Clinical trials: Severe Septic Syndrome
Multiple Organ Failure, Septic Shock
Early Metabolic Resuscitation for Septic Shock
This phase II trial studies how well early metabolic resuscitation therapy works in reducing multi-organ dysfunction in patients with septic shock.
- Conditions
- Multiple Organ Failure, Septic Shock, Severe Sepsis
- Trial name
- NCT03895853
- Testing
- Best Practice, early metabolic resuscitation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Encephalopathy, Organ Dysfunction Syndrome
Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG
The patients of the group "sepsis" are measured several times with the non-invasive multi-spectral sonography (Sonovum "ACG-Diagnosesystem") (days 1, 3, 7 and 14).
- Trial name
- SAEACG (NCT03173196)
- Testing
- Non-invasive Multispectral Sonography
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Rostock
Acute Kidney Injury, Septic Shock
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and is associated with a high mortality rate. Currently there is no available specific treatment to prevent or treat AKI in this setting.
- Conditions
- Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality
- Trial name
- VITAKI (NCT04589546)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Severe Sepsis With Septic Shock, Lactate Blood Increase
Saving Lives by Early Detection and Treatment of Sepsis and Septic Shock by Point of Care Lactate Test in Adults
Burden: The global burden of sepsis is difficult to ascertain, although a recent scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for…
- Trial name
- POCLactate (NCT05108467)
- Testing
- Point of care Lactate
- Where
- Bangladesh
- Volunteers
- 80 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Sepsis, Severe Sepsis
Control of Fever in Septic Patients
The benefits of fever treatment in critically ill patients remains unclear. The aim of the prospective, randomized clinical trial was to verify the hypothesis that the administration of ibuprofen in order to decrease the fever in…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- COVERSEP (NCT04227652)
- Testing
- Ibuprofen administration
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Ostrava
Severe Sepsis, Microcirculation
Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis
The purpose of this study is to asses the recovery of organ failure between two resuscitation protocols in severe sepsis: standard, pressure guided therapy versus a microcirculation guided therapy
- Trial name
- NCT00484133
- Testing
- Dopamine, dobutamine, enoximone
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Severe Sepsis, Septic Shock
Activated Protein C and Microcirculation
Objective: to test the hypothesis that recombinant activated protein C (aPC) therapy improves the microcirculation of severe septic patients. Design: Prospective, open study. Setting: University 12-beds intensive care unit.
- Trial name
- NCT01806428
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Università Politecnica delle Marche
Sepsis, Severe Sepsis With Septic Shock
Wearable Sweat Sensor for High-Concentration Lactate Monitoring in Critically Ill Patients
Blood lactate level is closely associated with the prognosis of patients with sepsis and septic shock. Clinical guidelines explicitly recommend blood lactate monitoring in septic patients and lactate-guided fluid resuscitation…
- Conditions
- Sepsis, Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
- Trial name
- NCT07716371
- Testing
- High-Concentration Sweat Lactate Wearable Monitoring Device, Commercial Sweat Collection Device (HELA)
- Volunteers
- 86 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Sepsis, Severe
Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy
Evaluation of a novel therapy approach for severe sepsis patients. Subjects randomized into the treatment arm receive treatment with an immune cell perfusion system on top of standard care.
- Trial name
- ReActiF-ICE (NCT05442710)
- Testing
- ARTICE
- Where
- 20 sites in Germany
- Volunteers
- 142 people
- Sponsor
- Artcline GmbH
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Septic Shock
Membrane Shedding During Septic Shock
Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and…
- Trial name
- NCT01604551
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Pneumonia
Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia
We hypothesize that serial changes of body composition in patients with pneumonia can help clinician to monitor prognosis. It was associated with underlying immune response.
- Trial name
- NCT04396522
- Testing
- noninvasively Bio-electrical Impedance Analysis (BIA)
- Where
- Taiwan
- Volunteers
- 194 people
- Sponsor
- Chang Gung Memorial Hospital
Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma
NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19)
The NexCAR19 study is a national, open-label, multicenter Phase 2-3 clinical trial designed to evaluate the efficacy and safety of the anti-CD19 chimeric antigen receptor (CAR) T-cell product, Talikabtagene Autoleucel, in…
- Conditions
- Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma (DLBCL), High-grade B-cell Lymphoma (HGBCL)
- Trial name
- NexCAR19 (NCT07502118)
- Testing
- Talikabtagene Autoleucel
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Health Institutes of Turkey
Pneumonia, Sepsis
Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting Diseases and Immunosuppression
Pneumonia is a common infectious disease of the lung, often requiring treatment in the hospital. Clinical scoring systems are available, identifying patients not requiring hospitalization.
- Conditions
- Pneumonia, Sepsis, Shock, Septic
- Trial name
- PROGRESSCOMORB (NCT05688774)
- Where
- 10 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps
Anesthesia, Endothelial Dysfunction
Effect of Fluid Challenge on Glycocalyx
Interventional study comparing effect of two regimes of fluid challenge in patients with sepsis and in patients undergoing elective major surgery on glycocalyx by using perfused Boundary Region in sublingual microcirculation.
- Conditions
- Anesthesia, Endothelial Dysfunction, Sepsis, Septic Shock
- Trial name
- NCT03891342
- Testing
- Fluid bolus administration
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Hradec Kralove
Sepsis
Mild Therapeutic Hypothermia During Severe Sepsis
Objectives: to evaluate the feasibility, the safety and the effects on physiological parameters of mild therapeutic hypothermia during septic shock. Design: a randomized, controlled, pilot physiological study.
- Trial name
- NCT01069146
- Testing
- Mild therapeutic hypothermia induction
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Severe Sepsis, Septic Shock
(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis
This prospective randomized multicenter study evaluates whether the decision to prescribe antifungals guided by (1,3)-β-D-glucan in comparison to standard of care shortens time to antifungal therapy and reduces mortality in…
- Trial name
- CandiSep (NCT02734550)
- Testing
- Standard of care, (1,3)-β-D-glucan guided therapy
- Where
- 18 sites in Germany
- Volunteers
- 342 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sepsis, Severe Sepsis
The AVERT Sepsis Investigation
The overall objective of this study is to utilize heart rate variability and respiratory rate variability in patients with sepsis to predict clinical deterioration and death. Our specific objectives are: 1.
- Trial name
- AVERT (NCT01968746)
- Where
- 5 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Christiana Care Health Services
Severe Sepsis, Septic Shock
Echo vs. EGDT in Severe Sepsis and Septic Shock
Echocardiography (cardiac ultrasound) is being used more often in the critical care setting for management of severe infection (septic shock).
- Trial name
- ECHO RCT (NCT02354742)
- Testing
- Echo guided fluid resuscitation, EGDT fluid resuscitation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Intermountain Health Care, Inc.