Clinical trials: Severe Trauma Patients
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory…
- Trial name
- NCT05697666
- Testing
- Modulation of the depth of the neuromuscular blockade
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Abnormalities, Radiation-Induced
Predictive Blood Tests for Severe Radiation Reactions in Breast Cancer Patients
Some patients who undergo breast cancer treatment with lumpectomy followed by radiation therapy develop significant late skin and soft tissue changes, resulting in a poor cosmetic outcome.
- Trial name
- NCT00652678
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- State University of New York - Upstate Medical University
Leptospirosis
N-Acetylcysteine in Patients With Leptospirosis
The goal of this clinical trial is to learn whether oral N-acetylcysteine (NAC) can reduce markers of kidney tubular injury, oxidative stress, and inflammation in adults with non-severe leptospirosis.
- Trial name
- NCT07821853
- Testing
- N-acetylcysteine
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Brain Injuries, Traumatic
The Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death and long term disability, particularly in young adults. Studies from Australia have shown that approximately half of those with severe traumatic brain injury will be…
- Trial name
- POLAR-RCT (NCT00987688)
- Testing
- Hypothermia
- Where
- 15 sites in Australia, France and 4 more
- Volunteers
- 511 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acquired Bleeding Disorder, Trauma
Evaluation of Recombinant Factor VIIa in Patients With Severe Bleeding Due to Trauma
This trial is conducted in the United States of America (USA). The purpose of this study is to evaluate the treatment of Recombinant Faction VIIa in Patients with Severe Bleeding Due to Trauma Please note that this trial and…
- Trial name
- NCT00323570
- Testing
- activated recombinant human factor VII
- Where
- 42 sites in United States
- Sponsor
- Novo Nordisk A/S
Sepsis, Lung Injury
Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery.
- Trial name
- NCT07601256
- Testing
- Inhalation Anesthesia, intravenous anesthesia
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Wounds and Injuries
Assessment of the Benefit of an Inclusive Health Organization on the Prognosis of Severe Trauma Patients
Appropriate management reduces the mortality of severe trauma victims. This is based on a pre-hospital medical assessment of severity, the initiation of life-saving treatments at the pre-hospital level, and referral to a hospital…
- Trial name
- TRAUMINXCLUSIF (NCT04275791)
- Testing
- Triage
- Where
- France
- Volunteers
- 2,193 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstetric Anal Sphincter Injury, Severe Perineal Trauma
CArE for OAsI Study: Care Pathways and Anorectal Evaluation for OASI Associated Incontinence
The aim of this study is to ascertain which pathways currently exist in relation to the follow up of patients with obstetric anal sphincter injury related incontinence.
- Conditions
- Obstetric Anal Sphincter Injury, Severe Perineal Trauma, Grade 3 Perineal Tear, Grade 4 Perineal Tear
- Trial name
- CArE for OAsI (NCT06143072)
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Anxiety Disorders, Stress Disorders, Post-Traumatic
MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients
Pregnant and postpartum patients hospitalized for medical complications experience high rates of depression, anxiety, and trauma-related symptoms, yet access to timely psychiatric care during obstetric hospitalization is limited.
- Conditions
- Anxiety Disorders, Stress Disorders, Post-Traumatic, Pregnancy, High Risk, Depressive Disorder, Major
- Trial name
- MOCHA (NCT07540585)
- Testing
- Collaborative Mental Health Care Program (CMHCP)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Indiana University
Respiratory Failure, Traumatic Brain Injury
A Prospective, Randomized Trial of Early Versus Late Tracheostomy in Trauma Patients With Severe Brain Injury
The purpose of this study is to evaluate the efficacy of early conversion tracheostomy from endotracheal intubation (ET) to percutaneous, dilatational tracheostomy (PDT) in traumatic brain-injured patients requiring prolonged…
- Trial name
- NCT00292097
- Testing
- Early tracheostomy, Late tracheostomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Memorial Medical Center
Peripheral Arterial Disease, Myocardial Injury
Cardiovascular Risk in Peripheral Artery Disease Patients Undergoing Endovascular Revascularisation
This study will investigate heart-related complications in patients with peripheral arterial disease (PAD) undergoing endovascular revascularization procedures to improve blood flow in the legs.
- Conditions
- Peripheral Arterial Disease, Myocardial Injury, Troponin, NT-proBNP
- Trial name
- RISK (NCT07599540)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Kidney Diseases, Acute Kidney Injury
Development of a Decision-making Aid for Referring Severe Kidney Injury Patients for Nephrology Consultations
Acute kidney injury is a frequent and growing complication associated with a risk of progressing into a chronic kidney disease. Recent guidelines have recommended systematic consultations with a nephrologist 3-6 months following…
- Trial name
- IRA Cible (NCT03192189)
- Testing
- monitoring for progression to chronic kidney disease
- Where
- France
- Volunteers
- 319 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury
Acute Kidney Attack in Severe Traumatized Patients
Acute Kidney Injury (AKI) is a common complication of severe traumatized patients. The diagnosis is often delayed. The Nephrocheck® test allows an earlier assessment of renal stress.
- Trial name
- NEPHROTRAUMA (NCT03877978)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury
Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients
Intensive care management of patient with severe traumatic brain injury (TBI) includes deep and prolonged sedation with intravenous hypnotics (propofol, midazolam, ketamine) in combination with opioids to prevent and/or treat…
- Trial name
- IsoSAFE (NCT06311604)
- Testing
- Isoflurane
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Snake Bite, Weaning
Automatic Tube Compensation (ATC) for Weaning Patients With Severe Neurotoxic Snake Envenoming
In the mechanically ventilated patient, the single greatest cause of imposed work of breathing is the resistance caused by the endotracheal tube.
- Conditions
- Snake Bite, Weaning, Mechanical Ventilation
- Trial name
- ATC (NCT00804011)
- Testing
- ATC, PSV
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Diabetes Mellitus, Type 2
Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Empagliflozin (Jardiance), a highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), was approved in Europe in May 2014 for the treatment of type 2 diabetes mellitus (T2DM) to improve glycaemic…
- Trial name
- NCT02864914
- Testing
- Empagliflozin, DPP-4 inhibitors
- Where
- United Kingdom
- Volunteers
- 333,580 people
- Sponsor
- Boehringer Ingelheim
Abdominal Injury, Thoracic Injury
Outcome of Patients With Thoraco-abdominal Injury and Stress-induced Hyperglycemia or Diabetic Hyperglycemia
This study aimed to measure the effects of SIH and DH on the mortality outcomes of the adult patients with moderate to severe thoracoabdominal injury
- Conditions
- Abdominal Injury, Thoracic Injury, Hyperglycemia, Hyperglycemia Stress
- Trial name
- NCT04058015
- Testing
- Stress-induced hyperglycemia, Diabetic hyperglycemia, Diabetic normoglycemia
- Where
- Taiwan
- Volunteers
- 802 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoporosis Fracture
Continuation of Anti-osteoporotic Treatment 1 Year After Initial Administration
The aim of this observational study is to assess the obstacles and levers to the continuation of anti-osteoporotic treatment, and to identify those where action could be taken to improve the quality of care for fractured…
- Trial name
- POUROSTEO (NCT06024148)
- Testing
- phone survey
- Volunteers
- 250 people
- Sponsor
- University Hospital, Grenoble
Drug Clearance After Severe Burn Injury
Pharmacokinetic Analysis of Cefiderocol in Patients With Acute Burn Injuries
Cefiderocol is a powerful, broad spectrum antibiotic approved to treat hospital-acquired or ventilator associated pneumonia and urinary tract infections.
- Trial name
- NCT07465432
- Testing
- Cefiderocol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Tennessee