Clinical trials: Severe Trauma Patients
Major Trauma
The Effects of Acupuncture for Major Trauma
Major trauma is a significant cause for morbidity and mortality in the world. After traumatic injury, the damage tissue could induce systemic inflammatory response (SIRS) and activate autonomic nervous system in response to…
- Trial name
- NCT04970433
- Testing
- Electroacupuncture (EA), Laser acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Severe Sepsis, Acute Lung Injury
Citrulline in Severe Sepsis
This is a randomized, double-blind, placebo-controlled, phase 2 study to evaluate biochemical, clinical, and safety effects of 2 doses of intravenous L-citrulline compared to placebo in patients with severe sepsis at risk for or…
- Trial name
- NCT01474863
- Testing
- High Dose Citrulline, Low Dose Citrulline
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt University
ARDS, Driving Pressure
Effects of Different Driving Pressure on Lung Stress, Strain and Mechanical Power in Patients With Moderate to Severe ARDS
ARDS is the most common acute respiratory failure in the ICU and the mortality rate is still as high as 40%. Mechanical ventilation(MV) is the major supportive treatment for ARDS, but inappropriate ventilator setting could lead…
- Conditions
- ARDS, Driving Pressure, Strains, Mechanical Power
- Trial name
- NCT03616704
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jianfeng Xie
Respiration, Artificial
Practice of Mechanical Ventilation in Patients With Severe Brain Injury in China
The mechanical ventilation strategy has changed over years worldwide. Several international researches have been conducted to study the association of the use of mechanical ventilation with clinical outcomes.
- Trial name
- NCT02517073
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Capital Medical University
Traumatic Brain Injury, Severe Traumatic Brain Injury
Vagus Nerve Stimulation in Patients in Comatose State
Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation.
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
- Trial name
- NCT07719595
- Testing
- Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sima Mofakham
Non-compressible Torso Hemorrhage, Trauma Injury
Resuscitative Endovascular Balloon Occlusion of the Aorta in Haemorrhagic Shock
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a procedure that has the goal to stabilize trauma patients with non-compressible torso hemorrhage by temporarily occluding the aorta with a ballon catheter to…
- Trial name
- NCT05941572
- Where
- Austria
- Sponsor
- Medical University of Graz
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Neurodegenerative Diseases, Stroke
The Role of Humanoid Robot in Neuropsychological Assessment and Cognitive Training.
The role of humanoid robot in neuropsychological assessment and conducting cognitive training in patients with dementia and severe brain injury" Objectives Use of robotic solutions to carry out diagnostic and rehabilitation…
- Trial name
- NCT05788133
- Testing
- treatment and screening by neuropsychological tests on humanoid robot
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Anesthesia, Burned
Development of pk/pd Model of Propofol in Patients With Severe Burns
Burn injuries are a prevalent problem. Actually, in Chile the Ministry of Health has recorded 6435 hospital burns and has reported 569 deaths from this cause.
- Conditions
- Anesthesia, Burned, Operative Wound
- Trial name
- HUAPQ (NCT03704285)
- Testing
- Propofol, BIS
- Where
- Chile
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Victor Contreras, MSN
Emphysema
Bronchoscopic Thermal Saline Ablation (BTSA) of Emphysematous Lung. A New Emphysema Therapy
Aim: To evaluate feasibility, safety and efficacy of relatively simple approach of bronchoscopic lung volume reduction (LVR) technology, independent of collateral ventilation.
- Trial name
- BTSA (NCT01920321)
- Testing
- Endoscopic lung volume reduction
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Assaf-Harofeh Medical Center
Consciousness Disorders, Brain Injuries
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired…
- Conditions
- Consciousness Disorders, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- NCT03367078
- Testing
- Anodal tDCS, Usual care
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Acute Kidney Injury, Severe Sepsis
Acute Kidney Injury in Septic Critically Ill Patients : Are Aminoglycosides Really Harmful?
The purpose of the present study is to determine whether administration of aminoglycosides in septic critically ill patient is a risk factor for acute kidney injury
- Trial name
- REAMICHOC (NCT01932814)
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Disorders of Consciousness Due to Severe Brain Injury
Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of Consciousness
Effective treatment options for disorders of consciousness (DoC) remain limited, and available interventions show heterogeneous efficacy.
- Trial name
- Wells-DoC II (NCT07535593)
- Testing
- Transcutaneous electrical stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xijing Hospital
Perioperative/Postoperative Complications, Risk Factor, Cardiovascular
Myocardial Injury in Noncardiac Surgery in Sweden
The purpose of this multicentre, prospective, observational study is to identify robust biochemical markers that predict adverse cardiovascular outcomes and mortality in patients undergoing major abdominal surgery.
- Trial name
- MINSS (NCT03436238)
- Where
- 7 sites in Sweden
- Volunteers
- 1,269 people
- Sponsor
- Linkoeping University
Acute Kidney Injury
Effects of BRS and LRS on Postoperative Acute Kidney Injury
1. Title: Effects of Sodium Bicarbonate Ringer's Injection and Sodium Lactated Ringer's Injection on postoperative acute kidney injury in patients undergoing major abdominal surgery: a randomized, controlled, open-label clinical…
- Trial name
- BRS/LRS (NCT04835038)
- Testing
- Sodium Bicarbonate Ringer's Injection, Sodium Lactated Ringer's Injection
- Where
- China
- Volunteers
- 3,400 people
- Sponsor
- Tongji Hospital
Systemic Oxygenation vs ROS Formation in TBI Patients
ROS in TBI Patients in Relation to Level of Oxygenation.
This project an observational study performed on patients with severe Traumatic Brain Injury (TBI) treated at Neurosurgical ICU (NICU) at Karolinska University Hospital.
- Trial name
- ROS-TBI (NCT05101278)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Stockholm
Traumatic Injury, Muscle Injury
Musculotendinous Tissue Unit Repair and Reinforcement (MTURR) Coordinating Center
The objective of the study is to assess mechanical strength and function in subjects undergoing Musculotendinous Tissue Unit Repair and Reinforcement (MTURR) with the use of biologic scaffolds for the restoration of both…
- Conditions
- Traumatic Injury, Muscle Injury, Tendon Injury, Soft Tissue Injury
- Trial name
- MTURR (NCT01497678)
- Testing
- Extracellular Matrix
- Where
- United States
- Sponsor
- University of Pittsburgh
Major Trauma
Experiences of Visitors to a Regional Major Trauma Intensive Care Unit
Since 2011, people who have had a serious accident in England are no longer looked after at the hospital nearest to them. Instead, they are cared for at a specialist hospital called the regional major trauma centre.
- Trial name
- VISIT_ICU (NCT03259776)
- Testing
- Qualitative interviews and questionnaire survey
- Where
- United Kingdom
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Kingston University
Brain Injuries
Modeling Outcome in Patients With Acquired Brain Injuries
Acquired brain injury (ABI) is the leading cause of death and disability worldwide. The degree of severity varies according to a combination of numerous demographics, etiological, clinical, cognitive, behavioral, psychosocial and…
- Trial name
- MOF-ABI (NCT06162091)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Brain Injury, Constipation
Gastrointestinal Transit Time in Patients With Severe Acquired Brain Injury
Empirically patients with acquired brain injury (ABI) are often constipated. This is a major clinical issue. Nevertheless, this has only been sparsely studied.
- Trial name
- NCT02428790
- Volunteers
- 25 people
- Sponsor
- University of Aarhus