Clinical trials: Severe Septic Syndrome
Severe Sepsis, Acute Respiratory Failure
Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory Failure
Rationale : Electric muscle stimulation reduced critical-illness related weakness in patients with severe sepsis and septic shock. But optimal protocol of the stimulation in unknown.
- Conditions
- Severe Sepsis, Acute Respiratory Failure, Muscle Hypotonia, Inflammation
- Trial name
- NCT01895647
- Testing
- EMS
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Mackay Memorial Hospital
Sepsis, Shock, Septic
Early Identification of Sepsis in Children
This observational nation-wide study is focused on evaluation of the new possible biomarkers for pediatric sepsis and their specificity/sensitivity in combination with usual diagnostic markers for sepsis in the terms of early…
- Conditions
- Sepsis, Shock, Septic, Sepsis, Severe, SIRS
- Trial name
- NCT03884595
- Testing
- IG, IPF, NRBC, CRP, PCT, presepsin
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Septic Shock, Vasopressor Resistance
Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock
Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40% at 28 days.
- Trial name
- ADRESS (NCT07569536)
- Testing
- Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care
- Where
- 18 sites in France
- Volunteers
- 360 people
- Sponsor
- Hospices Civils de Lyon
Severe Septic Syndrome, Septic Shock
Community Acquired Sepsis Cohort
The aim of this project is to constitute a prospective cohort of all the patients presenting to the adult emergencies of the University Hospital Centre (CHU) of Rennes for a septic syndrome of community origin.
- Trial name
- CASC (NCT03280992)
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Rennes University Hospital
Sepsis, Severe Sepsis
Implementation and Evaluations of Sepsis Watch
The purpose of this study is to study the implementation and impact of an early warning system to detect and treat sepsis in the emergency room.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03655626
- Testing
- Sepsis Watch
- Where
- United States
- Volunteers
- 32,003 people
- Sponsor
- Duke University
Sepsis
Preclinical Detection of Sepsis Early in Hospitalized Patients Following Surgery, Injury or Severe Illness
This clinical study is to evaluate a novel biomarker - CNA Rapid Sepsis Dx - to predict the development of sepsis in patients admitted to the hospital with non-sepsis conditions.
- Trial name
- Pre-SEPSIS (NCT04189549)
- Testing
- CNA Rapid Sepsis Dx
- Where
- 5 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Robert Ehrman
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis
Persistence of a marked compensatory anti-inflammatory innate immune response after an insult is termed immunoparalysis. There is no biomarker available to determine the immune status of patient.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- SIRCSS (NCT02887274)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Severe Sepsis
Glutamine Supplementation in Critically Ill Patients With Severe Sepsis
Severe sepsis is a common condition with high mortality and morbidity. A previous meta-analysis has demonstrated the safety of glutamine supplementation with suggestion of mortality and morbidity benefits in critically ill…
- Trial name
- CGH-GLU (NCT03048994)
- Testing
- Glutamine
- Where
- Singapore
- Volunteers
- 39 people
- Sponsor
- Changi General Hospital
Severe Sepsis
Safety and Efficacy Study of Recombinant Human Lactoferrin to Treat Severe Sepsis
Study will evaluate the safety and potential benefit of recombinant human talactoferrin as an addition to the standard care of severe sepsis.
- Trial name
- NCT00630656
- Testing
- Talactoferrin alfa
- Where
- 34 sites in United States, Canada and 3 more
- Volunteers
- 190 people
- Sponsor
- Agennix
Infection Due to Resistant Bacteria, Pneumonia, Ventilator-Associated
Colistin and Rifampicin for MDR-Acinetobacter
Acinetobacter baumannii causes severe infections (pneumonia, bacteremia, organ space) with high lethality in hospitalised critically ill patients.
- Conditions
- Infection Due to Resistant Bacteria, Pneumonia, Ventilator-Associated, Hospital Acquired Pneumonia, Infection of Bloodstream
- Trial name
- CoRAb (NCT01577862)
- Testing
- Colistin, Rifampicin
- Volunteers
- 210 people
- Sponsor
- University of Campania Luigi Vanvitelli
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Severe Sepsis
Comparison of Total, Salivary and Calculated Free Cortisol Levels in Patients With Severe Sepsis
Background: The purpose of the present study was to compare serum total cortisol (STC), salivary cortisol (SaC) and calculated free cortisol (cFC) levels at the baseline and after the ACTH stimulation test, in patients with…
- Trial name
- NCT02589431
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Septic Shock
Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis
The incidence of sepsis (severe infection) has increased over the last four decades. Severe sepsis and septic shock are among the leading causes of death for patients admitted to critical care units with mortality ranging from…
- Trial name
- NCT04057872
- Testing
- Therapeutic plasma exchange
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Alberta Health Services, Calgary
Sepsis, Severe, Septic Shock
High-dose Intravenous Vitamin C in Patients With Septic Shock
Despite promising observational and phase 1 data, the therapeutic potential of vitamin C for the management of septic shock has not borne out in recent large multi-centre randomized controlled trials.
- Trial name
- HIGH-VIS (NCT04796636)
- Testing
- Sodium Ascorbate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Multiple Organ Failure, Septic Shock
Early Metabolic Resuscitation for Septic Shock
This phase II trial studies how well early metabolic resuscitation therapy works in reducing multi-organ dysfunction in patients with septic shock.
- Conditions
- Multiple Organ Failure, Septic Shock, Severe Sepsis
- Trial name
- NCT03895853
- Testing
- Best Practice, early metabolic resuscitation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Trauma, Sepsis
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
Patients admitted to the Intensive Care Unit after severe injury are prone to suffer from infectious complications and even sepsis.
- Conditions
- Multiple Trauma, Sepsis, Innate Immune Response, Disorder of Neutrophils
- Trial name
- POSEIDON (NCT03489577)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Sepsis, Severe, Sepsis
Multiple Biomarkers in ICU Sepsis Patients
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality.
- Conditions
- Sepsis, Severe, Sepsis, Septic Shock, AKI
- Trial name
- NCT03802136
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhongnan Hospital
Severe Sepsis, Septic Shock
Efficacy of Mw Vaccine in Treatment of Severe Sepsis
Study Hypothesis Enhancement of Th-1 response with the help of a poly TLR agonist (Mw) is likely to increase survival in patients with severe sepsis.
- Conditions
- Severe Sepsis, Septic Shock, Immune Modulation
- Trial name
- MISS (NCT02025660)
- Testing
- Mw, 0.3ml x three days sc
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cirrhosis, Sepsis
Cohort Study of Chronic Liver Disease Complicated by Sepsis
Study population: Patients with liver cirrhosis complicated by sepsis Observation indicators: Fluid resuscitation strategy, early dynamic indicators such as MAP Observation endpoint: 28-day all-cause mortality Study design…
- Trial name
- NCT07465003
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Covid-19, Cytokine Storm
Treatment of Severe COVID-19 Patients Using Secretome of Hypoxia-Mesenchymal Stem Cells in Indonesia
In this randomized controlled trial (RCT), severe cases of COVID-19 infection will be treated with secretome of hypoxia-mesenchymal stem cells.
- Trial name
- NCT04753476
- Testing
- Injection of Secretome-MSCs, Standard treatment of Covid-19
- Where
- 6 sites in Indonesia
- Volunteers
- 48 people
- Sponsor
- Stem Cell and Cancer Research Indonesia