Clinical trials: Severe Respiratory Infection
Pneumonia
Effectiveness Study of Integrative Treatment for Pediatric Pneumonia
The purpose of this study is to evaluate the effectiveness of traditional Chinese medicine for treatment of pediatric pneumonia. It is a multicenter randomized controlled trial.
- Trial name
- NCT02069665
- Testing
- Fuxiong San, Xiyanping injection, Ribavirin Injection
- Where
- 6 sites in China
- Volunteers
- 451 people
- Sponsor
- Liaoning University of Traditional Chinese Medicine
Severe Viral Bronchiolitis
Work of Breathing in Bronchiolitis Under Non-invasive Ventilation
Severe acute viral bronchiolitis is the leading cause of pediatric intensive care admission. The first-line recommended ventilation support is continuous positive airway pressure (CPAP), which reduces the work of breathing (WOB)…
- Trial name
- BRONCHIO-VNI (NCT04677556)
- Testing
- Esogastric pressures measurement
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
A COVID-19 Study to Evaluate Safety and Pharmacokinetics of COVID-HIGIV Administered in Healthy Adults
This study is designed to evaluate three dose levels of Anti-SARS-CoV-2 Immunoglobulin Intravenous (Human) (COVID-HIGIV) for safety and pharmacokinetics (PK) in healthy adults.
- Trial name
- NCT04661839
- Testing
- COVID-HIGIV
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
COVID-19, Intensive Care Unit
Zooming in on Cerebral Abnormalities in Severely Affected COVID-19 Patients
Brain injury is one of the complications in COVID-19 intensive care unit (ICU) survivors, though the precise underlying mechanism is unclear.
- Trial name
- ZoomCOVID (NCT05197296)
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Maastricht University Medical Center
Covid19
Convalescent Plasma for Severe COVID-19 Patients
Plasma, the supernatant part of blood, contains a variety of different proteins, including immunoglobulins. These proteins, also called antibodies, are directed to previous foreign infecting organisms, such as virus, bacteria or…
- Trial name
- PLACOVID (NCT04547660)
- Testing
- Convalescent Plasma, Best Supportive Care
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COVID-19
Tocilizumab for Prevention of Respiratory Failure in Patients With Severe COVID-19 Infection
The purpose of this study is to find out whether the study drug tocilizumab is an effective treatment for COVID-19 infection.
- Trial name
- NCT04377659
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
COVID-19
Phase I-II Trial of Dendritic Cell Vaccine to Prevent COVID-19 in Adults
This is an adaptive Phase I-II trial of a vaccine consisting of autologous dendritic cells previously loaded ex vivo with SARS-CoV-2 spike protein, with or without GM-CSF, to prevent COVID-19 in adults.
- Trial name
- NCT04386252
- Testing
- AV-COVID-19
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aivita Biomedical, Inc.
COVID-19, Coronavirus Disease 2019
A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza.
The main purpose of this study is to understand: the symptoms of COVID-19 or influenza health-related outcomes of people with COVID-19 or influenza the effects of vaccines in people with COVID-19 or influenza.
- Conditions
- COVID-19, Coronavirus Disease 2019, Influenza
- Trial name
- NCT06163677
- Testing
- COVID-19 Vaccine
- Sponsor
- Pfizer
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Follow-up of Covid-19 Long Term Sequelae
The protocol, in accordance with the objectives of ORCHESTRA project - Work Package 2, aims at investigating the characteristics and determinants of COVID-19 long-term sequelae.
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05097677
- Testing
- Not applicable (observational study)
- Where
- 7 sites in Belgium, France and 4 more
- Volunteers
- 7,599 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Covid19
Short Term, High Dose Vitamin D Supplementation in Moderate to Severe COVID-19 Disease
COVID-19 caused by SARS-CoV-2 virus has affected the lives of millions of individuals globally and also severely strained the medical community.
- Trial name
- SHADE-S (NCT04952857)
- Testing
- cholecalciferol 6 lakh IU
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Respiratory Syncytial Viruses
A Study to Learn About ABRYSVO Vaccine in Older Adults to Prevent Severe Respiratory Syncytial Virus (RSV) Disease
The main purpose of this study is to learn about the effectiveness of Pfizer's ABRYSVO vaccine. This vaccine helps to prevent infections caused by Respiratory Syncytial Virus (RSV).
- Trial name
- NCT06077968
- Testing
- Prior standard of care receipt of Pfizer's ABRYSVO vaccine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Pfizer
Covid19, SARS-CoV Infection
IVIG in Patients With Severe COVID-19 Requiring Mechanical Ventilation
The purpose of this Pilot Study is to establish a hypothesis of whether or not intravenous immunoglobulin (IVIG) may impact the hospital length of stay, if started within 48 of mechanical ventilation in patients infected with…
- Trial name
- NCT04616001
- Testing
- IVIG
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sharp HealthCare
Covid19, SARS-CoV Infection
An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers
The BBV152 vaccine is being developed to prevent COVID-19, the disease resulting from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) infection.
- Trial name
- NCT04641481
- Testing
- BBV152
- Where
- India
- Volunteers
- 25,800 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
SARS-CoV Infection, Covid-19
Characterizing the Immune Response and Neuronal Damage in COVID-19
The Investigators plan to study the innate and adaptive immune response, the inflammatory response, and associated complications such as complement activation and neurological damage in SARS-Cov-2 infected individuals.
- Trial name
- NCT04510012
- Testing
- Analysis of cytokine response, innate and adaptive immune response, complement activation, and serum neurofilaments as a marker of neurological damage.
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Covid19, Infectious Disease
Policy Responses Against the COVID-19 Pandemic in Latin America
Latin America is one of the worst-hit areas from the COVID-19 pandemic worldwide. Policy responses to COVID-19 in Latin America have sought to reduce viral spread, increase the capacity of the health system response, mitigate…
- Conditions
- Covid19, Infectious Disease, Death, SARS-CoV Infection
- Trial name
- NCT04816318
- Testing
- Social and public health measures against COVID-19, Control
- Where
- Chile
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Chile
Pneumonia, Pneumocystis Carinii, HIV Infections
An Open-Label, Uncontrolled Clinical Trial of Oral 566C80 for the Treatment of Patients With Severe PCP Who Are Intolerant and/or Unresponsive to Therapy With Trimethoprim/Sulfamethoxazole and Parenteral Pentamidine
To facilitate provision of atovaquone (566C80) to patients who have severe Pneumocystis carinii pneumonia (PCP) and are intolerant and/or unresponsive to trimethoprim / sulfamethoxazole ( TMX / SMX ); to monitor serious adverse…
- Trial name
- NCT00001990
- Testing
- Atovaquone
- Where
- United States
- Sponsor
- Glaxo Wellcome
Chronic Obstructive Pulmonary Disease (COPD)
Pharmacokinetic, Safety and Tolerability Study of Aclidinium/Formoterol Fixed Dose Combination and Formoterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this Phase II study is to evaluate the pharmacokinetics, safety, and tolerability of aclidinium/formoterol fixed dose combination (FDC 400/12 μg via the Almirall Inhaler and formoterol 12 μg via the Foradil®…
- Trial name
- NCT01551888
- Testing
- Aclidinium/formoterol 400/12μg, Formoterol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Pneumonia, Bacterial
Sphingosine-1-phosphate and Pneumonia
Pneumonia is a major infectious cause of death worldwide and imposes a considerable burden on healthcare resources. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid and involved in many physiological processes including…
- Trial name
- SOPN (NCT04007328)
- Testing
- Methylprednisolone Sodium Succinate
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University WanFang Hospital
Covid19, Emergencies
Effect of Covid-19 Pandemic in Non Covid-19 Patients at the Emergency Surgical Department
Introduction Most countries imposed mandatory lockdowns that were rapidly lifted, however Argentina holds the record for one of the longest quarantines in the world.
- Conditions
- Covid19, Emergencies, Appendicitis, Surgical Procedure, Unspecified
- Trial name
- NCT04900233
- Testing
- surgery
- Where
- Argentina
- Volunteers
- 651 people
- Sponsor
- Hospital Italiano de Buenos Aires
Tracheostomy Complication, Acquired Brain Injury
Cough Assessment in Patients With Severe Acquired Brain Injury
The cough assessment is fundamental in the weaning process as it gives information on the possibility to expel food and secretion out from the airways.
- Conditions
- Tracheostomy Complication, Acquired Brain Injury, Brain Injury, Pneumonia
- Trial name
- NCT02495558
- Testing
- Reflex Cough Test
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
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