Clinical trials: Severe Septic Syndrome
Severe Sepsis
End-of-life Decision-making in Patients With Sepsis-related Organ Failure
The care of patients with sepsis-related organ failure on the intensive care unit (ICU) often includes end-of-life decision (EOL-D) and communication of such decisions to relatives.
- Trial name
- EIDECS (NCT01247792)
- Testing
- SOPs for decision-making and communication
- Where
- Germany
- Volunteers
- 174 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Sepsis, Postoperative Complications
Risk Factors Identification of Sepsis and Septic Shock After Major Abdominal Surgery Based on Artificial Intelligence
The goal of this observational study is to identify the risk factors and build the early warning system of sepsis and septic shock after major abdominal surgery based on artificial intelligence.
- Trial name
- NCT06684340
- Testing
- Exposure to major abdominal surgery
- Volunteers
- 22,646 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Sepsis, Severe Sepsis
Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's)
This is a randomized controlled trial comparing standard-of-care therapy of infections in critically ill patients with a procalcitonin-guided approach evaluating efficacy (antibiotics consumption) and safety (mortality).
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- SAPS (NCT01139489)
- Testing
- procalcitonin-guidance
- Where
- Netherlands
- Volunteers
- 1,575 people
- Sponsor
- Amsterdam UMC, location VUmc
ARDS, Septic Shock
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation
to evaluate the effect of use of bronchoscopy in the course of sepsis, weaning from the ventilator, duration of ICU stays and mortality rate in septic patients with ARDS due to VAP.
- Trial name
- NCT06072248
- Testing
- Meropenem, bronchoscopy, ventilator
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Severe Sepsis, Septic Shock
(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis
This prospective randomized multicenter study evaluates whether the decision to prescribe antifungals guided by (1,3)-β-D-glucan in comparison to standard of care shortens time to antifungal therapy and reduces mortality in…
- Trial name
- CandiSep (NCT02734550)
- Testing
- Standard of care, (1,3)-β-D-glucan guided therapy
- Where
- 18 sites in Germany
- Volunteers
- 342 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Severe Sepsis, Cardiac Arrest
Examination of the Impact of Better Surveillance and Communication of Patient Deterioration on Patient Related Outcomes
A hospitals manual method of patient monitoring will be implemented in an automated system and supported by an early patient deterioration detection for timely escalation.
- Conditions
- Severe Sepsis, Cardiac Arrest, Respiratory Failure
- Trial name
- NCT01692847
- Where
- United Kingdom
- Volunteers
- 678 people
- Sponsor
- Philips Healthcare
Bacteremia, Bacteremia Sepsis
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
This project will evaluate the usefulness of Monocyte Distribution Width (MDW) for the diagnosis of blood culture positivity (BSI) in patients in the Emergency Department (ED) and reevaluate the usefulness of MDW in patients with…
- Conditions
- Bacteremia, Bacteremia Sepsis, Sepsis, Septic Shock
- Trial name
- NCT05296590
- Testing
- Monocyte Distribution Width (MDW) , observation
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Henry Ford Health System
Severe Sepsis
Evaluation of MorphoTEP With the FDG Among Patients in Severe Sepsis of Unspecified Etiology
The objective of this pilot study is to estimate a procedure where the biological samples routinely obtained at the site of suspected infection could be guided by the early realization of a TEP with FDG coupled to scanner X, in…
- Trial name
- NCT00791310
- Testing
- Flucis
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis, Severe, Septic Shock
Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock
In recent years, many studies have pointed out that bacterial toxin and cytokine storm are the main causes of shock and multiple organ failure in patients with sepsis.
- Trial name
- NCT03974386
- Testing
- oXiris blood purification set
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Severe Sepsis
An Open Label Study of Severe Sepsis in Adults
This trial is to obtain safety data in adult patients with severe sepsis and two sepsis-induced organ infections who receive an infusion of drotrecogin alfa (activated).
- Trial name
- NCT00568893
- Testing
- drotrecogin alfa (activated)
- Where
- 18 sites in Belgium
- Volunteers
- 130 people
- Sponsor
- Eli Lilly and Company
Systemic Inflammatory Response Syndrome
Can Biomarkers Aid in the Prediction of Postoperative Pain and Circulatory Instability After Major Abdominal Surgery?
Patients undergoing major surgery are exposed to extensive damage of tissues, which induces widespread activation of the inflammatory system, called 'systemic inflammatory response syndrome' (SIRS).This activation of the…
- Trial name
- NCT02563652
- Where
- 2 sites in Italy, Norway
- Volunteers
- 101 people
- Sponsor
- St. Olavs Hospital
COVID
Colchicine in Patients With Mild and Severe Coronavirus Disease
The world is currently facing a pandemic due to the outbreak of a new coronavirus causing acute respiratory failure called SARS-Cov2.
- Trial name
- ColchiVID (NCT04367168)
- Testing
- Colchicine
- Where
- Mexico
- Volunteers
- 116 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Death, Severe Sepsis
Sepsis Institutional Registry in Hospital Italiano de Buenos Aires
The purpose of this study is to create an institutional registry of sepsis through a prospective survey based on epidemiological data, risk factors, diagnosis, prognosis, treatment, monitoring and survival.
- Trial name
- SIR (NCT01403935)
- Where
- Argentina
- Volunteers
- 7,472 people
- Sponsor
- Hospital Italiano de Buenos Aires
Severe Sepsis
A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.
A study to evaluate the safety, tolerability and pharmacokinetics of Nivolumab in participants with severe sepsis or septic shock.
- Trial name
- NCT02960854
- Testing
- Nivolumab
- Where
- 16 sites in United States
- Volunteers
- 38 people
- Sponsor
- Bristol-Myers Squibb
Severe Sepsis or Septic Shock
Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis
Observational studies among critically ill patients have shown strong associations between vitamin D deficiency and adverse outcomes, including increased length of stay, infection, and mortality.
- Trial name
- NCT01689441
- Testing
- Calcitriol
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Brigham and Women's Hospital
Sepsis
Epidemiology of Sepsis in China
Sepsis is a common cause for morbidity and mortality in critically ill patients. In USA, the incidence of sepsis is about 3/1000 population. However, the incidence of sepsis varies among different clinic trails.
- Trial name
- NCT02448472
- Testing
- Observational study, none intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Jianfeng Xie
Sepsis
A Phase IIb Study to Determine the Efficacy and Safety of the Study Drug in Patients With Severe Sepsis
The purpose of this study is to determine whether the administration of the study drug is effective in increasing the chance of survival in patients with severe sepsis.
- Trial name
- NCT00034476
- Testing
- sPLA2 Inhibitor
- Where
- 85 sites in United States, Belgium and 3 more
- Volunteers
- 466 people
- Sponsor
- Eli Lilly and Company
Sepsis
High Dose Intravenous Ascorbic Acid in Severe Sepsis
Despite an organized treatment approach outlined in expert-consensus guidelines for sepsis with fluid resuscitation to treat hypovolemia, antibiotics to target the infectious insult, and vasopressors for hypotension, mortality…
- Trial name
- NCT02734147
- Testing
- Ascorbic Acid, Normal Saline
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Christiana Care Health Services
Septic Shock, Sepsis
Fluid Resuscitation in Early Septic Shock
Severe infection in the intensive care unit is common accounting for about 10% of admissions and has a death rate of approximately 40-50%. It is almost always associated with significant reductions in blood pressure.
- Conditions
- Septic Shock, Sepsis, Severe Sepsis
- Trial name
- PRECISE (NCT00819416)
- Testing
- 5% albumin, Normal Saline
- Where
- 6 sites in Canada
- Volunteers
- 47 people
- Sponsor
- Ottawa Hospital Research Institute
SIRS, Sepsis
NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
The purpose of this study is to determine the course of NT-proBNP plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- SIRS, Sepsis, Shock, Critically Ill
- Trial name
- NICUPS (NCT00736723)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm