Clinical trials: Severe Trauma Patients
Perioperative Myocardial Injury, Autonomic Dysfunction
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Limiting perioperative tachycardia (aiming for a heart rate <90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing…
- Conditions
- Perioperative Myocardial Injury, Autonomic Dysfunction, Cardiovascular (CV) Risk, Major Surgery
- Trial name
- LANTA-P (NCT07168421)
- Testing
- Landiolol
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Trauma
Multicentre Study: Adherence to the Severe Trauma Patients Pathway in PACA Region
Trauma patient management concerns more than 140,000 patients per year in France. PACA Regional Emergency Observatory (ORU) has issued recommendations to optimize the management of these trauma patients from pre-hospital phase to…
- Trial name
- FILTRAUMA-PACA (NCT05401487)
- Testing
- Pre-hospital and hospital care
- Where
- 3 sites in France
- Volunteers
- 265 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Acute Kidney Injury
Acute Kidney Attack in Severe Traumatized Patients
Acute Kidney Injury (AKI) is a common complication of severe traumatized patients. The diagnosis is often delayed. The Nephrocheck® test allows an earlier assessment of renal stress.
- Trial name
- NEPHROTRAUMA (NCT03877978)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Hospices Civils de Lyon
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Trigger Points in Teres Major Muscle, Subacromial Impingement Syndrome
Teres Major Muscle and Subacromial Impingement Syndrome
There is not a clear understanding of the origin of symptoms perceived by patients with impingement of the soft tissue structures of the subacromial space.
- Trial name
- NCT02374125
- Testing
- Diacutaneous Fibrolysis, Trigger Point Pressure Release, Protocolized physiotherapy
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Trauma Injury
How Many Patients Suffering Major Trauma Would be Eligible for a Pre-hospital Transfusion
The aim of the study is to measure the number of patients being cared for by a medical team for major trauma who could benefit from a transfusion labile blood products and thus provide a scientific argument in favour of supplying…
- Trial name
- TRAP (NCT06494293)
- Testing
- Data Collection
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Hôpital NOVO
Influenza, Acute Lung Injury
Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage
The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals.
- Conditions
- Influenza, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- FluBAL (NCT01089400)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Trauma, Critical Illness
Enteral Glutamine Supplementation for the Patient With Major Torso Trauma
Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function.
- Conditions
- Trauma, Critical Illness, Shock
- Trial name
- NCT00178581
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Kidney Injury
Efficacy Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Kidney Injury
The purpose of this protocol is to evaluate the safety of a selective cytopheretic device (SCD) in patients that are on continuous renal replacement therapy (CRRT) for acute kidney injury (AKI).
- Trial name
- NCT01400893
- Testing
- SCD
- Where
- 26 sites in United States
- Volunteers
- 134 people
- Sponsor
- SeaStar Medical
Traumatic Brain Injury (TBI)
Noninvasive Monitoring of Cerebral Blood Flow Autoregulation in Patients With Traumatic Brain Injury (TBI)
BACKGROUND: The brain is very sensitive to both excessive and insufficient flow of blood. Cerebral blood flow (CBF) is normally auto-regulated by the blood vessels in the brain, but this protective mechanism is often disturbed…
- Trial name
- REG01 (NCT01605838)
- Where
- United States
- Sponsor
- Advanced Brain Monitoring, Inc.
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of Consciousness
The main questions this study aims to answer are: Can low-intensity FUS neuromodulation be safely and feasibly administered to the bilateral central thalamus in patients with disorders of consciousness (DoC)? Does FUS…
- Trial name
- NCT07694258
- Testing
- Next Generation Dome Helmet (NGDH)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Moderate-to-Severe Traumatic Brain Injury
Comparing Sedatives for Intracranial Pressure Control in Traumatic Brain Injury
The goal of this clinical trial is to compare the effects of propofol, midazolam, and dexmedetomidine on intracranial pressure control and clinical outcomes in adults with moderate-to-severe traumatic brain injury undergoing…
- Trial name
- ICP-TBI (NCT07678216)
- Testing
- propofol, midazolam, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Aswan University
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage (ICH)
Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG
The purpose of this study is to show if it is possible to detect secondary ischemic events in patients with severe brain injury or cerebral haemorrhage with the help of non-invasive near-infrared spectroscopy (NIRS) by using the…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage (ICH), Traumatic Brain Injury
- Trial name
- NCT01836848
- Testing
- measuring cerebral perfusion by NIRS with ICG
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Cologne
Brain Injuries
Invasive and Non-Invasive Assessment of Cerebral Oxygenation in Patients With Severe Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain…
- Trial name
- NCT00703495
- Testing
- transcranial oxygen saturation measurement (INVOS Somanetics 5100C)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Burns
Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Burns
The Total Parenteral Nutrition (TPN)received as part of your routine burn care has optimal levels of protein and sugar, however the best mixture of amino acids for a patient with burn wounds is not yet known.
- Trial name
- NCT00216996
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Diabetes, Infection
Technology That Permits Focal Dose of Antibiotics to be Delivered to Lower Limb(s) of Diabetic Patients
The use of the Percutaneous Isolated Limb Procedure (PILP) which enables the use of existing antibiotic therapies in a more targeted and concentrated fashion in patients with diabetes who have a significant lower limb infection…
- Trial name
- NCT02158442
- Testing
- Percutaneous Isolated Limb Perfusion (PILP) delivery, Timentin
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Osprey Medical, Inc
Traumatic Brain Injury
Early Diagnosis of Mortality Using Admission CT Perfusion in Severe Traumatic Brain Injury Patients (ACT-TBI Study)
Background: Severe traumatic brain injury (TBI) is a principal cause of post-injury hospitalization, disability, and death throughout the world.
- Trial name
- ACT-TBI (NCT04318665)
- Testing
- CT Perfusion
- Where
- 4 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Posttraumatic Stress Disorder
Dialectical Cognitive Traumatherapy (DCT) on Patients With Severe PTSD Following Sexual Abuse
The purpose of this study is to determine whether Dialectical Cognitive Traumatherapy is effective in the treatment of severe and chronic Posttraumatic Stress Disorder (PTSD) following childhood sexual abuse.
- Trial name
- PASA (NCT00481000)
- Testing
- Dialectical Cognitive Therapy
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Brain Injury
Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury
The purpose of this study is to test the drug apomorphine in subjects who are in a Vegetative State or a Minimally Conscious State.
- Trial name
- NH001-2 (NCT00761228)
- Testing
- Apomorphine
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NeuroHealing Pharmaceuticals Inc.