Clinical trials: Severe Septic Syndrome
Severe Sepsis
High Flow Nasal Cannula in Severe Sepsis
Severe sepsis leads a high morbidity and mortality by causing organ damage at distance. The treatment relies on early antibiotic therapy and hemodynamic resuscitation.
- Trial name
- OPTISEPSIS (NCT03334227)
- Testing
- High-Flow nasal cannula (HFNC)
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Shock, Surgical, Systemic Inflammatory Response Syndrome
Thromboelastography in in Patients With Sepsis
Methods: The study is an observational prospective trial that includes 150 patients 18 or older admitted to our icu because of severe sepsis or septic shock as defined by the American College of Chest Physicians/ Society of…
- Trial name
- NCT00994877
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Sepsis
Epidemiology of Sepsis at Yuetan Subdistrict in Beijing
The purpose of this study is to determine the epidemiology and outcome of sepsis at Yuetan subdistrict in Beijing in mainland China).
- Trial name
- NCT02285257
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis, Shock, Septic
Early Identification of Sepsis in Children
This observational nation-wide study is focused on evaluation of the new possible biomarkers for pediatric sepsis and their specificity/sensitivity in combination with usual diagnostic markers for sepsis in the terms of early…
- Conditions
- Sepsis, Shock, Septic, Sepsis, Severe, SIRS
- Trial name
- NCT03884595
- Testing
- IG, IPF, NRBC, CRP, PCT, presepsin
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Severe Infection
Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) in Obstetric Patients
Research problem: In 1991, the terms Systemic Inflammatory Response Syndrome (SIRS), severe sepsis, and septic shock were introduced, based on the pro-inflammatory theory, conforming to a list of classification criteria for each…
- Trial name
- COLOSSAL (NCT04621539)
- Where
- Colombia
- Volunteers
- 2,125 people
- Sponsor
- Fundación Grupo de Investigación en Cuidados Intensivos y Obstetricia
Critical Illness, Severe Sepsis
A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children
1. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infection in children in different regions of China. 2.
- Trial name
- NCT04955210
- Testing
- Not applicable（Cohort study）
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital of Fudan University
Death, Severe Sepsis
Sepsis Institutional Registry in Hospital Italiano de Buenos Aires
The purpose of this study is to create an institutional registry of sepsis through a prospective survey based on epidemiological data, risk factors, diagnosis, prognosis, treatment, monitoring and survival.
- Trial name
- SIR (NCT01403935)
- Where
- Argentina
- Volunteers
- 7,472 people
- Sponsor
- Hospital Italiano de Buenos Aires
Pseudomonas Infections, Pseudomonas Septicemia
Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in…
- Conditions
- Pseudomonas Infections, Pseudomonas Septicemia, Pseudomonas; Pneumonia, Pseudomonal Bacteraemia
- Trial name
- MIPSA (NCT03044223)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Cancer, Septic Shock
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
Retrospective study to evaluate the characteristics of patients and of fluid resuscitation during intensive care unit hospitalization of patients under septic chock.
- Conditions
- Cancer, Septic Shock, Other Fluid Overload
- Trial name
- NCT01304680
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer
Shock, Septic
Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis and Septic Shock
The impact of lactate guided therapy on septic shock has not been extensively investigated, however the goal directed therapy has been used for years.
- Trial name
- NCT01310790
- Testing
- lactate group:lactate acide clearance directed group; ScvO2 group:ScvO2 directed group;control group
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Chinese Septic Shock Network
Sepsis-Associated Encephalopathy
Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy
Septic encephalopathy (SE) is defined as acute cerebral dysfunction in patients with sepsis or septic shock. SE occurs in up to 50% of critically ill patients with sepsis and is associated with a high mortality and morbidity.
- Trial name
- ADVISE (NCT04076826)
- Testing
- Dexmedetomidine, Propofol or Midazolam, Blood sampling
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sepsis, Septic Shock
The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients
Surgical trauma elicits an immune response aiming to initiate healing and remove debris and damaged tissue locally at the wound site (1).
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Post-Op Complication
- Trial name
- NCT04117568
- Testing
- Blood sampling
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Göteborg University
Severe Sepsis, Septic Shock
Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation
The purpose of this study is to determine if there is equivalence between two different methods of treating patients with severe bloodstream infection called sepsis.
- Trial name
- LactATES (NCT00372502)
- Testing
- Modified EGDT, Standard EGDT
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Severe Sepsis, Septic Shock
Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis
The purpose of this study is to determine whether BMS-936559 is safe and has the desired pharmacologic activity in patients who have severe sepsis.
- Trial name
- NCT02576457
- Testing
- BMS-936559
- Where
- 13 sites in United States
- Volunteers
- 35 people
- Sponsor
- Bristol-Myers Squibb
COVID-19, Acute Respiratory Distress Syndrome
Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19
Ideal new treatments for Novel Coronavirus-19 (COVID-19) would help halt the progression disease in patients with mild disease prior to the need for artificial respiration (ventilators), and also provide a rescue treatment for…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Severe Acute Respiratory Syndrome (SARS), Coronavirus Infections
- Trial name
- SINK COVID-19 (NCT04365985)
- Testing
- Naltrexone, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Corewell Health East
Sepsis
The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients With Severe Sepsis
Severe sepsis is defined as a systemic inflammatory response syndrome that results from infection and is associated with acute organ dysfunction.
- Trial name
- NCT00045760
- Testing
- Drotrecogin alfa (activated)
- Where
- 426 sites in United States, Australia and 30 more
- Sponsor
- Eli Lilly and Company
Trauma Injury, Major Abdominal Surgery
Bolus Versus Continuous Enteral Tube Feeding
Stress metabolisms induced by severe trauma, large abdominal surgery procedures, sepsis, etc. leads to metabolic changes, which increase energy expenditure, enhanced protein catabolism, insulin resistance.
- Conditions
- Trauma Injury, Major Abdominal Surgery, Sepsis
- Trial name
- NCT04080479
- Testing
- Quadriceps Muscle Layer Fitness, Muscle Strength, Acute Physiology and Chronic Health Evaluation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Trauma, Inflammation
Transcriptomic Profiling in Severely Injured Patients
Discovery of differences in the host response in patients with systemic inflammation and sepsis, and identification of novel, specific markers by using a longitudinal clinico-transcriptomic approach.
- Conditions
- Trauma, Inflammation, Sepsis
- Trial name
- NCT02508272
- Where
- Switzerland
- Volunteers
- 115 people
- Sponsor
- University of Zurich
Neutropenia, Fever
Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia
The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.
- Conditions
- Neutropenia, Fever, Bacterial Infection, Fungal Infection
- Trial name
- NCT02544230
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne
Severe Sepsis
ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis
The purpose of this study is to compare eritoran tetrasodium and placebo in patients with severe sepsis and to demonstrate a reduction of mortality from all causes.
- Trial name
- NCT00334828
- Testing
- eritoran tetrasodium
- Where
- 251 sites in United States, Argentina and 22 more
- Volunteers
- 2,000 people
- Sponsor
- Eisai Inc.