Clinical trials: Severe Trauma Patients
Traumatic Brain Injury
Early Diagnosis of Mortality Using Admission CT Perfusion in Severe Traumatic Brain Injury Patients (ACT-TBI Study)
Background: Severe traumatic brain injury (TBI) is a principal cause of post-injury hospitalization, disability, and death throughout the world.
- Trial name
- ACT-TBI (NCT04318665)
- Testing
- CT Perfusion
- Where
- 4 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Traumatic Brain Injury
The Effect of Different Emergency Medical Systems on the Prognosis of Traumatic Brain Injury - a Prospective Study
The Aim of the Study is to Measure the Effect of Finnish Physician-staffed EMS Unit Treatment Methods on Traumatic Brain Injury (TBI) Patient Prognosis. Physician-staffed HEMS unit was implemented to the EMS 2011.
- Trial name
- NCT01571375
- Where
- Finland
- Volunteers
- 400 people
- Sponsor
- Tampere University Hospital
Trauma, Critical Illness
Enteral Glutamine Supplementation for the Patient With Major Torso Trauma
Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function.
- Conditions
- Trauma, Critical Illness, Shock
- Trial name
- NCT00178581
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Opiate
A Dosing and Efficacy Study of Intra-nasal Sufentanil for Moderate to Severe Pain
The purpose of this study is to determine the appropriate dose and effectiveness of intra-nasal administration of a potent narcotic, sufentanil, for the treatment of moderate to severe pain due to broken bone(s) in the arm or leg.
- Trial name
- NCT01012999
- Testing
- sufentanil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Head Trauma, Craniocerebral Injuries
Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the a portable near-infrared-based device (portable NIR-based device), the InfraScanner 2000™, to detect…
- Conditions
- Head Trauma, Craniocerebral Injuries, Crushing Skull Injury, Head Injuries
- Trial name
- NCT04505293
- Testing
- InfraScanner 2000™
- Where
- 2 sites in United States, Uganda
- Volunteers
- 672 people
- Sponsor
- Duke University
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Brain Injury, Consciousness Disorders
Early Stepping Verticalization in ICU for ABI Patients
Verticalization was reported to improve the level of arousal and awareness in patients with severe acquired brain injury (ABI) and to be safe in ICU.
- Trial name
- NCT02828371
- Testing
- stepping verticalization, conventional mobilization
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Subacromial Impingement Syndrome
Comparison of Two Stretching Techniques in Patients Suffering From Subacromial Syndrome
The shoulder stability has always been related to the rotator cuff complex, although more and more is contemplated the Teres Major muscle and its affectation in the shape of the trigger points within this pathology.
- Trial name
- NCT04073199
- Testing
- Long Lever Group, Short Lever Group
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Major Depressive Disorder, Childhood Trauma
RESET-psychotherapy: the Effectiveness of Trauma-focused Therapy in Patients With Depression and Childhood Trauma
Depression is a debilitating psychiatric disorder with a recurrent and progressive course. Around 25% of depressive patients has experienced moderate to severe levels of childhood trauma (CT), resulting in earlier onset and more…
- Trial name
- NCT05149352
- Testing
- Treatment as usual (TAU) for depression, Trauma-focused therapy (TFT)
- Where
- 3 sites in Netherlands
- Volunteers
- 158 people
- Sponsor
- Amsterdam UMC, location VUmc
COVID-19
Zilucoplan® in Improving Oxygenation, Short-, Longterm Outcome of COVID19 Patients With Acute Hypoxic Respiratory Failure
The study is a randomized controlled, open-label trial comparing subcutaneous Zilucoplan® with standard of care to standard of care alone.
- Trial name
- ZILU-COV (NCT04382755)
- Testing
- Zilucoplan®
- Where
- 9 sites in Belgium
- Volunteers
- 81 people
- Sponsor
- University Hospital, Ghent
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery
One technique for the nerve block involves injecting the numbing medicine where the nerve is together (higher up in the back of the thigh).
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot
- Trial name
- NCT01550094
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Chest Trauma
Bronchoscopy for Thoracic Trauma Patients
The study aims to evaluate the effectiveness of bronchoscopic sputum suction in patients with severe thoracic illness-induced respiratory failure.
- Trial name
- NCT06264856
- Testing
- bronchoscopic sputum suction, negative pressure aspiration suction
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Critical Illness, Acute Kidney Injury
Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study
This study aims to determine changes in kidney function during and after critical illness, comparing conventional creatinine based methods with the gold standard to accurately establish the presence of new or worsened chronic…
- Conditions
- Critical Illness, Acute Kidney Injury, Muscle Loss, Major Trauma
- Trial name
- KRATOS (NCT03736005)
- Testing
- Exposure of significant critical illness
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Postoperative Acute Kidney Injury
Preoperative Nutritional Status and Postoperative Acute Kidney Injury
There is a high prevalence of postoperative acute kidney injury (AKI) in patients who undergo intra-abdominal surgery, and it is particularly common in the elderly.
- Trial name
- NCT05945940
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,977 people
- Sponsor
- Rao Sun
Head Injury Trauma, Hyperventilation
Hyperventilation in Patients With Traumatic Brain Injury
Elevated intracranial pressure is a dangerous and potentially fatal complication after traumatic brain injury. Hyperventilation is a medical intervention to reduce elevated intracranial pressure by inducing cerebral…
- Trial name
- NCT03822026
- Testing
- Hyperventilation test
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Wounds and Injuries, Traumatic Shock
Prospective Validation of the SHOCKMATRIX Hemorrhage Predictive Model
Management of post-traumatic severe hemorrhage remains a challenge to any trauma care system. Studying integrated and innovative tools designed to predict the risk of early severe hemorrhage (ESH) and resource needs could offer a…
- Conditions
- Wounds and Injuries, Traumatic Shock, Hemorrhagic Shock
- Trial name
- SHOCKMATRIX (NCT06270615)
- Testing
- Ambispective validation of machine learning-based predictive model
- Where
- 8 sites in France
- Volunteers
- 1,584 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Traumatic Brain Injury, Intracranial Hypertension
Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents
Severely brain injured patients are at high risk of intracranial hypertension. Among medical treatments (sedatives), neuromuscular blocking agents (NMBA) are recommended by french but not english speaking societies.
- Trial name
- THIC Cu (NCT02404779)
- Testing
- cisatracurium besilate
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Clermont-Ferrand
Craniocerebral Trauma, Traumatic Brain Injury
Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Traumatic Brain Injury.
The aim of this study is to determine whether passive gait training increases arousal, demonstrated as changes in EEG (electroencephalogram) activity.
- Conditions
- Craniocerebral Trauma, Traumatic Brain Injury, "Rehabilitation"
- Trial name
- NCT00430703
- Testing
- body weight support treadmill training
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Traumatic Brain Injury
Study of Oxycyte in Severe Closed Head Injury
Brain damage as a result of decreased oxygen to the brain is found in 80% of patients that die with severe head injuries. Laboratory studies in animals and clinical trials have shown that increasing oxygen in the brain results in…
- Trial name
- NCT00174980
- Testing
- Oxycyte
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Tenax Therapeutics, Inc.