trial name
- MICROVID (NCT04819802)
- Testing
- Measurement of sublingual microcirculation, Plasma sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID, COVID-19
Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)
This protocol will serve as a platform for assessing treatments for adult patients hospitalized for medical management of COVID-19 without related serious end-organ failure.
- Conditions
- COVID, COVID-19, SARS-CoV-2, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- NCT04546581
- Testing
- Hyperimmune immunoglobulin to SARS-CoV-2 (hIVIG), Remdesivir
- Where
- 39 sites in United States, Denmark and 5 more
- Volunteers
- 593 people
- Sponsor
- University of Minnesota
Severe COVID-19 Pneumonia
ANTIcoagulation in Severe COVID-19 Patients
Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may predispose patients to thrombotic disease due to a state of profound inflammation…
- Trial name
- ANTICOVID (NCT04808882)
- Testing
- Tinzaparin, Low dose prophylactic anticoagulation, Tinzaparin, High dose prophylactic anticoagulation, Tinzaparin,Therapeutic anticoagulation
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SARS-CoV Infection
Electrocardiogram Analysis in COVID-19 Patients
Electrocardiographic (ECG) evaluation of patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection. The present study involves three different phases of evaluation of the ECG traces of hospitalized…
- Trial name
- ELCOVID (NCT04367129)
- Testing
- ECG
- Where
- Italy
- Volunteers
- 1,014 people
- Sponsor
- University Hospital of Ferrara
Respiratory Distress Syndrome, Adult, Sars-CoV2
Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS
Acute Respiratory Distress Syndrome (ARDS) is a serious condition that occurs as a complication of medical and surgical diseases, has a mortality of ~40%, and has no known treatment other than optimization of support.
- Trial name
- CHILL-pilot (NCT03376854)
- Testing
- Hypothermia, Neuromuscular Blocking Agents, Standard of Care
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
COVID-19 Infection
Clinical Characteristics and Prognostic Factors of Patients With COVID-19 (Coronavirus Disease 2019)
This is a multicenter, non-interventional, retrospective study using data captured in the EHRs (Electronic Health Records) of the participating hospital sites to determine factors that predict disease prognosis and outcomes in…
- Trial name
- NCT04569851
- Where
- 2 sites in Spain
- Volunteers
- 100,000 people
- Sponsor
- Savana Research
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Personalized Dietary Advice 3 Months After Discharge From Hospitalization in Geriatrics: Effect on Nutritional Status According to Coronavirus Disease 2019 (COVID-19) Status (Positive or Negative) During Hospitalization
The principal aim of this interventional, multicentre study is to compare the impact of a follow-up by monthly telephone dietetic consultations, started 3 months after discharge from hospital, for a period of 3 months, on the…
- Trial name
- COVINUT (NCT04933929)
- Testing
- Post-hospitalization nutritional monitoring
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Gérond'if
Covid19, SARS-CoV Infection
The Effect of Melatonin and Vitamin C on COVID-19
This is a double-blind placebo controlled trial that seeks to evaluate the impact of melatonin and vitamin C on symptoms and outcomes of patients with COVID-19.
- Trial name
- NCT04530539
- Testing
- Vitamin C, melatonin, Symptom Survey
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Pneumonia Childhood
Effectiveness Trial of Day-care vs. Usual Care of Severe Pneumonia & Malnutrition in Children
Background: At present pneumonia and malnutrition have become the leading causes of mortality among <5-year-old children in developing countries.
- Trial name
- Day-care (NCT02669654)
- Testing
- Day-care management of Severe Pneumonia
- Where
- 2 sites in Bangladesh
- Volunteers
- 4,000 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pneumonia, Metagenomic Next Generation Sequencing
Second-generation Sequencing Guides the Treatment of Severe Pneumonia
Investigators plan to conduct the participants level, 1:1 randomized trial at the Central ICU and respiratory ICU of Xiangya Hospital in Changsha, China, from January 1, 2018 to December 31, 2019.
- Trial name
- NGS (NCT03884881)
- Testing
- metagenomic next generation sequencing, Conventional pathogen detection, Meropenem，Imipenem，Caspofene，Osstat
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xiangya Hospital of Central South University
COVID-19
Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19
Recent observations have suggested a role of neutrophil extracellular traps (NETs) in the pathophysiology of severe COVID-19. The aim of the study is to assess efficacy and safety of aerosolized DNase I to remove NETs and…
- Trial name
- NCT04541979
- Testing
- aerosolized DNase, NaCl
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Region Skane
Chronic Graft-versus-host-disease
Efficacy and Safety of Low-dose Ibrutinib and Itraconazole in Chronic Graft Versus Host Disease
Chronic graft-versus-host disease (cGVHD) affects 30 to 70% of Allogeneic Hematopoietic Cell Transplantation, decreases the quality of life, and increases mortality.
- Trial name
- NCT05348096
- Testing
- Low-dose ibrutinib
- Where
- Mexico
- Volunteers
- 13 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Post-COVID Condition, Fatigue Symptom
Study to Investigate the Efficacy of Abrocitinib in Adult Participants With Severe Fatigue From Post COVID Condition/Long COVID
The primary purpose of this phase 2a study is to compare the efficacy of abrocitinib to placebo in improving severe fatigue in non-hospitalized adults with symptomatic Post-COVID Condition (PCC) (also called Long COVID).
- Trial name
- CLEAR-LC (NCT06597396)
- Testing
- Abrocitinib
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Beth Israel Deaconess Medical Center
Covid19, SARS-CoV Infection
Epidemiologic Assessment of SARS-CoV-2 (COVID-19) Prevalence in Minnesota
The purpose of this epidemiologic study is to estimate the prevalence and incidence of anti-SARS-CoV-2 antibodies in at-risk, exposed, affected populations.
- Conditions
- Covid19, SARS-CoV Infection, SARS-CoV-2, Corona Virus Infection
- Trial name
- NCT04473183
- Testing
- Specimen Collection, Surveys
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
COVID - 19, Renal Transplant
Safety and Effectiveness of a Remdesivir Treatment to Prevent Severe COVID-19 in Kidney Transplant Patients
Since the start of the COVID-19 pandemic, the approach to solid organ transplantation has evolved. Transplants using organs (excluding lungs) from COVID-19-positive donors have shown short-term safety, but there is limited data…
- Conditions
- COVID - 19, Renal Transplant, SARS CoV 2 Infection
- Trial name
- COVIDKIDNEY (NCT07197164)
- Testing
- Remdesivir (RDV)
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Covid19, SARS-CoV Infection
COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
- Trial name
- COVID-FIS (NCT04537299)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Covid19, SARS-CoV Infection
COVID-19 IgG Formation in Physicians at ALGH and Their Household Members
This study is a community hospital-based study that will enhance information being obtained in similar studies taking place in France, Denmark, and China.
- Conditions
- Covid19, SARS-CoV Infection, Communicable Disease
- Trial name
- NCT04540484
- Testing
- Screening
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pneumonia, Viral, Pneumonia, Bacterial
Determinants of COVID-19 Pneumonia (MC-19)
Molecular testing (e.g PCR) of respiratory tract samples is the recommended method for the identification and laboratory confirmation of COVID-19 cases.
- Conditions
- Pneumonia, Viral, Pneumonia, Bacterial, Coronavirus Infection, Obstructive Lung Disease
- Trial name
- MC-19 (NCT04387799)
- Testing
- Serology for Covid-19
- Where
- Italy
- Volunteers
- 520 people
- Sponsor
- Catholic University of the Sacred Heart
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