Clinical trials: Severe Pre-eclampsia
Preeclampsia Severe
Nicardipine and Labetalol Effects on Cerebral Hemodynamics in Preeclampsia
Realization of transcranial doppler and optic nerve sheath in severe preeclamptic patients to evaluate the impact of nicardipine and labetalol on cerebral hemodynamics.
- Trial name
- PREMODYM (NCT03761888)
- Testing
- optic nerve sheath measurement and transcranial doppler
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hopital Antoine Beclere
Magnesium Sulfate, Labetalol
Evaluation of Intravenous Infusion of Labetalol Versus Magnesium Sulfate
the purpose of this study is to compare Intravenous infusion of Labetalol versus Magnesium Sulfate on Cerebral Hemodynamics of Severe Preeclampsia Patients using Transcranial Doppler
- Trial name
- NCT04539379
- Testing
- Magnesium sulfate, Labetolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Preeclampsia Severe, Cardiovascular Diseases
Postpartum Low-Dose Aspirin After Preeclampsia for Optimization of Cardiovascular Risk (PAPVASC)
Women who develop preeclampsia (PE) in pregnancy are at a greater risk for adverse cardiovascular health outcomes. PE is associated with vascular remodeling and functional changes in the postpartum, reflective of its systemic…
- Conditions
- Preeclampsia Severe, Cardiovascular Diseases, Primary Prevention
- Trial name
- PAPVASC (NCT04243278)
- Testing
- Low-dose aspirin
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Dr. Graeme Smith
Preeclampsia Severe
Uterotonics for Severe Preeclampsia
The study compares the effect of Intravenous carbetocin versus combined use of intravenous oxytocin and rectal misoprostol for prevention of postpartum hemorrhage during delivery of women with severe preeclampsia
- Trial name
- NCT04756661
- Testing
- Carbetocin, Oxytocin, Misoprostol
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Assiut University
Patient Satisfaction
Patient Satisfaction With Abbreviated Postpartum Magnesium Sulfate for Severe Preeclampsia
Preeclampsia is a common and potentially devastating disease that affects only pregnant or postpartum patients. It is a leading cause of maternal mortality not only worldwide, but in the United States as well.
- Trial name
- NCT05789381
- Testing
- Magnesium sulfate
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Severe Preeclampsia
Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia
Magnesium sulfate is the ideal drug for seizures prophilaxis in preeclampsia. The ideal duration of this treatment after delivery is still to be established.
- Trial name
- MgSO4 (NCT01408979)
- Testing
- Magnesium sulfate 12 hours, Magnesium sulfate 24 hours
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Preecalmpsia
Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia
Preeclampsia with severe features remains a leading contributor to maternal morbidity and mortality, particularly in low- and middle-income countries.
- Trial name
- NCT07443345
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Severe Pre-eclampsia
Rosuvastatin in Order to Induce Preeclampsia Resolution in Severe PET up to 48 Hours Following Delivery
Prospective randomized single blind trial. Study population are women diagnosed with severe pre-eclampsia during singleton pregnancy, between 24+0 weeks and 41+6 weeks gestational age.
- Trial name
- NCT02314286
- Testing
- Rosuvastatin
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Pregnancy Complications, Preeclampsia
Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity
Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction…
- Conditions
- Pregnancy Complications, Preeclampsia, Placental Abruption, Intrauterine Fetal Growth Restriction
- Trial name
- NCT00573118
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Preeclampsia Severe, Preeclampsia Postpartum
Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on…
- Trial name
- PANDA (NCT03978767)
- Testing
- Ibuprofen 600 mg, Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Washington University School of Medicine
Pre-Eclampsia, Severe, Pregnancy
Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia
The goal of this observational study is to determine whether noninvasive finger plethysmographic cardiac output monitoring can help predict fluid responsiveness in pregnant women, including those with preeclampsia with severe…
- Trial name
- NCT07430254
- Testing
- Noninvasive finger plethysmographic cardiac output monitoring, Standard transthoracic echocardiographic assessment
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction
Randomized Controlled Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients.
Severe Hypertension in pregnancy demands urgent treatment because of high mortality \& morbidity in obstetric patients. Hydralazine, the most commonly used agent, causes sudden hypo tension and tachycardia.
- Conditions
- Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction, Pre-eclampsia, Pre-eclampsia Superimposed Pre-existing Hypertension
- Trial name
- NCT02050529
- Testing
- Labetalol, Hydralazine
- Where
- Pakistan
- Volunteers
- 190 people
- Sponsor
- Dow University of Health Sciences
Preeclampsia (PE), Intrauterine Growth Restriction (IUGR)
Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
In pregnancies with placental insufficiency, the only available treatment is close monitoring to determine the point at which the risks of preterm birth for the baby are lower than the risks of continuing the pregnancy.
- Conditions
- Preeclampsia (PE), Intrauterine Growth Restriction (IUGR), Placental Insufficiency
- Trial name
- STATIN-PRE (NCT07098975)
- Testing
- Pravastatin 40 mg
- Where
- 2 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Adverse Effect
The Potency of Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the potency between prophylactic norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in patients with severe preeclampsia during caesarean section.
- Trial name
- NCT05035472
- Testing
- Phenylephrine, Norepinephrine
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Preeclampsia Severe
Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor
This is a randomized double blind placebo controlled trial comparing Nifedipine 30mg XL to placebo in 110 patients after decision has been made to proceed with induction of labor for the diagnosis of preeclampsia with severe…
- Trial name
- NCT04392375
- Testing
- Nifedipine 30 MG
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Ohio State University
Preeclampsia (PE)
Different Regimens of Magnesium Sulphate in Patients With Severe Preeclampsia
The goal of this observational study is to learn about the effects of the different drug regimens of magnesium sulphate in treatment of (severe pre-eclampsia).
- Trial name
- NCT06791668
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Ain Shams Maternity Hospital
Inflammatory Markers, Preeclampsia Severe
Assessment of Maternal and Fetal Serum Biomarkers in Women With Pre-eclampsia
The findings of markers of placental dysfunction in women with preeclampsia may suggest that these biomarkers may be useful tools for early detection of preeclampsia
- Conditions
- Inflammatory Markers, Preeclampsia Severe, Preeclampsia Mild, Umbilical Cord Issue
- Trial name
- NCT06712550
- Where
- Iraq
- Volunteers
- 204 people
- Sponsor
- SHAHLA KAREEM ALALAF
Preeclampsia Severe
Effect of Magnesium Sulphate on the Intracranial Pressure of Preeclamptic Patients
It had been shown that high percentage of severe preeclampsia patients got a high cerebral perfusion pressure (CPP) due to abnormal autoregulation of cerebral blood vessels with associated endothelial dysfunction and disrupted…
- Trial name
- NCT03210350
- Testing
- Optic nerve sheath diameter
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Corniche Hospital
Pre-eclampsia
New Magnesium Sulphate Protocol for Pre-eclampsia
there is a standard magnesium sulphate protocol and newer protocols for pre-eclampsia, we need to make a trial to find the best protocol
- Trial name
- NCT01846156
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Cairo University
Preeclampsia With Severe Features
Nifedipine Dosing Daily vs Twice a Day for Pre-eclampsia With Severe Features (NOPPI)
The investigators propose a randomized controlled unblinded trial to evaluate rates of optimal blood pressure control between Nifedipine 60mg XL once daily vs.
- Trial name
- NCT05096728
- Testing
- Nifedipine XL
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University