Clinical trials: Severe Pneumonia
COVID-19
A Study to Evaluate Safety and Efficacy of Convalescent Methylene Blue Treated (MBT) Plasma From Donors Recovered From Coronavirus Disease 2019 (COVID-19)
The purpose of the study is to determine if Convalescent anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Methylene Blue Treated (MBT) plasma plus Standard Medical Treatment (SMT) can reduce all-cause mortality…
- Trial name
- NCT04547127
- Testing
- Convalescent anti-SARS-CoV-2 MBT Plasma, Standard Medical Treatment
- Where
- 12 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Instituto Grifols, S.A.
Covid19, Corona Virus Infection
Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS
ULSC-CV-01 is a clinical trial that comprises both Phase 1 and Phase 2a, which will be conducted sequentially. This trial will evaluate the safety and potential efficacy of allogeneic Umbilical Cord Lining Stem Cells (ULSC)…
- Conditions
- Covid19, Corona Virus Infection, SARS-CoV Infection, ARDS
- Trial name
- ULSC (NCT04494386)
- Testing
- Umbilical Cord Lining Stem Cells (ULSC)
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Restem, LLC.
Covid19, SARS (Severe Acute Respiratory Syndrome)
A Study To Evaluate The Performance of the Lucira Health All-In-One COVID-19 Test Kit vs Hologic Panther Fusion
This Lucira COVID-19 All-In-One Test Kit performance study will be used to establish the performance of the Lucira COVID-19 All-In-One Test Kit as compared to a known high sensitivity RT-PCR molecular assay.
- Conditions
- Covid19, SARS (Severe Acute Respiratory Syndrome), Corona Virus Infection
- Trial name
- NCT04720794
- Testing
- Lucira COVID-19 All-In-One test kit
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Lucira Health Inc
COVID-19
Convalescent Plasma as Adjunct Therapy for COVID-19
Convalescent plasma (CP) has been the subject of increasing expectation for treating coronavirus disease 2019 (COVID-19). Reports on CP transfusion have shown promising clinical improvements without serious adverse events.
- Trial name
- PlaSenTer (NCT04873414)
- Testing
- Convalescent plasma treatment
- Where
- 28 sites in Indonesia
- Volunteers
- 364 people
- Sponsor
- National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
Covid19, Severe COVID-19 Patients
Role of Co-trimoxazole in Severe COVID-19 Patients
Coronavirus Disease 19 (COVID-19) is a global pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Severe disease occurs in 15% of the cases with COVID-19 and may progress to critical disease in only…
- Trial name
- NCT04470531
- Testing
- oral co-trimoxazole
- Where
- Bangladesh
- Volunteers
- 94 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
COVID-19, Pneumonia
Extra Vascular Lung Water and Pulmonary Permeability in Critically Ill Patients With SARS-CoV-2 (COVID-19)
Acute respiratory distress syndrome (ARDS) is a syndromic definition of an acute lung injury with alteration of biomechanics (lower respiratory system compliance) mostly associated with increased lesional edema.
- Conditions
- COVID-19, Pneumonia, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04376905)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
COVID
Avdoralimab an Anti-C5aR Antibody, in Patients With COVID-19 Severe Pneumonia ( FORCE )
The primary objective of this trial is to improve the proportion of COVID-19 patients with severe pneumonia who no longer need to be hospitalized, and to reduce the need for and duration of mechanical ventilation in patients with…
- Trial name
- FORCE (NCT04371367)
- Testing
- avdoralimab
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
COVID-19, Acute Kidney Injury
Applying Artificial Intelligence to Identify Subphenotypes of Acute Kidney Injury in Mexican Patients With Severe COVID-19
The goal of this observational study was to identify subphenotypes of acute kidney injury patients with COVID-19, and the investigators analyzed their impact on mortality.
- Trial name
- IA-COVAKI (NCT06471101)
- Testing
- clusters
- Where
- Mexico
- Volunteers
- 2,934 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
COVID-19
Efficacy and Safety of XAV-19 for the Treatment of Moderate-to-severe COVID-19
The purpose of this study is to evaluate the efficacy and safety of XAV-19 drug in patients with moderate-to-severe COVID-19.
- Trial name
- NCT04928430
- Testing
- XAV-19
- Where
- 18 sites in Bulgaria, Greece and 3 more
- Volunteers
- 290 people
- Sponsor
- Xenothera SAS
Psittacosis
Adaptive RCT of Corticosteroids for Severe Chlamydia Psittaci Pneumonia in Adults
Severe community-acquired pneumonia caused by psittacosis is a form of atypical-pathogen community-acquired pneumonia that often requires critical care management.
- Trial name
- NCT07352865
- Testing
- Saline (0.9%, sterile, for infusion), low dose Methylprednisolone, Moderate dose Methylprednisolone
- Volunteers
- 100 people
- Sponsor
- Qingyuan Zhan
COVID-19, Coronavirus Infections
Safety, Tolerability, and Immunogenicity of Trivalent Coronavirus Vaccine Candidate VBI-2901a
VBI-2901a is an investigational vaccine candidate that uses enveloped virus-like particles (eVLPs) to express the spike proteins of three coronaviruses: SARS-CoV-2 (the virus that causes COVID-19 disease), SARS-CoV-1 and…
- Trial name
- NCT05548439
- Testing
- VBI-2901a
- Where
- 7 sites in Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.
Covid19
Short Term, High Dose Vitamin D Supplementation in Moderate to Severe COVID-19 Disease
COVID-19 caused by SARS-CoV-2 virus has affected the lives of millions of individuals globally and also severely strained the medical community.
- Trial name
- SHADE-S (NCT04952857)
- Testing
- cholecalciferol 6 lakh IU
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pneumonia, Pneumocystis Carinii, HIV Infections
Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
To compare the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium) with that of conventional therapy (sulfamethoxazole-trimethoprim) in the treatment of moderately severe…
- Trial name
- NCT00001014
- Testing
- Trimetrexate glucuronate, Sulfamethoxazole-Trimethoprim, Leucovorin calcium
- Where
- 6 sites in United States
- Volunteers
- 302 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Renal Insufficiency, Chronic
Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney Disease
This is a prospective, single-center, open and self-controlled study.The purpose of this study is to evaluate the efficacy and safety of Paxlovid for the treatment of COVID-19 patients with severe chronic kidney disease.
- Trial name
- ESPTCSCKD (NCT05938140)
- Testing
- Nirmatrelvir/ritonavir
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Severe Pneumonia
Dynamic Pattern of Etiology, Immunoinflammatory Factors and Their Association With Prognosis of Severe Pneumonia
The goal of this longitudinal observational study is to investigate the pathogen spectrum composition of severe pneumonia (SP) in different disease stages and to study the changes of immune inflammatory factors in patients with…
- Trial name
- NCT06538441
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai General Hospital, China
Pneumocystis, HIV/AIDS
Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS
The treatment guidelines for Pneumocystis pneumonia (PCP) suggest adding 40mg of prednisone (or its equivalent in methylprednisolone) twice per day on days 1 through 5, 40 mg days 6 through 10, and 20 mg daily on days 11 through…
- Conditions
- Pneumocystis, HIV/AIDS, Steroid
- Trial name
- NCT03856229
- Testing
- Conventional steroid regimen, Shortened steroid regimen
- Where
- Mexico
- Volunteers
- 196 people
- Sponsor
- Centro de Investigación en. Enfermedades Infecciosas, Mexico
COVID-19
Hydroxychloroquine Use in Hospitalized Patients With COVID-19: Impact on Progression to Severe or Critical Disease
The primary objective is to assess the impact of hydroxychloroquine in hospitalized patients with COVID-19 and risk factors for severe/critical disease.
- Trial name
- NCT04429867
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- WellStar Health System
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
Covid19
Short and Long-term Effects of Adding Oral L-arginine to Standard Therapy in Patients With COVID-19 (SARS-CoV-2)
Single-center study with a parallel group scheme, double-blind, randomized, placebo-controlled, to evaluate whether the addition to the investigator's hospital standard therapy of two vials of Bioarginina® per day in subjects…
- Trial name
- NCT04637906
- Testing
- Bioarginina®
- Where
- Italy
- Volunteers
- 290 people
- Sponsor
- University of Campania Luigi Vanvitelli
Coronavirus Infections
Investigating Effect of Convalescent Plasma on COVID-19 Patients Outcome: A Clinical Trial
Coronavirus disease 2019 (COVID-19) was recognized as a pandemic on March 11, 2020 by the World Health Organization. The virus that causes COVID-19 (SARS-CoV-2) is easily transmitted through person to person and there is still no…
- Trial name
- NCT04327349
- Testing
- Convalescent Plasma
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Mazandaran University of Medical Sciences
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