Clinical trials: Sexual Transmission of Infection
Cervical Cancers, Vulvar Cancers
A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASIL™ (V503-006)
This study will evaluate whether V503 (9vHPV vaccine), is well tolerated in girls and women between 12 and 26 years old who have previously been vaccinated with GARDASIL™.
- Conditions
- Cervical Cancers, Vulvar Cancers, Vaginal Cancers, Genital Warts
- Trial name
- NCT01047345
- Testing
- V503
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Darunavir/Ritonavir and Rosuvastatin Pharmacokinetic Study
This is a phase I, open-label, controlled drug interaction study to determine the effects of darunavir plus ritonavir on the pharmacokinetics of the hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, rosuvastatin, in…
- Trial name
- NCT00885495
- Testing
- darunavir, ritonavir, rosuvastatin, rosuvastatin, darunavir, ritonavir
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Cryptococcal Meningitis, HIV Infections
AmB Dose for Cryptococcal Meningitis
Cryptococcal meningitis (CM) is one of the leading opportunistic infections and one of the most common causes of death in AIDS patients. Amphotericin B (AmB) is the corner stone in CM treatment.
- Trial name
- NCT04140461
- Testing
- Amphotericin B, Flucytosine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Public Health Clinical Center
HIV Infections
Prospective Non-Interventional Observational Study of Use of TRIUMEQ and Corresponding Monitoring Measures in Clinical Practice in Germany
TRIUMPH is a prospective, non-interventional observational study on the use of the fixdose combination TRIUMEQ (Dolutegravir/Abacavir/Lamivudine) and the respective monitoring measures in the practice of HIV care in Germany.
- Trial name
- TRIUMPH (NCT02342769)
- Testing
- Dolutegravir/Abacavir/Lamivudin
- Where
- 29 sites in Germany
- Volunteers
- 403 people
- Sponsor
- ViiV Healthcare
HIV Infection
Cellulose Sulfate and HIV Transmission Among Women
The purpose of the study is to determine the effect of cellulose sulfate on the transmission of HIV to women via vaginal intercourse.
- Trial name
- NCT00153777
- Testing
- Cellulose Sulfate gel (6%)
- Where
- 5 sites in Benin, India and 2 more
- Volunteers
- 1,428 people, healthy volunteers welcome
- Sponsor
- CONRAD
Sexually Transmitted Diseases, Bacterial, Syphilis
Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
The goal of this clinical trial is to compare the effectiveness of doxycycline taken for on-demand pre-exposure prophylaxis (DoxyODPrEP) and its post-exposure use (DoxyPEP) in preventing bacterial sexually transmitted infections…
- Conditions
- Sexually Transmitted Diseases, Bacterial, Syphilis, Gonorrhea, Chlamydia
- Trial name
- NCT06188442
- Testing
- DoxyODPrEP, DoxyPEP
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HIV Infections
PK of Once Daily ART Containing Tenofovir and Atazanavir/Ritonavir
The purpose of this project is to study the pharmacokinetics of a once-daily antiretroviral medication used to treat adolescents and young adults with HIV infection.
- Trial name
- NCT00273273
- Testing
- blood draw
- Where
- 12 sites in United States, Puerto Rico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Early Syphilis, Latent, Serological Relapse After Treatment
Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline
This randomized controlled superiority study will be conducted during 2023-2025. The eligible participants are adult people living with HIV (PLWH) who are newly diagnosed with early syphilis.
- Trial name
- NCT06069141
- Testing
- Benzathine Penicillin G, Doxycycline Capsule
- Where
- 9 sites in Taiwan
- Volunteers
- 688 people
- Sponsor
- National Taiwan University Hospital
HIV Infections
Fuzeon (Enfuvirtide) Early Access Program for Patients With HIV-1 Infection
This study will determine the safety and tolerability of Fuzeon (enfuvirtide) used together with other treatments for HIV infection in patients with advanced HIV disease. Fuzeon is an antiretroviral drug.
- Trial name
- NCT00050856
- Testing
- Enfuvirtide T/20/Ro 29,9800, HIV-1 Infusion Inhibitor
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Evaluating the Pharmacokinetics of 400 mg Oral Dose of Raltegravir in HIV-Infected Pre-Menopausal Women
The purpose of this study is to characterize the pharmacokinetics of raltegravir in cervicovaginal fluids as compared to blood plasma of HIV-infected pre-menopausal women.
- Trial name
- NCT00961272
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kristine Patterson, MD
HIV Infections
Blood Levels of Abacavir After One Dose in HIV-Infected Children and Adolescents
The purpose of this study is to measure blood levels of abacavir in children and adolescents over a period of time following a single dose so that a dosage for adolescents can be determined.
- Trial name
- NCT00011479
- Testing
- Abacavir sulfate
- Where
- 24 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Tenofovir DF (Disoproxil Fumarate) in Combination With Emtricitabine in HIV-1 Patients
The purpose of this study is to provide long-term clinical safety and efficacy data for tenofovir disoproxil fumarate and emtricitabine in HIV-infected patients experiencing various degrees of renal impairment.
- Trial name
- NCT00106379
- Testing
- Truvada (tenofovir DF + emtricitabine), Emtriva (emtricitabine), Viread (tenofovir DF)
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Gilead Sciences
HPV Infection
Polyhexamethylene Biguanide Increases the Regression Rate of Human Papillomavirus (HPV) Infection
Human papillomavirus (HPV) infection is a worldwide problem strictly linked to the development of cervical cancer. Persistence of the infection is one of the main factors responsible for the invasive progression and women…
- Trial name
- NCT01571141
- Testing
- Monogin
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
HIV Infections
Atazanavir or Lopinavir in HIV Post-exposure Prophylaxis
The study compares the adherence of 240 HIV-negative subjects randomly assigned to 2 different antiretroviral therapies for 28 days after accidental exposure to HIV.
- Trial name
- NCT00385645
- Testing
- Combivir+Kaletra, Combivir+Reyataz
- Where
- 7 sites in Spain
- Volunteers
- 255 people
- Sponsor
- Hospital Clinic of Barcelona
HIV Infections, Peripheral Nervous System Disease
A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy
To assess the efficacy, safety, and tolerability of recombinant human nerve growth factor ( rhNGF ) in the treatment of HIV-associated sensory neuropathy.
- Trial name
- NCT00000842
- Testing
- Nerve Growth Factor, Recombinant Human
- Where
- 14 sites in United States
- Volunteers
- 270 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus (HIV)
An Italian Observation of Antiretroviral Treatment in Participants Taking Darunavir/ Cobicistat Plus Emtricitabine and Tenofovir Alafenamide Fumarate
The purpose of this study is to describe the effectiveness of Darunavir/ Cobicistat/ Emtricitabine/ Tenofovir Alafenamide (D/C/F/TAF), measured as virological response at Week 48 as per Food and Drug Administration (FDA) snapshot…
- Trial name
- DIAMANTE (NCT03577470)
- Testing
- D/C/F/TAF Fixed-Dose Combination (FDC)
- Where
- 18 sites in Italy
- Volunteers
- 246 people
- Sponsor
- Janssen-Cilag S.p.A.
HIV Infections
Evaluating the Safety and Priming Response of an HIV Vaccine Regimen in Healthy, HIV-Uninfected Adults
This study will evaluate the safety of and the body's immune response to experimental HIV vaccine regimens using different vaccine priming combination, and boosting with the vaccines NYVAC and AIDSVAX® B/E.
- Trial name
- NCT01799954
- Testing
- DNA-HIV-PT123, NYVAC-HIV-PT1, NYVAC-HIV-PT4
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- HIV Vaccine Trials Network
Human Immunodeficiency Virus
Efficacy of BIC/F/TAF Versus Standard of Care in the Treatment of New HIV Infection Diagnoses in the Context of 'Test and Treat'
The administration of combination antiretroviral therapy (cART) to HIV-infected patients has been associated with a dramatic reduction in AIDS-related morbidity and mortality.
- Trial name
- BIC-T&T (NCT04653194)
- Testing
- Biktarvy, Symtuza
- Where
- 3 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
HIV Infections
The Effect of Anti-HIV Therapy on Fat Metabolism in HIV-Positive Patients
The purpose of this study is to see how taking certain anti-HIV drugs affects the way the body metabolizes fat. This study will evaluate patients who are enrolled in CPCRA 058 (the FIRST [Flexible Initial Retrovirus Suppressive…
- Trial name
- NCT00001102
- Where
- 15 sites in United States
- Volunteers
- 460 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Chronic Hepatitis B
Lamivudine and Adefovir to Treat Chronic Hepatitis B Infection in People With and Without HIV Infection
This study will evaluate the safety and effectiveness of adefovir plus lamivudine for chronic hepatitis B infection in people with and without HIV infection.
- Trial name
- NCT00023153
- Testing
- Adefovir Dipivoxil
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)