Clinical trials: Severe Trauma Patients
Neurocritical Care, Traumatic Brain Injury
Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care
Enhanced recovery after surgery (ERAS) is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a…
- Conditions
- Neurocritical Care, Traumatic Brain Injury, Cerebrovascular Disease, Moderate or Severe Coma
- Trial name
- NCT06241482
- Testing
- Enhanced recovery after surgery, Conventional therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai 6th People's Hospital
Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications
Prediction Model for MINS After Major Hepatobiliary Surgery
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications, Liver Neoplasm, Hepatobiliary Diseases
- Trial name
- NCT07335042
- Testing
- Major Hepatobiliary Surgery
- Where
- 6 sites in China
- Volunteers
- 1,800 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Traumatic Brain Injury
Safety of Darbepoetin Alfa Treatment in Patients With Severe Traumatic Brain Injury
The purpose of this study is to see if the treatment of severely brain injured patients with darbepoetin (a long acting form of erythropoietin) will be safe, and will reduce brain damage by decreasing harmful levels of chemicals…
- Trial name
- NCT00375869
- Testing
- Darbeopoetin
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Royal Alexandra Hospital
Ventilator-associated Pneumonia, Traumatic Brain Injury
Closed Versus Open Endotracheal Suctioning and Ventilator-Associated Pneumonia in Severe Traumatic Brain Injury
This randomized controlled trial will compare closed versus open endotracheal suctioning techniques for preventing ventilator-associated pneumonia (VAP) in adults with severe traumatic brain injury (TBI) who need mechanical…
- Trial name
- NCT07883083
- Testing
- Closed endotracheal suction system, Open endotracheal suction
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Minia University
Brain Trauma
Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury
The present trial intends to assess whether Salovum®, an egg powder enriched for antisecretory factor given to patients with severe traumatic brain injury will improve outcome compared to a control group given placebo egg powder.
- Trial name
- SASAT (NCT03339505)
- Testing
- Salovum
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- Peter Siesjö
Patients Who Are Victims of Major Trauma
In-Hospital Electronic Registry of Severe Trauma of the Fondazione I.R.C.C.S. Policlinico San Matteo
The objective of establishing an in-hospital Trauma Registry, aimed at collecting data on patients who are victims of major trauma and treated at our Center, is to develop a comprehensive and in-depth tool for the analysis and…
- Trial name
- STRAP register (NCT06930820)
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Chronic Kidney Disease, CKD
ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE
The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who…
- Conditions
- Chronic Kidney Disease, CKD, Cardiac Disease, Cardiopulmonary Bypass
- Trial name
- ARTEMIS (NCT05746559)
- Testing
- Ravulizumab
- Where
- 130 sites in United States, Argentina and 18 more
- Volunteers
- 555 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Sciatic Nerve Injury
Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury.
The primary purpose of this research study is to determine the safety of injecting ones own Schwann cells to augment sural nerve autografts after a severe, non-lacerating injury to the sciatic nerve has occurred.
- Trial name
- NCT02510079
- Testing
- Autologous human Schwann cells
- Where
- United States
- Sponsor
- W. Dalton Dietrich
Traumatic Head Injury
Retrospective Analysis of a Population of Patients With With Severe Traumatic Head Injury and Woken Early
Observational retrospective study that included all patients meeting the inclusion criteria from 1st January 2014 to 31st December 2015.
- Trial name
- PRECOCE TC (NCT03293420)
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Subacromial Impingement Syndrome
Comparison of Two Stretching Techniques in Patients Suffering From Subacromial Syndrome
The shoulder stability has always been related to the rotator cuff complex, although more and more is contemplated the Teres Major muscle and its affectation in the shape of the trigger points within this pathology.
- Trial name
- NCT04073199
- Testing
- Long Lever Group, Short Lever Group
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Trauma
Beta Blockade in Critical Injury
Critically injured patients endure a period of hypermetabolism/catabolism after being resuscitated. The metabolic cost of this may be measured in loss of lean body mass, poor wound healing, susceptibility to infection and long…
- Trial name
- NCT00356187
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Denver Health and Hospital Authority
Chronic Kidney Diseases, Acute Kidney Injury
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
The BRACKETS pilot study is a multicentre, prospective, randomized controlled trial of prophylactic preoperative tranexamic acid (TXA) versus placebo and, using a partial factorial design, of prophylactic preoperative…
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Bleeding, Surgery
- Trial name
- BRACKETS (NCT06337838)
- Testing
- Desmopressin Injectable Solution, Tranexamic Acid Injectable Product
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Peripheral Arterial Disease, Myocardial Injury
Cardiovascular Risk in Peripheral Artery Disease Patients Undergoing Endovascular Revascularisation
This study will investigate heart-related complications in patients with peripheral arterial disease (PAD) undergoing endovascular revascularization procedures to improve blood flow in the legs.
- Conditions
- Peripheral Arterial Disease, Myocardial Injury, Troponin, NT-proBNP
- Trial name
- RISK (NCT07599540)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Trauma
MaTOMS: A Feasibility Study Into Collecting Major Trauma Outcomes
Major Trauma Outcome Measures Study (MaTOMS): A feasibility Study into using outcome measures in major trauma patients. At present patients who suffer major trauma (multiple, serious injuries that could result in death or serious…
- Trial name
- MaTOMS (NCT03277560)
- Testing
- No Intervention as it is an observational study
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Oxford University Hospitals NHS Trust
Brain Concussion, Cerebral Concussion
Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for the Emergency Department (ED)…
- Conditions
- Brain Concussion, Cerebral Concussion, Concussion, Intermediate, Concussion, Mild
- Trial name
- DETECT (NCT02776462)
- Testing
- EyeBox CNS
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Oculogica, Inc.
Major Depressive Disorder, Early Life Trauma
Noradrenergic Activity, Cognition and Major Depressive Disorder
This study investigates influences of nordadrenergic activity on cognition in patients with major depression regarding influences of early life stress.
- Trial name
- YohCog (NCT02470026)
- Testing
- yohimbine
- Where
- Germany
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Patient Reported Outcome Measures, Recovery of Function
FIT Study (Functional Outcomes In Trauma Study)
Why? There is not much information in the UK on how well patients who sustain major trauma function afterwards. Major trauma is defined as significant injuries with a calculated 'injury severity score' (ISS) over 15.
- Conditions
- Patient Reported Outcome Measures, Recovery of Function, Rehabilitation, Disability Evaluation
- Trial name
- NCT04074382
- Testing
- Online Questionnaires, Qualitative Interviews
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
DVT
Bedside Ultrasound by Anesthesiologists for Screening Deep Venous Thrombosis
The study is designed as a prospective comparative study. All patients will receive prophylactic anticoagulation according to routine hospital protocol after surgery.
- Trial name
- NCT03443310
- Testing
- Ultrasound assessment of DVT
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Coma, Emotional Distress
The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries
The purpose of this study is to pilot a psychosocial skills-based intervention for caregivers of patients with severe acute brain injuries.
- Trial name
- COMA-F (NCT05761925)
- Testing
- COMA-F
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Consciousness Disorder, Brain Injuries
Neurovascular Reactions to AAT in Patients With DOC
There is practical evidence but no scientific investigations that persons with severe disorders of consciousness can profit from animal-assisted therapy regarding their level of awareness.
- Trial name
- AAT NIRS (NCT03341325)
- Testing
- animal-assisted activity, control activity
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute