Clinical trials: Severe Pneumonia
Neuromuscular Diseases, COVID-19
Efficacy of Vaccination Against COVID-19 in Patients Presenting a Neuromuscular Disease With Severe Amyotrophy
Des vaccins sont désormais disponibles en France, dont le vaccin Moderna COVID-19 qui est basé sur la technologie des ARNm. La séquence génétique qu'il contient code pour la protéine Spike (S) de l'enveloppe virale, protéine clé…
- Conditions
- Neuromuscular Diseases, COVID-19, Amyotrophy
- Trial name
- CANNEMUSS (NCT05353738)
- Testing
- Blood sample for research of anti-xoprs netralizing anti spike, Questionnaire
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Bordeaux
COVID-19, ECMO
Safety and Effectiveness of Low-flow ECMO Driving by CVVH Machine in Severe NCP
assess the safety and effectiveness of using low-flow extracorporeal membrane oxygenation(CO2 removal) driving by CVVH machine in the severe NCP patients
- Trial name
- NCT04340414
- Testing
- Low flow ECMO driving by CVVH machine
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
COVID-19
Specimen Collection Study From Coronavirus Disease 2019 (COVID-19) Vaccinated Adults and Adolescents
This is a specimen collection study intended to generate a biological specimen repository of samples from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults and adolescents ≥12 years old who will receive…
- Trial name
- CoVacSpec (NCT05252910)
- Where
- 32 sites in United States, Colombia and 5 more
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pharm-Olam, LLC
Covid19, SARS-CoV Infection
Study of Oral Administration of Ribavirin and Nitazoxamide Versus Placebo in COVID-19
This is a single center, randomized, double-blind, 2-arm, parallel-group study of DuACT in participants with clinical symptoms of COVID-19 that have begun within the past 72 hours prior to testing.
- Trial name
- DuACT (NCT04563208)
- Testing
- DuACT
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- University of Witwatersrand, South Africa
COVID-19
A Study to Measure the Amount of Study Medicine in Blood in Adult Participants With COVID-19 and Severe Kidney Disease
The purpose of this study is to learn about the side effects (safety) of the study medicine PF-07321332 (nirmatrelvir)/ritonavir for the treatment of mild to moderate COVID-19 infection in adults with severe renal impairment.
- Trial name
- NCT05487040
- Testing
- PF-07321332 (nirmatrelvir)/ritonavir
- Where
- 52 sites in United States
- Volunteers
- 15 people
- Sponsor
- Pfizer
Asymptomatic Condition, Infection Viral
ScreenNC, a Study to Determine the Number of Asymptomatic Individuals Who Have Antibodies to the Virus That Causes COVID-19
Purpose: To determine the number of asymptomatic individuals who have antibodies to SARS-CoV-2, the virus which causes COVID-19
- Conditions
- Asymptomatic Condition, Infection Viral, Coronavirus Infections, Severe Acute Respiratory Syndrome Coronavirus 2
- Trial name
- NCT04367740
- Testing
- To assess for development of IgG antibodies against SARS-CoV2
- Where
- United States
- Volunteers
- 6,313 people
- Sponsor
- University of North Carolina, Chapel Hill
COVID-19
A Study of Efficacy and Safety of Azvudine vs. Nirmatrelvir-Ritonavir in the Treatment of COVID-19 Infection
The COVID-19 pandemic has become a major public health challenge, and the treatment options for the disease are currently limited.
- Trial name
- NCT05697055
- Testing
- Azvudine, Nirmatrelvir-Ritonavir
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Shandong Provincial Hospital
SARS CoV 2 Infection, Hypoxemic Respiratory Failure
Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient
Introduction: The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure…
- Trial name
- NCT04995289
- Testing
- Prone position on ECMO patient
- Where
- Morocco
- Volunteers
- 23 people
- Sponsor
- Mohammed VI University Hospital
Community-acquired Pneumonia, Hospital-acquired Pneumonia
Diagnostic Performance and Impact of a Multiplex PCR Pneumonia Panel in ICU Patients With Severe Pneumonia.
The objective of this study is to assess the diagnostic performance of multiplex respiratory PCR (PCR-RM) compared to standard microbiological tests and its potential impact on the early adaptation of antibiotic treatment in…
- Conditions
- Community-acquired Pneumonia, Hospital-acquired Pneumonia, Ventilator Associated Pneumonia
- Trial name
- NCT05624684
- Testing
- Multiplex respiratory PCR
- Where
- Morocco
- Volunteers
- 210 people
- Sponsor
- Avicenna Military Hospital
Covid19
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)
The primary objective of this study is to evaluate the efficacy of BGB-DXP593 administered intravenously as a single dose in participants with mild to moderate COVID-19
- Trial name
- NCT04551898
- Testing
- BGB-DXP593
- Where
- 18 sites in United States, Brazil and 2 more
- Volunteers
- 181 people
- Sponsor
- BeiGene
Tracheostomy Complication, Acquired Brain Injury
Cough Assessment in Patients With Severe Acquired Brain Injury
The cough assessment is fundamental in the weaning process as it gives information on the possibility to expel food and secretion out from the airways.
- Conditions
- Tracheostomy Complication, Acquired Brain Injury, Brain Injury, Pneumonia
- Trial name
- NCT02495558
- Testing
- Reflex Cough Test
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Leukemia, Acute, Covid19
Clinical Characteristics of Patients With Leukemia and COVID-19
The purpose of this study is to describe the main clinical characteristics of patients with de novo acute lymphoblastic leukemia treated inside the third level hospitals converted to Coronavirus disease 2019 (COVID-19) attention…
- Conditions
- Leukemia, Acute, Covid19, Leukemia, Lymphoblastic
- Trial name
- NCT04745416
- Where
- 2 sites in Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital General de Mexico
COVID-19, Coronavirus
A Study to Assess Pulsed Inhaled Nitric Oxide vs Placebo in Subjects With Mild or Moderate COVID-19
A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of pulsed inhaled iNO compared to placebo in subjects with COVID-19.
- Conditions
- COVID-19, Coronavirus, Coronavirus Infection
- Trial name
- COViNOX (NCT04421508)
- Testing
- INOpulse
- Where
- 17 sites in United States
- Volunteers
- 191 people
- Sponsor
- Bellerophon Pulse Technologies
Covid19
Study of F-652 (IL-22:IgG2 Fusion Protein) in Patients With Moderate to Severe COVID-19
This is an interventional, multicenter, 2-arm, parallel-group, randomized, double-blind, placebo controlled, dose-escalation, safety and efficacy study of F-652 treatment versus placebo in patients aged 18 years or older with a…
- Trial name
- NCT04498377
- Testing
- F-652
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- EVIVE Biotechnology
2019 nCoV, PD-1
Immunoregulatory Therapy for 2019-nCoV
Sepsis, including viral infections, are major causes of death worldwide. Studies show that in 2017, the number of sepsis patients worldwide reached as high as 48.9 million, of which 11 million patients died.
- Trial name
- NCT04268537
- Testing
- PD-1 blocking antibody+standard treatment, Thymosin+standard treatment, standard treatment
- Volunteers
- 120 people
- Sponsor
- Southeast University, China
COVID-19
Traditional Chinese Medicine for Severe COVID-19
In December 2019, a new type of pneumonia, COVID-2019 outbroke in Wuhan ,China, and currently the infected has been reported in more than at least 75 countries.
- Trial name
- NCT04323332
- Testing
- Traditional Chinese Medicine Prescription
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Psoriasis, Skin Diseases
A Phase 2b Study of Baricitinib in Participants With Moderate to Severe Psoriasis
This is a dose-ranging study designed to investigate the efficacy and safety of Baricitinib in the treatment of participants with moderate to severe, chronic plaque psoriasis as assessed by the Psoriasis Area and Severity Index…
- Conditions
- Psoriasis, Skin Diseases, Skin Diseases, Papulosquamous
- Trial name
- NCT01490632
- Testing
- Baricitinib
- Where
- 35 sites in United States, Canada and 2 more
- Volunteers
- 271 people
- Sponsor
- Eli Lilly and Company
Covid19, SARS-CoV Infection
A Registry Study of COVID-19 Serologic and Virologic Testing to Accelerate Recovery and Transition
The co-primary objectives of this study are to: 1. Determine and compare the COVID-19 antibody positivity rate in health care workers and patients without a known COVID-19 infection 2.
- Trial name
- START (NCT04573634)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jill M Kolesar
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
COVID-19
Cohort of Patients Infected With SARS-CoV2 (COVID-19) or Suspected of Being
On 17th March 2020, 198 193 confirmed cases (7 730 in France) of COVID-19 infections and 7 854 deaths (175 in France) have been reported from 8th December 2019 in 157 countries.
- Trial name
- COVIDeF (NCT04352348)
- Testing
- blood samples, feces samples (COVI-BIOME ancillary study), sweat samples (COVIDOG ancillary study)
- Where
- France
- Volunteers
- 2,003 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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