Clinical trials: Severe Trauma Patients
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Spinal Cord Contusion
Allogeneic Cord Blood Cells for Adults With Severe Acute Contusion Spinal Cord Injury
Study evaluates the safety and primary efficiency of systemic (i.v.) allogeneic human umbilical cord blood mononuclear cell infusions in patients with severe acute contusion spinal cord injury (ASIA A/B).
- Trial name
- NCT04331405
- Testing
- Human Allogeneic Umbilical Cord Blood Mononuclear Cells (hUCBMCs) systemic (i.v.) infusions
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Postoperative Acute Kidney Injury, Postoperative Complications
Hypotension Prediction Index-guided Hemodynamic Optimization Trial to Reduce Postoperative Acute Kidney Injury (HYT).
MAIN AIM OF THE STUDY To establish whether hemodynamic management guided by the hypotension prediction index (HPI) guided by the administration of intravenous fluids and vasoactive drugs in patients undergoing elective major…
- Trial name
- HYT (NCT05569265)
- Testing
- Intraoperative hemodynamic management
- Where
- 26 sites in Spain
- Volunteers
- 958 people
- Sponsor
- Maria José Clara Colomina Soler
Severe Traumatic Brain Injury
Study of the Safety and Efficacy of Conivaptan (Vaprisol®) to Raise Serum Sodium Levels in Patients With Severe Traumatic Brain Injury
The investigators plan to utilize conivaptan (Vaprisol) to promote isolated water loss, in combination with normal (physiologic) fluid replacement to maintain a normal blood volume status, in patients with severe TBI.
- Trial name
- NCT00930202
- Testing
- Conivaptan (Vaprisol)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Traumatic Brain Injury, Traumatic Encephalopathy
Ketamine in Severe Traumatic Brain Injury
Traumatic brain injury (TBI) accounts for approximately 2.5 million visits to emergency departments in the United States each year.
- Trial name
- NCT06062628
- Testing
- Ketamine Hydrochloride
- Sponsor
- University of Texas Southwestern Medical Center
Transfusion Adverse Reaction, Major Trauma
Blood Storage Related Mortality and Adverse Effects in Trauma Patients
The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions: 1.
- Conditions
- Transfusion Adverse Reaction, Major Trauma, Blood Product Transfusion for All Conditions
- Trial name
- NCT07341139
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital
ICU, Trauma Injury
Current Situation and Analysis of ICU Management for Severe Trauma Patients in China
Over the past 10 years, there has not been a consensus on ICU nursing management based on the concept of injury control. Case management for patients with serious trauma continues to be initiated in general services and after…
- Conditions
- ICU, Trauma Injury, ICU Acquired Weakness
- Trial name
- NJJLISTP (NCT04944537)
- Testing
- No Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lulu Gu
Trauma, Chronic Pain
Pain Multidisciplinar Intervention in Major Trauma Patients
In Spain, major trauma continues to be the leading cause of death among young people. However, mortality rates represent only a relatively small part of the impact of trauma injuries on the health of the population.
- Conditions
- Trauma, Chronic Pain, Psychological Trauma
- Trial name
- NCT05355441
- Testing
- Paracetamol, Ibuprofen 600 mg, Tramadol
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Nuria Llorach-Perucho
Burns, Liver Fibroses
Liver, Pancreas and Thyroid Function in Burn Patients
The purpose of this study is to determine the extent to which severe burn injuries affect the morphology and function of liver, pancreas and thyroid.
- Conditions
- Burns, Liver Fibroses, Pancreas Disease, Thyroid Diseases
- Trial name
- NCT03598283
- Testing
- Ultrasound/transient elastography
- Where
- United States
- Sponsor
- The University of Texas Medical Branch, Galveston
Myocardial Injury After Non-cardiac Surgery, Urologic Cancer
Prediction of Myocardial Injury After Non-Cardiac Surgery in Urologic Cancer Patients
This prospective multicenter observational study aims to evaluate the predictive value of artificial intelligence-based analysis of preoperative 12-lead electrocardiography for myocardial injury after non-cardiac surgery (MINS)…
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Urologic Cancer, Major Adverse Cardiovascular Events (MACE)
- Trial name
- URO-MINS (NCT07634666)
- Testing
- No intervention assigned
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Anam Hospital
Dry Eye Syndrome
Piiloset Trehalose Emulsion Eye Drop Study in Moderate or Severe Dry Eye
The study evaluates the safety, ocular tolerability and efficacy of emulsion eye drops with sacha inchi seed oil, trehalose and hyaluronic acid in the treatment of moderate or severe dry eye in adult patients.
- Trial name
- NCT03569202
- Testing
- Piiloset Trehalose Emulsion Eye Drops, Control Eye Drops
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Kuopio University Hospital
Traumatic Brain Injury
Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patient
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- IOE-TBI (NCT06261281)
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- China
- Sponsor
- Zeng Changhao
Kidney Injury, Acute, Intensive Care Unit ICU
Acute Kidney Injury - Epidemiology in Intensive Care Unit Patients 2: an International Multicenter Cohort Study
The goal of this observational study is to learn the epidemiology and outcomes of acute kidney injury in critically ill adult patients admited to the intensive care unit (ICU).
- Trial name
- AKI-EPI2 (NCT07207031)
- Where
- Belgium
- Volunteers
- 10,642 people
- Sponsor
- University Hospital, Ghent
Burns
Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients
Proline is a non-essential amino acid that helps with collagen formation. Collagen is one of the main ingredients of skin, bone, tendons, and connective tissue.
- Trial name
- NCT00217035
- Testing
- TPN or TPN enriched with glutamine
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Deglutition Disorders
Intensive Faciltiation of Swallowing in Patients With Severe Dysphagia After Acquired Brain Injury
This study is a randomized controlled trial (RCT). Patients after severe acquired brain injury (ABI) were randomised in addition to the individual daily rehabilitation program to intensive Facial Oral Tract Therapy (F.O.T.T.®)…
- Trial name
- NCT03145740
- Testing
- Intensive F.O.T.T.®, Unspecific Stimulation of face and mouth
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Trauma Patients
Effect of Severe Trauma on PD1 and Its Legend (PD1/L1) on T Lymphocytes and Correlation With Mortality
Unlike neuro-endocrine response to trauma; posttraumatic immune alterations are not easily carried out at bedside. The majority of trials were conducted in the intensive care usually hours to days post injury.
- Trial name
- NCT04233723
- Testing
- peripheral blood samples
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Severe Trauma Brain Injury, Intracranial Hypertension
Sodium-Lactate and Traumatic Brain Injury
The purpose of this study is to compare the effect of bolus of either sodium-lactate or mannitol on the evolution of intracranial pressure (ICP) during intracranial hypertensive episodes (IHE)
- Trial name
- NCT00319345
- Testing
- Mannitol, Sodium-Lactate
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
Brain Injuries, Traumatic
Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan
The purpose of this trial is to determine if mild hypothermia therapy, for severe head trauma patients, improves neurological outcome.
- Trial name
- NCT00134472
- Testing
- Therapeutic mild hypothermia
- Where
- 43 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Yamaguchi University Hospital
Brain Trauma
Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury
The present trial intends to assess whether Salovum®, an egg powder enriched for antisecretory factor given to patients with severe traumatic brain injury will improve outcome compared to a control group given placebo egg powder.
- Trial name
- SASAT (NCT03339505)
- Testing
- Salovum
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- Peter Siesjö
Severe Head Injury
Early Tracheostomy Versus Standard of Care in Patients With Severe Head Injury
Severe head injury is associated with airway compromise and poor respiratory effort. In Mulago Hospital intubation is the mainstay intervention and then patients are subjected to the wait and see strategy of delayed or no…
- Trial name
- E-Trac (NCT02442154)
- Testing
- Tracheostomy
- Where
- Uganda
- Volunteers
- 160 people
- Sponsor
- Makerere University