Clinical trials: Severe Trauma Patients
Ankle Injuries, Fracture, Ankle
Patient Education Using 3D Printed Model
Complex high energy fractures of the lower extremity are life changing injuries and are known to be associated with poor functional outcome post operatively.
- Trial name
- NCT04009252
- Testing
- 3D Model Education
- Volunteers
- 28 people
- Sponsor
- Ottawa Hospital Research Institute
Traumatic Brain Injury
Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury
Effect of Early Memantine Administration on Outcome of Participents with Moderate to Severe Traumatic Brain Injury
- Trial name
- NCT05531383
- Testing
- Memantine Hydrochloride
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
TBI (Traumatic Brain Injury), Acute Brain Injuries
Study of Cerebral Tissue Oxygenation During Transfusion in Traumatic Brain Injury
This proposal aims to provide some objective, non-invasively achieved, physiologically relevant data in order to provide some rational basis for decision-making for transfusion in sTBI.
- Trial name
- NIRSTBI (NCT01728831)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Burns
Cardiovascular Biomarkers and Lung Edema in Severe Burns Patients
Burn injury leads to hypovolemic then distributive shock. Fluid resuscitation remains the cornerstone of initial treatment of burn shock.
- Trial name
- CAROLE (NCT03271268)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Acute Brain Injuries, Moderate to Severe Traumatic Brain Injury
Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)
This study is a multicenter, randomized controlled trial aimed at evaluating the effectiveness and safety of recombinant human growth hormone (rhGH) in elderly patients who have suffered moderate to severe acute brain injuries…
- Trial name
- GH-ABI-RCT (NCT07481656)
- Testing
- Recombinant Human Growth Hormone (rhGH) Injection, Standard Care (Treatment as Usual)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Anhui Provincial Hospital
Acute Kidney Injury
Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery.
- Trial name
- POAKIDS (NCT07351149)
- Where
- 16 sites in Australia, Brazil and 8 more
- Volunteers
- 2,000 people
- Sponsor
- Uppsala University
Resuscitation, Trauma Patients
Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM)
This study involved the medical record review of resuscitation records for all severely-injured trauma patients requiring emergent surgical intervention and significant acidosis from 2005 through 2009.
- Trial name
- THAM (NCT01326260)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Burns
Investigation of the Effect of Exercise Protocol Determined According to Metabolic Rate in Early Burn Patients on Coagulation, Fibrinolytic Activity and Functional Capacity
The aim of this study is; To investigate the Effect of the Exercise Protocol Determined According to Metabolic Rate in Early Burn Patients on Coagulation, Fibrinolytic Activity and Functional Capacity, and to create an exercise…
- Trial name
- NCT04663113
- Testing
- Control Group/1st group ( standard physiotherapy, 2nd group- Standard physiotherapy + bicycle ergometer, 3rd group- Standard physiotherapy + exercise protocol to be developed
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Hasan Kalyoncu University
Laryngeal Edema, Acute Respiratory Failure Requiring Reintubation
Evaluation of Laryngeal Ultrasonography Performance in Predicting Major Post Extubation Laryngeal Edema in Intensive Care Patients
For patient in intensive care unit, extubation failure is defined as the necessity of early reintubation after scheduled extubation, with Increased morbidity and mortality, so it seems important to quickly identify patients with…
- Trial name
- ECHOLPE (NCT01857674)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Corneal Epithelial Disorders
Safety and Efficacy of SJP-0035 Ophthalmic Solution in Patients With Moderate to Severe Corneal Epithelial Disorders
The purpose of this study is to determine whether SJP-0035 ophthalmic solution is effective in promoting corneal epithelial wound healing in conditions associated with corneal epithelial disorders.
- Trial name
- NCT02929823
- Testing
- High Dose SJP-0035 Ophthalmic Solution, Low Dose SJP-0035 Ophthalmic Solution, Vehicle of SJP-0035 Ophthalmic solution
- Where
- 19 sites in United States
- Volunteers
- 130 people
- Sponsor
- Senju Pharmaceutical Co., Ltd.
Trauma
Trial Of Normal Saline Versus Ringer's Lactate In Paediatric Trauma Patients
Background: Trauma is a major cause of death in children and teenagers. When young patients have suffered major traumatic injuries, they require intravenous (iv) fluids to keep their blood vessels full and ensure blood flow to…
- Trial name
- NCT01692769
- Testing
- Normal Saline, Ringer's Lactate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Severe Trauma
Evaluation of the Vittel Criteria for Pre-hospital Triage of Severe Trauma Patients in the French West Indies and in French Guiana
Severe trauma is a public health problem because it is the leading cause of death in young people and the third leading cause of death in France for all ages.
- Trial name
- TRAUMA-DOM (NCT06580262)
- Testing
- Routine care
- Where
- 2 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital Center of Martinique
Hypothermia, Trauma
Zero Heat Flux Temp Monitor on Discharge Hypothermia Among Trauma Patients (RUZIT Trial)
Hypothermia amongst trauma patients is a persistent problem that increases the relative risk of transfusion as well as morbidity and mortality.
- Conditions
- Hypothermia, Trauma, Temperature Change, Body
- Trial name
- RUZIT (NCT03313258)
- Testing
- Standard of Care Group, Active Warming Group
- Where
- Canada
- Sponsor
- Dr. Asim Alam
Electrolyte Disturbances, Subarachnoid Hemorrhage
Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain Injury
During the course of their acute illness patients with subarachnoid hemorrhage and severe traumatic brain injury often develop disturbances in their fluid balance and electrolyte homeostasis.
- Conditions
- Electrolyte Disturbances, Subarachnoid Hemorrhage, Traumatic Brain Injury, Natriuretic Peptides
- Trial name
- NCT01313975
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Traumatic Brain Injury
TBI-Prognosis Multicenter Prospective Study
Severe traumatic brain injury (TBI) is the leading cause of death and disability among people under 45 years of age and a major public health problem.
- Trial name
- NCT02452541
- Testing
- Prognostic tests
- Where
- 17 sites in Canada
- Volunteers
- 315 people
- Sponsor
- CHU de Quebec-Universite Laval
Burns
Effect of Music Therapy on Families of Burn Patients
The purpose of this study is to investigate the efficacy of music therapy in assisting with the coping and adjustment of children of adults with major burns.
- Trial name
- MTS3 (NCT00824681)
- Testing
- Sound Of Family Together (S.O.F.T.) Music Program, Non-Therapy Related Activities (NTRA)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- MetroHealth Medical Center
Burns, Physiotherapy
The Effect of Early Physiotherapy on Biochemical Parameters in Major Burn Patients: A Burn Center's Experience
Background: This study planned to investigate the effect of early physiotherapy on biochemical parameters in major burn patients. Methods: Ten women (50%) and 10 men (50%) aged 21-47 years old were included in our study.
- Conditions
- Burns, Physiotherapy, Exercises
- Trial name
- NCT03520816
- Testing
- Burn Physiotherapy Protocol
- Volunteers
- 20 people
- Sponsor
- Hasan Kalyoncu University
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
COVID-19
Adrecizumab (HAM8101) to Improve Prognosis and Outcomes in COVID-19 Trial
The clinical trial is designed as a prospective, multi-center, double-blind, randomised, placebo-controlled, interventional trial to assess safety, tolerability and efficacy of Adrecizumab (on top of SOC) in patients with…
- Trial name
- AGNES-19 (NCT05156671)
- Testing
- Adrecizumab (HAM 8101)
- Where
- 13 sites in Germany
- Volunteers
- 16 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Severe Brain Injury
Study of PbiO2 Variation by Body Temperature and Capnia in Severe Head Trauma Patients Treated With Targeted Temperature Control
Serious head trauma is a common and pathology and responsible of high morbidity and mortality. The major challenge, from the very first hours, is to limit cerebral ischemia by controlling secondary brain injury factors.
- Trial name
- TODAY (NCT04109430)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest