Clinical trials: Severe Trauma Patients
Postoperative Acute Kidney Injury, Postoperative Complications
Hypotension Prediction Index-guided Hemodynamic Optimization Trial to Reduce Postoperative Acute Kidney Injury (HYT).
MAIN AIM OF THE STUDY To establish whether hemodynamic management guided by the hypotension prediction index (HPI) guided by the administration of intravenous fluids and vasoactive drugs in patients undergoing elective major…
- Trial name
- HYT (NCT05569265)
- Testing
- Intraoperative hemodynamic management
- Where
- 26 sites in Spain
- Volunteers
- 958 people
- Sponsor
- Maria José Clara Colomina Soler
Cardiovascular Diseases, Cardiovascular Complication
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery.
- Conditions
- Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury
- Trial name
- COLCAT (NCT06279000)
- Testing
- Colchicine
- Where
- Switzerland
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Burns, Trauma
Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers.
- Trial name
- NCT01812941
- Testing
- trauma: blood collection, healthy volunteers: blood collection, Burn: blood collection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Coagulopathy, Trauma
Effect of Hypocalcemia on the Outcome of Elderly Major Trauma Patients With Trauma-induced Coagulopathy
Hypocalcaemia is an independent risk factor of TIC in elderly trauma patients. TIC combined with hypocalcemia had worse coagulation function and more serious acidosis.
- Trial name
- NCT05530161
- Testing
- hypocalcemia
- Where
- China
- Volunteers
- 371 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
AKI - Acute Kidney Injury, PAI-1 4G/5G Polymorphism
Correlation Study of PAI-1 4G/5G Polymorphism and Postoperative AKI in Patients With Aortic Dissection
To explore the association between PAI-1 4G5G polymorphism and the risk of CSA-AKI in Stanford type A dissection patients undergoing open-heart repair surgery.
- Conditions
- AKI - Acute Kidney Injury, PAI-1 4G/5G Polymorphism, Aortic Dissection
- Trial name
- NCT05490394
- Where
- China
- Volunteers
- 283 people
- Sponsor
- Xijing Hospital
Traumatic Brain Injury
Multiomic Analysis of Serum in Acute Period of Traumatic Brain Injury
The goal of this experimental observation study is to figure out differently expressed biomarkers in serum in traumatic brain injury patients, compared with bone fracture patients. The main questions it aims to answer are: 1.
- Trial name
- MASTER-TBI (NCT05867992)
- Testing
- Type of trauma
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Patients With Major Burn Injury in Formosa FunCost Explosion
Outcome Evaluation for Burn Scar Therapy-laser and Surgery in Patients in Formosa Fun Coast Explosion
Protocol title： Outcome evaluation for burn scar therapy-laser and surgery in patients in Formosa Fun Coast Explosion Objectives： The goal of this study is to evaluate the effectiveness of both lasers and operations on patients…
- Trial name
- NCT03922399
- Testing
- Laser and Surgery
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Acute Pain
A Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of IV Acetaminophen for the Treatment of Acute Pain in Pediatric Patients
The purpose of this study is to demonstrate the efficacy and safety of Intravenous (IV) acetaminophen plus rescue opioids for the relief of moderate to severe acute pain in neonates and infants (age < 2 years) compared to placebo…
- Trial name
- NCT01635101
- Testing
- IV Acetaminophen, IV Control
- Where
- 22 sites in United States
- Volunteers
- 197 people
- Sponsor
- Mallinckrodt
Brain Injury Traumatic Severe, Subarachnoid Hemorrhage
Mobilising Patients With Severe Brain Injury in Intensive Care
Introduction Patients with severe brain injury are often restricted to bed rest during the early period of brain injury which may lead to unwanted secondary complications.
- Conditions
- Brain Injury Traumatic Severe, Subarachnoid Hemorrhage, Intracranial Hematoma
- Trial name
- MAWERIC (NCT05038930)
- Testing
- Mobilisation using the Sara Combilizer
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fractures, Comminuted, Fracture Fixation, Internal
Comparative Study of Fixation or Fusion of Calcaneal Fractures
A multicentre randomized controlled trial that will be conducted at Level 1 trauma centres across Canada. It will compare patients who receive open reduction, internal fixation for Sanders IV calcaneal fractures to patients who…
- Trial name
- Sanders IV (NCT00679393)
- Testing
- Open reduction internal fixation, Fusion
- Where
- 4 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Head Trauma
Monitoring of Intracranial Hemorrhage in Non-severe Head Trauma Patients Hospitalized in the UHCD
The non-neurosurgical management of post-traumatic cerebral hemorrhagic lesions is currently poorly codified. It consists of neurological monitoring for 24 to 48 hours, and the performance of an almost systematic brain scan.
- Trial name
- Head-Trauma (NCT06173427)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Strasbourg, France
Burn Injury, Physical Injury
STAT: Standard Therapy Plus Active Therapy
The objective of the study is to assess the efficacy of STAT, an activity-based therapy protocol compared to standard therapy (ST) to improve functional outcome and reduce disability in patients recovering from burn injury.
- Conditions
- Burn Injury, Physical Injury, Thermal Burn
- Trial name
- STAT (NCT04368117)
- Testing
- Physical Therapy
- Where
- 7 sites in United States
- Volunteers
- 166 people
- Sponsor
- American Burn Association
Chronic Liver Disease
Efficacy and Safety of Plasma Exchange Compared to Standard Medical Therapy in Patients With Severe Drug Induced Liver Injury With or Without Underlying Chronic Liver Disease.
In this randomized study subject will be randomized into two groups Group A will receive Standard Medical Treatment (Albumin + High Caloric Diet) Group B will continue Standard Medical Treatment with High Volume Plasma Exchange.
- Trial name
- NCT04015570
- Testing
- High Volume Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Trauma Injury
Retrospective Assessment of Referral of a Major Trauma Patient
The aim of this study is to find out whether major trauma patients from the Val d'Oise are referred to the appropriate trauma centre for their care and to assess the quality of triage within the Val d'Oise department.
- Trial name
- SAMU-TRAUMAS (NCT06551350)
- Testing
- Data Collection
- Where
- France
- Volunteers
- 461 people
- Sponsor
- Hôpital NOVO
Trauma, Brain
PRECISION-TBI - An Observational Study of Patients With Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) is a devastating condition and a leading cause of long-term disability. Every patient with TBI has a different type of injury and is treated differently from hospital to hospital making it very…
- Trial name
- NCT05855252
- Testing
- No intervention
- Where
- 9 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Brain Injury Traumatic Diffuse With Loss of Consciousness
Clinical Analysis of Early Hormones Between Patients With Traumatic Brain Injury and Cerebral Hemorrhage
Our understanding of neurosecretory dysfunction after TBI is still insufficient, and the number of patients with neuroendocrine dysfunction caused by craniocerebral trauma may be underestimated, especially the neuroendocrine…
- Trial name
- NCT06221215
- Testing
- trauma
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
Trauma; Complications
Nephroprotection in Severe Trauma Patients With Kidney Stress
Acute Kidney Injury (AKI) occurs in 24% of trauma patients, and is even more common in those with severe trauma. It is a major contributor to morbidity and mortality in trauma.
- Trial name
- NephroTrauma (NCT06834633)
- Testing
- Standard-of-care, Systematic nephroprotection bundle-of-care
- Where
- 6 sites in France
- Volunteers
- 523 people
- Sponsor
- Hospices Civils de Lyon
Head Injury Trauma, Hyperventilation
Hyperventilation in Patients With Traumatic Brain Injury
Elevated intracranial pressure is a dangerous and potentially fatal complication after traumatic brain injury. Hyperventilation is a medical intervention to reduce elevated intracranial pressure by inducing cerebral…
- Trial name
- NCT03822026
- Testing
- Hyperventilation test
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Ventilation-associated Pneumonia, Severe Trauma Patient
Impact of the Addition of a Device Providing Continuous Pneumatic Regulation of Tube Cuff Pressure to an Overall Strategy Aimed at Preventing Ventilator-associated Pneumonia in the Severe Trauma Patient. A Multicentre, Randomised, Controlled Study.
Ventilation-associated pneumonia is the main site of healthcare-associated infections in the severe trauma patient, with a mean incidence rate of 35%.
- Trial name
- AGATE (NCT02534974)
- Testing
- NOSTEN
- Where
- 13 sites in France
- Volunteers
- 440 people
- Sponsor
- Poitiers University Hospital