Clinical trials: Severe Sepsis
Severe Sepsis or Septic Shock in Pediatric Intensive Care Unit
Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock
Severe sepsis and septic shock remain of particular gravity in children with a current mortality of about 20 % , despite the international prevention campaigns " survival sepsis campaign ".
- Trial name
- PRECISE (NCT04027699)
- Testing
- Mini-bolus
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Sepsis
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis
Activation of caspase-4 and human caspase-5 (orthologs of caspase-11 in mice) in innate immune cells.
- Trial name
- CASPASEs (NCT02539147)
- Testing
- blood samples
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Sepsis
Mechanisms of Precise Immune Cell Phenotyping and Prognostic Prediction in Severe Infection
The goal of this observational study is to learn how changes in immune cells are linked to outcomes in adults with severe infection who are treated in the intensive care unit (ICU).
- Trial name
- PIC-PSI (NCT07332793)
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Septic Shock, Vasopressor Resistance
Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock
Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40% at 28 days.
- Trial name
- ADRESS (NCT07569536)
- Testing
- Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care
- Where
- 18 sites in France
- Volunteers
- 360 people
- Sponsor
- Hospices Civils de Lyon
Severe Sepsis
Symphony IL-6 Cutoff Establishment Study for Patients at Risk of Severe Sepsis Due to COVID-19
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05060250
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Bluejay Diagnostics, Inc.
Sepsis, Septic Shock
Health Related Quality of Life After Intensive Care for Sepsis, a National Cohort Study.
The study aims to map the health-related quality of life (HRQoL) after intensive care for Sepsis with the hypothesis that it will be lower than that in the general population.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- NCT06368336
- Volunteers
- 210,484 people
- Sponsor
- Uppsala University Hospital
Severe Sepsis
Volume Therapy With Crystalloids and Colloids and Hemodynamic Monitoring in Patients With Severe Sepsis
The primary alternative hypothesis is that less time (minutes) is required, to achieve the initial hemodynamic stabilization, with Volulyte® compared to Jonosteril®.
- Trial name
- VOMOSEP (NCT02587078)
- Testing
- Volulyte, Jonosteril
- Sponsor
- Wuerzburg University Hospital
Sepsis, Infections
Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections.
Fecal microbial transplantation is to transplant functional microbiota from the feces of healthy people into the gastrointestinal tract of patients, reconstruct new intestinal microbiota, and realize the treatment of intestinal…
- Trial name
- NCT05578196
- Testing
- fecal bacteria solution, physiological saline solution
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shanghai 10th People's Hospital
Sepsis, Severe Sepsis
The Utility of Ischemia Modified Albumin (IMA) in Sepsis
The purpose of this study is to determine if levels of ischemia modified albumin (IMA) in blood are elevated in patients with suspected infection and are predictive of severity of illness in patients with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Systemic Inflammatory Response Syndrome, Sepsis Syndrome
- Trial name
- NCT00448968
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Inverness Medical Innovations
Covid19, Sepsis
Blood Markers for Identifying & Investigating Infection With COVID19 & Sepsis in Children.
Corona Virus Disease or COVID-19 is caused by SARS-CoV-2 virus. There have been reports of serious COVID-19 illness in children. In addition it has been linked to clusters of children presenting with high fevers and inflammation.
- Trial name
- pSeP (NCT04904523)
- Testing
- Diagnostic Test:Blood test
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Cardiff University
Severe Sepsis
Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis
Cell-free hemoglobin can be measured in the plasma of patients with sickle cell anemia, hemodialysis, after red blood cell transfusion, and in patients with sepsis.
- Trial name
- ACROSS (NCT01739361)
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University
Severe Sepsis, Emergency
Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery
This study wants to compared the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in septic patients requiring emergency surgery.
- Conditions
- Severe Sepsis, Emergency, Surgery
- Trial name
- NCT01654003
- Testing
- CONTROL, OPTIMIZED
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Sepsis, Severe Sepsis
Piperacillin PK Analysis in Severe Sepsis Patients
Antibiotic dosing in septic patients poses a challenge for clinicians due to the pharmacokinetic changes seen in this population.
- Trial name
- NCT02569086
- Testing
- Blood draw
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Severe Sepsis
Efficacy of Thymosin alpha1 for Severe Sepsis
The purpose of this study is to evaluate the efficacy of thymosin alpha 1 for treating severe sepsis.
- Trial name
- ETASS (NCT00711620)
- Testing
- Thymosin alpha 1
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Sun Yat-sen University
Severe Sepsis
Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation.
This study aims to assess the effect of acute inflammation on arterial stiffness and microcirculation. Patients with severe sepsis will be compared with age-, sex- and cardiovascular risk factors-matched controls.
- Trial name
- IRIGA (NCT01556373)
- Testing
- NA : non interventional study
- Where
- 2 sites in France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Septic Shock, Ascorbic Acid Deficiency
Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.
This is a retrospective chart review that will measure the impact on outcomes in septic shock patients who were resuscitated with a novel combination of medicines called iHAT (intravenous hydrocortisone -ascorbic acid-thiamine).
- Trial name
- NCT03913468
- Testing
- Intravenous Ascorbic Acid
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Wisconsin, Madison