Clinical trials: Severe Pneumonia
Covid19
Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection
Prospective, cross-sectional study evaluating the effect of commercially available mouthwashes on expelled/exhaled SARS-CoV-2 viral load using face mask sampling.
- Trial name
- NCT04931004
- Testing
- Mouthwash Product
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
COVID-19
Study to Evaluate the Safety and Efficacy of Prolastin in Hospitalized Subjects With COVID-19
The primary objective of the study is to determine if Prolastin plus SMT can reduce the proportion of subjects dying or requiring intensive care unit (ICU) admission on or before Day 15 or who are dependent on invasive mechanical…
- Trial name
- NCT04495101
- Testing
- Prolastin, Standard Medical Treatment
- Where
- 9 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Instituto Grifols, S.A.
Covid19
Effectiveness and Safety Study of Specific Hyperimmune Equine Serum for the Treatment of Severe Hospitalized SARS-CoV-2 in Adults: Retrospective Cohort Study
An observational, retrospective, classic cohort study of adult patients hospitalized for severe pneumonia with a diagnosis of SARS-CoV-2 by RT-PCR will be carried out.
- Trial name
- NCT04954235
- Where
- Argentina
- Volunteers
- 847 people
- Sponsor
- Inmunova S.A.
SARS-COV2, COVID19
Identifying Functional and Psycho-social Complaints After Hospitalization for SARS-CoV-2 Infection( COVID 19)- REPERCOV
Since December 2019, China and then the rest of the world have been affected by the rapid spread of a new coronavirus infection called SARS-CoV-2 (severe acute respiratory syndrome coronavirus), the clinical expression of which…
- Trial name
- REPERCOV (NCT04561154)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Centre Hospitalier le Mans
COVID-19
Effectiveness of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19
The purpose of this pragmatic randomized trial is to evaluate the vaccine effectiveness of the COVID-19 vaccine, mRNA-1273, in adults aged 50-64 years without known risk factors for severe COVID-19 infection.
- Trial name
- DAN-COVID (NCT07279766)
- Testing
- mRNA-1273 (Moderna COVID-19 vaccine)
- Where
- 2 sites in Denmark
- Volunteers
- 41,060 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Personalized Dietary Advice 3 Months After Discharge From Hospitalization in Geriatrics: Effect on Nutritional Status According to Coronavirus Disease 2019 (COVID-19) Status (Positive or Negative) During Hospitalization
The principal aim of this interventional, multicentre study is to compare the impact of a follow-up by monthly telephone dietetic consultations, started 3 months after discharge from hospital, for a period of 3 months, on the…
- Trial name
- COVINUT (NCT04933929)
- Testing
- Post-hospitalization nutritional monitoring
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Gérond'if
Severe Pneumonia
Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells for the Treatment of Severe Viral Pneumonian
The purpose of this clinical study is to answer the questions: 1. Is the proposed intervention safe? 2. Is the proposed intervention effective in improving the health of subjects with severe viral pneumonia？
- Trial name
- NCT04282928
- Testing
- Human umbilical cord mesenchymal stem cells, Routine treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai East Hospital
Severe Pneumonia, Hypoxemia
Impact of Pulse Oximetry on Hospital Referral Acceptance in Children Under 5 With Severe Pneumonia
The study assesses and compares the effect of 'pulse oximetry' (PO) used by Lady Health Workers (LHWs) at household level on increasing hospital referral acceptance rates in intervention clusters (district Jamshoro) for 0-59…
- Trial name
- NCT03588377
- Testing
- Pulse Oximetry
- Where
- Pakistan
- Volunteers
- 543 people
- Sponsor
- Aga Khan University
Ventilator Associated Pneumonia, Critical Care
Delayed Antibiotic Therapy in Non-severe Ventilator Acquired Pneumonia (VAP)
This retro-prospective monocentric observational study compare the impact of the implementation of a restrictive (delayed) versus aggressive (immediate) antibiotic strategy for Ventilator Acquired Pneumonia suspicion without…
- Conditions
- Ventilator Associated Pneumonia, Critical Care, Antibiotic Therapy
- Trial name
- DELAVAP (NCT05205525)
- Testing
- Restrictive antibiotic strategy, Aggressive antibiotic strategy
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Nantes University Hospital
COVID-19, Coronavirus Infection
Beaumont Health Large-scale Automated Serologic Testing for COVID-19
The purpose of this study is to determine how peoples' bodies respond to exposure to COVID-19. Employees of Beaumont Health in Michigan who are older than 18 years may be eligible to participate.
- Conditions
- COVID-19, Coronavirus Infection, Severe Acute Respiratory Syndrome Coronavirus 2
- Trial name
- BLAST COVID-19 (NCT04349202)
- Testing
- EUROIMMUN assay
- Where
- 2 sites in United States
- Volunteers
- 20,614 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
GVHD, Chronic
TDI01 Suspension in the Treatment of Chronic Graft-versus-host Disease (cGVHD))
1. Phase Ib study stage: Primary objective: To evaluate the efficacy and safety Secondary objectives: To evaluate the population pharmacokinetic characteristics 2.
- Trial name
- NCT06169722
- Testing
- TDI01 suspension
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tide Pharmaceutical Co., Ltd
Pneumonia, Staphylococcal
Vancomycin Dosage Strategy Based on a Trough Concentration Model
Study design: Allocation: Randomized Endpoint classification: Efficacy study Masking: Open label Primary purpose: Treatment Primary endpoint: Incidence of reaching the target serum trough concentration Secondary endpoint…
- Trial name
- NCT04088305
- Testing
- Individualized therapy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
2019 nCoV, PD-1
Immunoregulatory Therapy for 2019-nCoV
Sepsis, including viral infections, are major causes of death worldwide. Studies show that in 2017, the number of sepsis patients worldwide reached as high as 48.9 million, of which 11 million patients died.
- Trial name
- NCT04268537
- Testing
- PD-1 blocking antibody+standard treatment, Thymosin+standard treatment, standard treatment
- Volunteers
- 120 people
- Sponsor
- Southeast University, China
Covid19, Hydrogen-oxygen Gas
Hydrogen-oxygen Gas Mixture Inhalation in Patients With Convalescent Coronavirus Disease 2019 (COVID-19)
This study is a multicenter, randomized, open, parallel-controlled study. Qualified subjects will randomly be assigned to the experimental arm or the control arm according to the ratio of 1:1, with age (> 60 years or ≤ 60 years)…
- Conditions
- Covid19, Hydrogen-oxygen Gas, AMS-H-03
- Trial name
- NCT04594460
- Testing
- Hydrogen-Oxygen Generator with Nebulizer, AMS-H-03, OLO-1 Medical Molecular Sieve Oxygen Generator
- Where
- 2 sites in China
- Volunteers
- 198 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Covid-19, Pulmonary Fibrosis
Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection (COVID-19)
COVID-19, the infectious disease caused by the novel coronavirus SARS-CoV-2, currently poses a global economic, social, political and medical challenge.
- Trial name
- CovILD (NCT04416100)
- Testing
- Pulmonary function tests, Imaging, Blood sampling
- Where
- Austria
- Volunteers
- 130 people
- Sponsor
- Medical University Innsbruck
Covid-19, Coronavirus Disease 2019
A Placebo Controlled Trial of Bempegaldesleukin (BEMPEG; NKTR-214) With Standard of Care in Patients With Mild COVID-19
The main purpose of this phase-1b, multicenter, randomized double-blind, placebo-controlled, trial is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of bempegaldesleukin (BEMPEG; NKTR-214) in…
- Trial name
- NCT04646044
- Testing
- Bempegaldesleukin, Standard of Care
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nektar Therapeutics
Severe Infections Pneumonia With Invasive Ventilation in PICU
RAPid SOlution for Diagnosis of Respiratory Infection in Pediatric Intensive Care Unit
In patients with infectious pneumonitis, the FILMARRAY® Pneumonia Plus Panel technique (multiplex PCR) on a respiratory sample makes it possible to identify the responsible pathogen and its resistance to antibiotics in less than…
- Trial name
- RAPSODI (NCT04773704)
- Testing
- FILMARRAY® Pneumonia Plus Panel technique
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19
Ivermectin which is an FDA-approved broad spectrum anti-parasitic agent, has also anti-viral activity. In vitro study have shown its activity against SARS-CoV-2, however its clinical effect on patients with COVID-19 never been…
- Trial name
- NCT04429711
- Testing
- Ivermectin Oral Product
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
COVID-19
AZD7442 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
This study looks at the safety and effectiveness of AZD7442 in treating COVID-19 in people who have been hospitalized with the infection.
- Trial name
- NCT05780437
- Testing
- AZD7442, Remdesivir
- Where
- 124 sites in United States, Denmark and 7 more
- Volunteers
- 1,455 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Severe Acute Respiratory Syndrome Coronavirus 2 Infection
A Clinical Trial to Study the COVAC-1 Booster Dose in Generally Healthy Adults
VIDO has developed a vaccine called COVAC-1. The COVAC-1 study vaccine contains a portion of the SARS-CoV-2 spike protein, called S1.
- Trial name
- NCT05693272
- Testing
- COVAC-1
- Where
- 4 sites in Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
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