Clinical trials: Sex Differences, active
Exercise, BDNF
Sex Differences in BDNF Study
A single bout of exercise can improve cognitive abilities like memory and attention. These functions help us navigate through everyday life. However, we do not fully understand how exercise improves cognitive abilities.
- Conditions
- Exercise, BDNF, Sex Differences
- Trial name
- BDNF-SD (NCT07912307)
- Testing
- VO2peak Test
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Turner Syndrome, Post-menarcheal Adolescents
Gonadal Tissue Freezing for Fertility Preservation in Individuals at Risk for Ovarian Dysfunction, Premature Ovarian Insufficiency and Clinically Indicated Gonadectomy
Background: Turner Syndrome, galactosemia, and premature ovarian insufficiency are all conditions that may make it very hard or impossible for a person to become pregnant and have their own child.
- Conditions
- Turner Syndrome, Post-menarcheal Adolescents, Ovarian Disfunction, Galactosemia
- Trial name
- NCT04948658
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Stress, Early Life Stress
How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play?
The study aims to investigate sex differences in the effect of mu-opioid receptor (MOR) activation on stress response and social behaviour modulated by early life stress.
- Conditions
- Stress, Early Life Stress, Sex Differences, Opioid
- Trial name
- MOR-SAFE (NCT07778511)
- Testing
- Morphine
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sara L. Kroll
Fasting, Obesity (BMI>30)
The Effect of Fasting on Peak Fat Oxidation, Mitochondrial Coupling and Extracellular Matrix
The interventional study will recruit four groups (n=10 per group): Young men and women with normal weight (BMI 18-25), and young men and women with obesity (BMI >30).
- Conditions
- Fasting, Obesity (BMI>30), Sex Difference
- Trial name
- GlycoFast84 (NCT07692646)
- Testing
- Diet
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Postoperative Delirium (POD), Sex Differences
Sex-Dependent Risk of Postoperative Delirium and Mediating Effects of Family Visits
Postoperative delirium is a common and serious complication after surgery, affecting 10-40% of older patients undergoing non-cardiac procedures.
- Trial name
- NCT07502391
- Where
- Switzerland
- Volunteers
- 471 people
- Sponsor
- Julian Rössler
Sex Difference, Virtual Care
VR Learning Program for Sexual-and-gender-diversity Care
The study is designed to create a VR learning program for sexual-and-gender-diversity care and compare the short-term and long-term effects on caring behaviors in nursing students.
- Conditions
- Sex Difference, Virtual Care, Nursing Care
- Trial name
- NCT07535216
- Testing
- VR learning program for SGD care
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Red Blood Cell Transfusions, Sex Differences
Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes
Red blood cell (RBC) transfusions are selected based upon matching donor and recipient blood group: donor and recipient sex are not considered when selecting blood for transfusion.
- Conditions
- Red Blood Cell Transfusions, Sex Differences, Health Services, Critically Ill Intensive Care Unit Patients
- Trial name
- SexMATTERS RCT (NCT06840756)
- Testing
- Sex-mismatched red blood cell transfusions, Sex-matched red blood cell transfusions
- Where
- 8 sites in Canada
- Volunteers
- 11,082 people
- Sponsor
- Michelle Zeller
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Meningococcal Meningitis, Serogroup B, Transgender Persons
Investigating Gender and Sex Differences in Immune Responses Through Vaccination of Transgender and Cisgender Persons
Sexual differences are a well-established source of biological variation in immune system functioning, with men often displaying lower adaptive immune responses (e.g.
- Conditions
- Meningococcal Meningitis, Serogroup B, Transgender Persons, Sex Differences in Immune Response, Vaccination
- Trial name
- Vaxxygender (NCT06832514)
- Testing
- Serogroup B meningococal vaccine
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Ghent
Sleep Deprivation, Sex Differences
Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment
The goal of this study is to learn whether insufficient sleep affects glucose metabolism differently in healthy men and women.
- Conditions
- Sleep Deprivation, Sex Differences, Glucose Tolerance
- Trial name
- NCT06809023
- Testing
- Sleep restriction
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cognitive Assessment, Cognition
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults.
- Conditions
- Cognitive Assessment, Cognition, taVNS, Vagus Nerve Stimulation
- Trial name
- NCT07256080
- Testing
- Active taVNS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Inactivity, Physical, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum
The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Growth & Development
- Trial name
- NFRF (NCT06744491)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Myocardial Infarction, Sex Differences
Hs-cTn - Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women
The project is focussed on evaluating the impact of using a female-specific threshold in the diagnosis of myocardial infarction. This female threshold is lower than the overall hs-cTn threshold currently in use.
- Conditions
- Myocardial Infarction, Sex Differences, High Sensitivity Troponin
- Trial name
- CODE-MI (NCT03819894)
- Testing
- Introduction of a lower female hs-cTn threshold
- Where
- Canada
- Volunteers
- 24,000 people
- Sponsor
- BC Centre for Improved Cardiovascular Health
Thrombosis, Exercise Training
The Effect of Team Sports on the Risk of Thrombosis in Elderly Individuals in a Municipality Setting (TEAM-AGE)
Cardiovascular disease, and especially myocardial infarction, is the most common cause of death globally, and is particularly common in older individuals.
- Conditions
- Thrombosis, Exercise Training, Sex Differences
- Trial name
- TEAM-AGE (NCT04611191)
- Testing
- Team Sports, Control
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen