Clinical trials: Severe Septic Syndrome
Pancreatic Neoplasms, Urogenital Neoplasm
The Importance of Albumin Infusion Rate for Plasma Volume Expansion Following Major Abdominal Surgery
To study if plasma volume expansion is influenced by the rate at which a colloidal solution is administered in patients with a systemic inflammatory response induced by major abdominal surgery.
- Conditions
- Pancreatic Neoplasms, Urogenital Neoplasm, Systemic Inflammatory Response Syndrome, Hypovolemia
- Trial name
- AIR (NCT02728921)
- Testing
- 5% Albumin infusion 30 min, 5% Albumin infusion 3 hours
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Region Skane
Sepsis, Sepsis, Severe
Does the Phoenix Pediatric Sepsis Prognosis Prediction Scale Work
The aim of this study to understand the compatibility of Phoenix Score, International 2005 SIRS criterias and PRISM III, PELOD scoring systems.
- Trial name
- NCT06539884
- Testing
- Observational
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Oguz Dursun
Sepsis
HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis
Molecules indicating endothelial injury may serve as biomarkers for severe sepsis because of the critical role of endothelial injury in organ dysfunction during severe sepsis.
- Trial name
- NCT01847248
- Where
- China
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Severe Sepsis
The Efficacy of Si-Ni-Tang (a Chinese Herbal Formula) for Severe Sepsis
The purpose of this study is to evaluate the efficacy of Si-Ni-Tang (a Chinese Herbal Formula documented in Shang Han Lun) in treating severe sepsis.
- Trial name
- NCT02777606
- Testing
- Si-Ni-Tang
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Sepsis, Respiratory Failure
Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure
Patients with infections in their blood often become very sick. These patients are usually put in an intensive care unit for careful observation and treatment.
- Conditions
- Sepsis, Respiratory Failure, Agitation
- Trial name
- PRO-DEFENSE (NCT02203019)
- Testing
- Propofol, Dexmedetomidine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Texas Tech University Health Sciences Center
Sepsis, Severe Sepsis
Inferior Vena Cava Collapsibility Index in Severe Sepsis
There is debate regarding the use of non invasive (ultrasound assessed) parameters of fluid volume status in patients with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02195830
- Testing
- Ultrasound of the inferior vena cava
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- Teesside University
Coronavirus Infection, Sepsis
Annexin A5 in Patients With Severe COVID-19 Disease
Randomized, double-blind, placebo-controlled trial comparing 2 doses of SY-005 (recombinant human Annexin A5) to placebo in patients with severe coronavirus 2019 disease in a single hospital centre with 2 intensive care units
- Trial name
- AX-COVID (NCT04748757)
- Testing
- recombinant human annexin A5
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Multiple Organ Dysfunction With Severe Endotoxemia
Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)
Sepsis is a state of multiple organ dysfunction caused by a generalized immune-inflammatory response of the body to an infectious agent, with pronounced heterogeneity and interchangeability of clinical and laboratory…
- Trial name
- РМХ vs SS (NCT04920565)
- Testing
- hemoperfusion with polymyxin B
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Severe Sepsis or Septic Shock
Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?
Many biomarkers have been evaluated in sepsis, especially for prognostic purposes, but none has yet been shown to have sufficient sensitivity or specificity for routine use in clinical practice.
- Trial name
- HEP-SEPSIS (NCT03682003)
- Testing
- blood diagnostic tests
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Rennes University Hospital
Pancreatectomy, Pancreatic Surgery
PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery
This study examines a new blood test called ICIS, which may help detect infections earlier after pancreatic surgery. Patients will have routine blood samples taken during their hospital stay, with no extra procedures required.
- Conditions
- Pancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers
- Trial name
- PAN-ICIS (NCT07248527)
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Charles University, Czech Republic
Sepsis, Severe Sepsis
The AVERT Sepsis Investigation
The overall objective of this study is to utilize heart rate variability and respiratory rate variability in patients with sepsis to predict clinical deterioration and death. Our specific objectives are: 1.
- Trial name
- AVERT (NCT01968746)
- Where
- 5 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Christiana Care Health Services
Severe Sepsis
Pharmacokinetics, Safety, Tolerability and Pharmacodynamics of BMS-986189 in Healthy Subjects
The main purpose of this study is to measure the amount of study drug (BMS-986189) in the blood and urine and to see if BMS-986189 is safe and well-tolerated in healthy people after a single dose.
- Trial name
- NCT02739373
- Testing
- BMS-986189
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Pneumonia, Diarrhea
Impact of Daily Zinc Supplementation to Infants Born With Low Birth Weight on Death and Severe Disease
Title: Impact of daily zinc supplementation to infants born with low birth weight on mortality and severe disease requiring hospitalization Background: Zinc supplementation was shown to prevent diarrhea and pneumonia in 6 month…
- Conditions
- Pneumonia, Diarrhea, Meningitis, Sepsis
- Trial name
- NCT00495690
- Testing
- Oral zinc gluconate (5 mg elemental)
- Where
- India
- Volunteers
- 2,012 people
- Sponsor
- Society for Applied Studies
Severe Sepsis
Therapeutic Effect of Sodium Selenite on Oxidative Stress in Patients With Severe Sepsis
This study looked at parenteral administration of selenium to septic patients and subsequently monitored dynamic changes of selected activities of antioxidant enzymes and the development of clinical status.
- Trial name
- Se-AOX (NCT02026856)
- Testing
- sodium selenite pentahydrate
- Where
- Slovakia
- Volunteers
- 4 people
- Sponsor
- Pavol Jozef Safarik University
Sepsis, Shock, Septic
Sepsis Assessment in Belgian Emergency Rooms
To validate the use of the Heparin Binding Protein (HBP) concentration to assist in the evaluation of patients admitting to the emergency department with suspected infection.
- Conditions
- Sepsis, Shock, Septic, Severe Sepsis
- Trial name
- SABER (NCT02424721)
- Where
- 4 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Axis Shield Diagnostics Ltd
Septicemia
Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)
The purpose of this study is to determine whether immunoadsorption of LPS, Il-6 and C5a reduces systemic hyperinflammation, improves immune function and improves organ function in patients with severe sepsis and septic shock
- Trial name
- NCT00146432
- Testing
- Immunoadsorption of LPS, IL-6 and C5a
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Sepsis
IgM-enriched Immunoglobulin Attenuates Systemic Endotoxin Activity in Early Severe Sepsis
The purpose of this study is to evaluate the effect of IgM-enriched immunoglobulins (Pentaglobin) on the endotoxin activity, conventional coagulation parameters, viscoelastic and aggregometric measurements of patients with severe…
- Trial name
- NCT02444871
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Goethe University
Severe Sepsis, Septic Shock
A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock
The primary purpose of this study to evaluate the effect of two different doses of AZD9773 (CytoFab™) versus placebo on ventilator free days (VFDs) over the first 28 days after the start of dosing with AZD9773 in patients with…
- Trial name
- NCT01145560
- Testing
- AZD9773
- Where
- 52 sites in Australia, Belgium and 5 more
- Volunteers
- 300 people
- Sponsor
- AstraZeneca