Clinical trials: Severe Septic Syndrome
Septic Shock, Multiple Organ Failure
Severe Sepsis/Septic Shock on Admission to the General Surgical ICU
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation may help improving survival and outcome especially the…
- Conditions
- Septic Shock, Multiple Organ Failure, Fatal Outcome
- Trial name
- NCT01363635
- Where
- Thailand
- Volunteers
- 800 people
- Sponsor
- Mahidol University
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
Burn
Microbiota in Children With Severe Burn Injury
The research protocol consists of taking aliquots of biological specimens from skin swabs, nasopharyngeal swabs, and fecal swabs.
- Trial name
- MIBUS (NCT07098377)
- Testing
- nasopharyngeal swab for biological sample analysis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Septic Shock, Severe Sepsis
Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock
Catecholamines infusion is a major component of septic shock management. International guidelines recommend that norepinephrine should be preferred to epinephrine, though phase III trials are lacking.
- Conditions
- Septic Shock, Severe Sepsis, Infections
- Trial name
- CATS (NCT00148278)
- Testing
- norepinephrine and dobutamine
- Where
- 15 sites in France
- Volunteers
- 330 people
- Sponsor
- University of Versailles
Sepsis, Severe
Vitamin C, Vitamin B1 and Steroid in Sepsis
A randomized controlled trial to test the synergic modulation effect of vitamin C, thiamine and hydrocortisone in patients with severe sepsis or septic shock.
- Trial name
- NCT04039815
- Testing
- Ascorbic acid-Vitamin B1-Hydrocortisone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far Eastern Memorial Hospital
B-Acute Lymphoblastic Leukemia, CAR-T Cell Therapy
Pre-emptive Anakinra for Cytokine Event Reduction
Objectives: The primary objective of this study will be to evaluate the impact of pre-emptive use of anakinra on the rate of severe cytokine release syndrome (CRS) following CD19-directed chimeric antigen receptor (CAR) T-cell…
- Conditions
- B-Acute Lymphoblastic Leukemia, CAR-T Cell Therapy, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity Syndrome
- Trial name
- PACER (NCT06703216)
- Testing
- Anakinra (Kineret®)
- Where
- United States
- Sponsor
- Kevin McNerney
Severe Sepsis
Descriptive Study of the Evolution in Proportion of Regulatory B Lymphocytes in Patients Hospitalized in Intensive Care for Severe Sepsis
Severe sepsis and septic shock are the most severe forms of sepsis (which associates a systemic inflammatory response with infection).
- Trial name
- DELyBREG (NCT03115125)
- Testing
- Describe for the first time the kinetics of evolution in proportion of the circulating Brég in patients with severe septic state, at times D0, D2, D7 and D14 of hospitalization in medical reanimation.
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Burns, Multiple Organ Failure
Early Haemadsorption in Major Burns
Major deep burns (>20% body surface, involving deep skin layers) and associated severe inflammatory reaction and their complication are one of the biggest challenge of intensive care.
- Conditions
- Burns, Multiple Organ Failure, Shock, Organ Dysfunction Syndrome, Multiple
- Trial name
- NCT04195126
- Testing
- CytoSorb haemadsorption device
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- University of Pecs
Polyneuropathies, Septic Shock
Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock
The aim of this study is to compare the effect of EMS and conventional physical therapy on strength and muscle mass and development in adult patients with severe sepsis and septic shock.
- Conditions
- Polyneuropathies, Septic Shock, Muscle Weakness
- Trial name
- NCT03765489
- Testing
- electrical muscle stimulation, conventional physical therapy
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Chile
Critical Illness, Sepsis, Severe
Effects of IL-1β and Its Receptor Antagonists in the Treatment of Severe Infection and Inflammatory Storm in Children
In severe infective patients who survive the initial inflammatory storm, the immune response often evolves toward a state of immunosuppression, which contributes to increased mortality and severe secondary hospital-acquired…
- Trial name
- NCT04821414
- Sponsor
- Children's Hospital of Fudan University
Severe Sepsis, Septic Shock
International Multicentre Prevalence Study on Sepsis
To mark 10 years of the Surviving Sepsis Campaign (SSC), and timed to coincide with World Sepsis Day, on September 13, 2013, the SSC, ESICM and SCCM will be conducting an international point prevalence study of severe sepsis and…
- Trial name
- IMPRESS (NCT01943747)
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- European Society of Intensive Care Medicine
Severe Sepsis, Septic Shock
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic shock.
- Trial name
- NCT00934011
- Testing
- C-reactive protein guided antibiotic therapy, Procalcitonin guided antibiotic therapy
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Federal University of Minas Gerais
Sepsis, Septic Shock
Predictive algoRithm for EValuation and Intervention in SEpsis
In this prospective study, the ability of a machine learning algorithm to predict sepsis and influence clinical outcomes, will be investigated at Cabell Huntington Hospital (CHH).
- Conditions
- Sepsis, Septic Shock, Severe Sepsis
- Trial name
- PREVISE (NCT03235193)
- Testing
- Severe Sepsis Prediction, Severe Sepsis Detection
- Where
- United States
- Volunteers
- 2,296 people
- Sponsor
- Dascena
Shock, Septic, Severe Sepsis
Protocol-driven Hemodynamic Support for Patients With Septic Shock
This research is being done to see if a protocol (a set of orders that determine how much and how quickly a drug/fluid is given) for fluid and drugs used to increase blood pressure (vasopressors) will work better then general…
- Conditions
- Shock, Septic, Severe Sepsis, Sepsis
- Trial name
- NCT00335907
- Testing
- Fluid and Vasopressor Protocol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Sepsis, AKI - Acute Kidney Injury
Mechanisms of Acute Kidney Injury in Severe Infections
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography.
- Conditions
- Sepsis, AKI - Acute Kidney Injury, Positron Emission Tomography (PET)
- Trial name
- PET-AKI (NCT06372444)
- Testing
- Positron emission tomography (PET)
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uppsala University Hospital
Sepsis
Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis
Aims of the study were to find vascular markers of inflammation and endothelial damage during the course of severe sepsis in septic patients and the effects of treatment with anti-inflammatory medication (such as Drotregocin alfa…
- Trial name
- NCT00222222
- Testing
- vein puncture
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Severe Sepsis, Septic Shock
Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury
Severe sepsis or septic shock with acute kidney injury shows high mortality in intensive care unit. A few studies have shown CRRT relating the clinical improvement seems to be related to the early initiation of therapy.
- Conditions
- Severe Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT00837057
- Testing
- crrt
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Severe Sepsis
Safety and Efficacy of Talactoferrin Alfa in Patients With Severe Sepsis
Study will evaluate the safety and potential benefit of talactoferrin (recombinant human lactoferrin) as an addition to the standard care for severe sepsis.
- Trial name
- OASIS (NCT01273779)
- Testing
- Talactoferrin alfa
- Where
- 100 sites in United States, Belgium and 8 more
- Volunteers
- 1,280 people
- Sponsor
- Agennix
Severe Sepsis
Angiotensin II Antagonist in Severe Sepsis
The investigators propose a clinical study of irbersartan for the early treatment of severe sepsis patients with elevated predicted risk of death between.
- Trial name
- SartSep (NCT01992796)
- Testing
- Irbesartan
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Salerno
Covid19
Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.
Given its anti-viral, anti-oxidative, immune-enhancing, cytokine-modulating, and anticoagulant properties, the investigators hypothesize that Selenium infusion at supranutritional doses for moderately-ill, severely-ill, and…
- Trial name
- SeCOVID (NCT04869579)
- Testing
- Selenium (as Selenious Acid)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- CHRISTUS Health