Clinical trials: Severe Trauma Patients
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Brain Injury, Tracheostomy
Efficacy of an Early Rehabilitation on Decannulation Time of Patients With Severe Acquired Brain Injury
All the patients hospitalized in the neuro-rehabilitation after a severe acquired brain injury carrying a tracheal cannula will be retrospectively analyzed.
- Conditions
- Brain Injury, Tracheostomy, Neurological Rehabilitation
- Trial name
- NCT02990871
- Testing
- early neurological rehabilitation, no-early neurological rehabilitation
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Burns
Assessment of Mechanisms of Improved Wound Healing
The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.
- Trial name
- NCT00673309
- Testing
- Stable Isotope Infusion study, Insulin High Dose, oxandrolone
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Wounds and Injuries
Assessment of the Benefit of an Inclusive Health Organization on the Prognosis of Severe Trauma Patients
Appropriate management reduces the mortality of severe trauma victims. This is based on a pre-hospital medical assessment of severity, the initiation of life-saving treatments at the pre-hospital level, and referral to a hospital…
- Trial name
- TRAUMINXCLUSIF (NCT04275791)
- Testing
- Triage
- Where
- France
- Volunteers
- 2,193 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tendinopathy
Study of Efficacy and Safety of AIN457/Secukinumab in Patients With Rotator Cuff Tendinopathy
The purpose of this study was to investigate the efficacy and safety of secukinumab subcutaneously (s.c.) compared to placebo in adult patients with moderate to severe rotator cuff tendinopathy and failure to conventional therapy.
- Trial name
- UnchAIN (NCT05569174)
- Testing
- Secukinumab
- Where
- 19 sites in Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Acute Kidney Failure
Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT
The aim of this study is to measure plasma levels of essential vitamins, trace elements and amino acids in critically ill patients with severe AKI.
- Trial name
- NCT02470520
- Testing
- CRRT
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Severe Burn, Enternal Nutrition
A Study on Nutrition Support in Adult Patients With Severe Burns
To delineate nutritional support in adults patients with severe burns to investigate associations between nutritional practice and clinical outcomes.
- Trial name
- NCT03379116
- Testing
- enteral nutrition and parenteral nutrition
- Volunteers
- 100 people
- Sponsor
- Southeast University, China
Blood Pressure, Dexmedetomidine
Intraoperative Goal-directed Blood Pressure and Dexmedetomidine on Outcomes
Perioperative organ injuriy remain an important threat to patients undergoing major surgeries. Intraoperative hypotension is associated with an increase in postoperative morbidity and mortality.
- Conditions
- Blood Pressure, Dexmedetomidine, High-risk Patients, Abdominal Surgery
- Trial name
- NCT03933306
- Testing
- Dexmedetomidine, Goal-directed blood pressure management, Routine blood pressure management
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Peking University First Hospital
Chronic Pain, Limb Fracture
Chronic Pain Predictors in Major Trauma
The goal of this observational study is to learn about who is at risk of developing chronic pain in a major trauma population with at least one limb fracture.
- Trial name
- COPE: MT (NCT07237152)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- University of Nottingham
Sepsis, Delirium
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Ventilated ICU patients frequently have sepsis and the majority have delirium, a form of brain dysfunction that is an independent predictor of increased risk of dying, length of stay, costs, and prolonged cognitive impairment in…
- Conditions
- Sepsis, Delirium, Impaired Cognition
- Trial name
- MENDS2 (NCT01739933)
- Testing
- Dexmedetomidine, Propofol
- Where
- 11 sites in United States
- Volunteers
- 438 people
- Sponsor
- Vanderbilt University Medical Center
Corneal Epithelial Disorders
Safety and Efficacy of SJP-0035 Ophthalmic Solution in Patients With Moderate to Severe Corneal Epithelial Disorders
The purpose of this study is to determine whether SJP-0035 ophthalmic solution is effective in promoting corneal epithelial wound healing in conditions associated with corneal epithelial disorders.
- Trial name
- NCT02929823
- Testing
- High Dose SJP-0035 Ophthalmic Solution, Low Dose SJP-0035 Ophthalmic Solution, Vehicle of SJP-0035 Ophthalmic solution
- Where
- 19 sites in United States
- Volunteers
- 130 people
- Sponsor
- Senju Pharmaceutical Co., Ltd.
Surgical Site Infection, Bleeding
Mild Hypothermia Influence on Patient Outcome in Major Abdominal Surgery
This study investigate associations between mild hypothermia (patients' core temperature ≤ 36.0 degrees Celsius) and intra-operative blood loss and surgical site infections (SSI) in patients undergoing major abdominal surgery.
- Trial name
- NCT03112317
- Testing
- Prevention of hypothermia
- Where
- 2 sites in Norway
- Volunteers
- 3,059 people
- Sponsor
- Haukeland University Hospital
Burn, War-Related Injuries
ASV and Targeted Fluid Resuscitation in Severe Burns
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive…
- Conditions
- Burn, War-Related Injuries, Mechanical Ventilation, Infusion Fluid
- Trial name
- BURN-ASV/TFR (NCT07689097)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Severe Trauma
Author-Wang Ping-- Research：Application of Ultrasonic Guided Puncture in Blood Collection in Patients With Severe Trauma
This study aimed to investigate the application of ultrasound guided puncture technique in blood collection in patients with severe trauma.
- Trial name
- NCT04938674
- Testing
- ultrasonic guidance
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Major Depressive Disorder, Bipolar Disorder
Chart Review of Patients Undergoing Ketamine Infusions
The Canadian Rapid Treatment Center of Excellence (CRTCE) is a healthcare facility principally focused on providing best practices of intravenous ketamine treatment to adult patients suffering from mental health conditions.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Obsessive-Compulsive Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT04209296
- Testing
- Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 891 people
- Sponsor
- Brain and Cognition Discovery Foundation
Severe Traumatic Brain Injury With High Cerebral Pressure
Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury
Severe traumatic brain injury with increased intracranial pressure can lead to decreased cerebral blood flow. Low cerebral blood flow is responsible for secondary lesions, leading to bad prognosis.
- Trial name
- DEBITC (NCT02019810)
- Testing
- Norepinephrine, Dobutamine and norepinephrine
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Trauma
Evaluation of the Effectiveness of a Regional Trauma Care System for the Treatment of Patients With Severe Trauma
Severe trauma imposes a heavy burden to society and family because of its high mortality and disability rate. Based on the implementation plan of "one region", "two links", and "three teams", the Trauma Medicine Center of Peking…
- Trial name
- NCT05799170
- Testing
- regional trauma care
- Volunteers
- 3,200 people
- Sponsor
- Peking University People's Hospital
Cirrhosis, Liver, Bacterial Infections
Bacterial Infections in Cirrhotic Patients With Acute Severe Liver Injury
Acute hepatic insults including hepatitis flare-up, active alcohol assumption and hepatotoxic drug use are common in patients with cirrhosis especially in Eastern countries.These patients are at high risk of developing…
- Conditions
- Cirrhosis, Liver, Bacterial Infections, Acute Liver Injury
- Trial name
- NCT03204591
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Zhejiang Study Group for Organ Failure in Cirrhosis
Trauma
Metabonomics Fingerprinting of Multiple Trauma
The aim of this study is to establish plasma metabonomics fingerprinting atlas for severe multiple trauma patient using 1H nuclear magnetic resonance (NMR) based metabonomics methodology and advanced mathematics tools.
- Trial name
- NCT01279239
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences