Clinical trials: Severe Septic Syndrome
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Septic Shock, Ascorbic Acid Deficiency
Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.
This is a retrospective chart review that will measure the impact on outcomes in septic shock patients who were resuscitated with a novel combination of medicines called iHAT (intravenous hydrocortisone -ascorbic acid-thiamine).
- Trial name
- NCT03913468
- Testing
- Intravenous Ascorbic Acid
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Wisconsin, Madison
Septic Shock, Severe Sepsis
Restrictive Intravenous Fluids Trial in Sepsis
IV fluid resuscitation has long been recognized to be an important treatment for patients with severe sepsis and septic shock. While under-resuscitation is known to increase morbidity and mortality, contemporary data suggests…
- Trial name
- RIFTS (NCT03137446)
- Testing
- Intravenous Fluid Cap
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Rhode Island Hospital
Sepsis, Severe, Septic Shock
Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.
This study has been created to compare the addition of intravenous (IV) vitamin C, thiamine, and hydrocortisone to the usual standard of care of sepsis and septic shock.
- Trial name
- ORANGES (NCT03422159)
- Testing
- Ascorbic Acid, Thiamine, Hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Community Medical Center, Toms River, NJ
Sepsis, Severe Sepsis
Prehospital Antibiotics Against Sepsis Trial
Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. The incidence of sepsis is likely to rise in the upcoming years.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PHANTASi (NCT01988428)
- Testing
- Ceftriaxone 2000 mg
- Where
- 34 sites in Netherlands
- Volunteers
- 2,672 people
- Sponsor
- Amsterdam UMC, location VUmc
Severe COVID-19 Disease
RAPA-501-Allo Therapy of COVID-19-ARDS
The first-in-human Phase 1 study component will evaluate two dose levels of RAPA-501-ALLO off the shelf cells in patients with COVID-19-related ARDS, with key endpoints of safety, biologic and potential disease-modifying effects.
- Trial name
- NCT04482699
- Testing
- RAPA-501-Allo off-the-shelf Therapy of COVID-19
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rapa Therapeutics LLC
Severe Sepsis
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis
Activation of caspase-4 and human caspase-5 (orthologs of caspase-11 in mice) in innate immune cells.
- Trial name
- CASPASEs (NCT02539147)
- Testing
- blood samples
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Severe Sepsis
Pro-inflammatory Cytokines Profile and Mortality Rate of Critically Ill Septic Patients Following Plasmapheresis
Sepsis is one of the most prevalent and fatal diseases in intensive care units .unfortunately, therapeutic approach to sepsis has remained unchanged for many years.
- Trial name
- NCT01249222
- Testing
- plasmapheresis
- Where
- Iran
- Volunteers
- 27 people
- Sponsor
- Tehran University of Medical Sciences
Sepsis, Severe
Early Administration of Norepinephrine in Sepsis
The management of septic states includes, in addition to the specific treatment (antimicrobials and eradication of the source), a restoration of the hemodynamic disorders and assistance of the failing organs.
- Trial name
- EA-NE-TUN (NCT05836272)
- Testing
- Norepinephrine Bitartrate
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Tunis University
Shock, Surgical, Systemic Inflammatory Response Syndrome
Thromboelastography in in Patients With Sepsis
Methods: The study is an observational prospective trial that includes 150 patients 18 or older admitted to our icu because of severe sepsis or septic shock as defined by the American College of Chest Physicians/ Society of…
- Trial name
- NCT00994877
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Severe Sepsis
Clinical Assessment of Fish Oil-based Lipid Emulsion Infusions in Critical Patients With Severe Sepsis
The purpose of this study is to determine whether a fish oil-based lipid emulsion, enriched with ω-3 fatty acids, reduce proinflammatory cytokines and mortality rate in critically ill patients with severe sepsis.
- Trial name
- NCT00634075
- Testing
- omega-3-fatty acids (Omegaven)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Li Shin Hospital
Sepsis, Septic Shock
Vitamin C & Thiamine to Treat Sepsis and Septic Shock
Investigators propose to investigate the use of IV vitamins B1 and C in a randomized, double-blinded, prospective trial to determine if these medications decrease mortality rates in patients with severe sepsis or septic shock.
- Trial name
- NCT03592277
- Testing
- Vitamin C, Vitamin B1
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Trinity Health Of New England
Sepsis, Severe Sepsis
BaSES Trial: Basel Starch Evaluation in Sepsis
Background: In patients with severe sepsis and septic shock early aggressive volume replacement reduced mortality. Standard infusion therapy consists of crystalloid infusions.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- BaSES (NCT00273728)
- Testing
- hydroxy-ethyl starch (MW 130; 0.4) vs. normal saline
- Where
- 2 sites in Switzerland
- Volunteers
- 231 people
- Sponsor
- University Hospital, Basel, Switzerland
Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit
Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock
The purpose of this study is to determine whether an aggressive strategy of severe sepsis patients since pre hospital care, including early antibiotics administration, hemodynamic optimization, and opotherapy when indicated…
- Trial name
- SSS (NCT02473263)
- Testing
- Ceftriaxone, Piperacillin tazobactam, Norepinephrine
- Where
- France
- Volunteers
- 398 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Severe Sepsis and Septic Shock
Evaluation of CPD MNV as an Aid in the Diagnosis and Risk Assessment of Sepsis (Protocol # Sepsis 1-14)
The investigators hypothesize that CPD parameters will provide improved prediction of sepsis compared to currently employed laboratory parameters.
- Trial name
- Beckman (NCT02232750)
- Where
- United States
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Severe Sepsis, Septic Shock
Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa
The purpose of this study is to compare the tendency of plasma concentration and clearance of procalcitonin in the first 24 and 48 hours of management of patients with severe sepsis and septic shock with another marker of early…
- Trial name
- NCT01841190
- Where
- 2 sites in Brazil
- Volunteers
- 128 people
- Sponsor
- Hospital Sao Domingos
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Severe Sepsis
Platelet-associated Inflammation in Severe Sepsis
Sepsis represents a serious public health issue characterized by a complex inflammatory response. In addition to their hemostatic role, platelets display inflammatory functions by secreting a variety of immunomodulatory factors…
- Trial name
- PlatISSep (NCT03029039)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sepsis, Severe Sepsis
ED Tracking Sheet Implementation
The purpose of this study is to assess whether implementation of an ED Sepsis Tracking Sheet effects the percentage of goal-directed sepsis criteria met in a tertiary care academic Emergency Department.
- Conditions
- Sepsis, Severe Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT05213923
- Testing
- ED Sepsis Tracking Sheet
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Sepsis, Sepsis Syndrome
Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance
Sepsis is a condition with a high mortality. Septic patients are frequently difficult to identify because of their non-specific presentations.
- Conditions
- Sepsis, Sepsis Syndrome, Sepsis, Severe
- Trial name
- NCT03249597
- Testing
- Blood test: Glukos, SuPAR, Laktat and HBP
- Where
- Sweden
- Volunteers
- 956 people
- Sponsor
- Karolinska Institutet